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Physical activity reduces the risk of dementia in mild cognitive impairment subjects: a cohort study.
J Alzheimers Dis. 2014; 39(4):833-9.JA

Abstract

BACKGROUND

Leisure activities, particularly exercise, play a protective role against dementia in healthy people, but it is unknown if this protective effect could be generalized to subjects with mild cognitive impairment (MCI).

OBJECTIVE

To investigate the influence of leisure activities on the risk of progression of MCI to dementia.

METHODS

176 MCI subjects attending a memory clinic underwent a standardized lifestyle questionnaire between October 2007 and May 2010. Social, cognitive, and physical scores were derived based on the assiduity of interpersonal contacts and on the frequency of participation in individual leisure activities. Subjects were requested to return every 12 months for dementia surveillance. The outcome measure was the risk of dementia associated with social, cognitive, and physical scores.

RESULTS

Over a median follow-up time of 2.59 year, 92 (52.2%) MCI subjects developed dementia. Subjects with physical scores in the highest third had a lower risk (HR 0.44; 95% CI 0.23-0.85) of dementia compared with those in the lowest third. No association was found between cognitive or social scores and the risk of dementia.

CONCLUSION

To our knowledge, this is the first prospective clinical study which demonstrates that high levels of participation in physical leisure activities are associated with reduced risk of dementia in subjects with MCI. In line with findings coming from community-based studies on healthy elderly, our finding suggests that the protective role of exercise against the development of dementia can be generalized to MCI subjects seen in clinical practice. Clinicians should encourage MCI subjects to participate in physical leisure activities.

Authors+Show Affiliations

Centre for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, "Luigi Sacco" Hospital, Milan, Italy Department of Biomedical and Clinical Sciences "Luigi Sacco" Hospital, University of Milan, Milan, Italy.National Centre for Epidemiology, Surveillance and Health Promotion, National Institute of Health, Rome, Italy.Centre for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, "Luigi Sacco" Hospital, Milan, Italy.Centre for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, "Luigi Sacco" Hospital, Milan, Italy.Centre for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, "Luigi Sacco" Hospital, Milan, Italy.Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.Centre for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, "Luigi Sacco" Hospital, Milan, Italy Department of Biomedical and Clinical Sciences "Luigi Sacco" Hospital, University of Milan, Milan, Italy.Centre for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, "Luigi Sacco" Hospital, Milan, Italy Department of Biomedical and Clinical Sciences "Luigi Sacco" Hospital, University of Milan, Milan, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24296815

Citation

Grande, Giulia, et al. "Physical Activity Reduces the Risk of Dementia in Mild Cognitive Impairment Subjects: a Cohort Study." Journal of Alzheimer's Disease : JAD, vol. 39, no. 4, 2014, pp. 833-9.
Grande G, Vanacore N, Maggiore L, et al. Physical activity reduces the risk of dementia in mild cognitive impairment subjects: a cohort study. J Alzheimers Dis. 2014;39(4):833-9.
Grande, G., Vanacore, N., Maggiore, L., Cucumo, V., Ghiretti, R., Galimberti, D., Scarpini, E., Mariani, C., & Clerici, F. (2014). Physical activity reduces the risk of dementia in mild cognitive impairment subjects: a cohort study. Journal of Alzheimer's Disease : JAD, 39(4), 833-9. https://doi.org/10.3233/JAD-131808
Grande G, et al. Physical Activity Reduces the Risk of Dementia in Mild Cognitive Impairment Subjects: a Cohort Study. J Alzheimers Dis. 2014;39(4):833-9. PubMed PMID: 24296815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity reduces the risk of dementia in mild cognitive impairment subjects: a cohort study. AU - Grande,Giulia, AU - Vanacore,Nicola, AU - Maggiore,Laura, AU - Cucumo,Valentina, AU - Ghiretti,Roberta, AU - Galimberti,Daniela, AU - Scarpini,Elio, AU - Mariani,Claudio, AU - Clerici,Francesca, PY - 2013/12/4/entrez PY - 2013/12/4/pubmed PY - 2014/10/31/medline KW - Dementia KW - exercise KW - leisure activities KW - lifestyle KW - mild cognitive impairment SP - 833 EP - 9 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 39 IS - 4 N2 - BACKGROUND: Leisure activities, particularly exercise, play a protective role against dementia in healthy people, but it is unknown if this protective effect could be generalized to subjects with mild cognitive impairment (MCI). OBJECTIVE: To investigate the influence of leisure activities on the risk of progression of MCI to dementia. METHODS: 176 MCI subjects attending a memory clinic underwent a standardized lifestyle questionnaire between October 2007 and May 2010. Social, cognitive, and physical scores were derived based on the assiduity of interpersonal contacts and on the frequency of participation in individual leisure activities. Subjects were requested to return every 12 months for dementia surveillance. The outcome measure was the risk of dementia associated with social, cognitive, and physical scores. RESULTS: Over a median follow-up time of 2.59 year, 92 (52.2%) MCI subjects developed dementia. Subjects with physical scores in the highest third had a lower risk (HR 0.44; 95% CI 0.23-0.85) of dementia compared with those in the lowest third. No association was found between cognitive or social scores and the risk of dementia. CONCLUSION: To our knowledge, this is the first prospective clinical study which demonstrates that high levels of participation in physical leisure activities are associated with reduced risk of dementia in subjects with MCI. In line with findings coming from community-based studies on healthy elderly, our finding suggests that the protective role of exercise against the development of dementia can be generalized to MCI subjects seen in clinical practice. Clinicians should encourage MCI subjects to participate in physical leisure activities. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/24296815/Physical_activity_reduces_the_risk_of_dementia_in_mild_cognitive_impairment_subjects:_a_cohort_study_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-131808 DB - PRIME DP - Unbound Medicine ER -