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Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-d-aspartate receptor encephalitis.
Eur Neurol. 2014; 71(1-2):42-8.EN

Abstract

BACKGROUND

The clinical importance of ovarian teratoma in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been established, however investigations of ovarian teratoma in patients with anti-NMDAR encephalitis remain limited.

OBJECTIVE

To clarify differences in NMDAR distribution and lymphocyte infiltration in ovarian teratoma between patients with and without anti-NMDAR encephalitis.

METHODS

Participants initially comprised 26 patients with ovarian teratomas. NMDAR distribution and lymphocyte infiltration in ovarian teratomas were examined using immunopathological techniques. Clinical, laboratory, and radiological data were compared between patients showing the features of encephalitis. Anti-NMDAR antibodies in the serum and cerebrospinal fluid were also measured in encephalitis patients.

RESULTS

Neuronal tissues were obtained from ovarian teratomas in 22 patients (after excluding 4 patients who did not satisfy the inclusion criteria), and the presence of NMDA receptor subunits was revealed in all patients. Lymphocyte infiltration was more frequent in the encephalitis group (n = 3) than in the non-encephalitis group. In particular, dense B-lymphocyte infiltration near neural tissues was observed in the encephalitis group.

CONCLUSIONS

Differences in lymphocyte infiltration in ovarian teratomas between anti-NMDAR encephalitis and non-encephalitis patients suggest the immunological importance of the ovarian teratoma as the site of antigen presentation in anti-NMDAR encephalitis.

Authors+Show Affiliations

Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24296881

Citation

Tabata, Emi, et al. "Immunopathological Significance of Ovarian Teratoma in Patients With anti-N-methyl-d-aspartate Receptor Encephalitis." European Neurology, vol. 71, no. 1-2, 2014, pp. 42-8.
Tabata E, Masuda M, Eriguchi M, et al. Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-d-aspartate receptor encephalitis. Eur Neurol. 2014;71(1-2):42-8.
Tabata, E., Masuda, M., Eriguchi, M., Yokoyama, M., Takahashi, Y., Tanaka, K., Yukitake, M., Horikawa, E., & Hara, H. (2014). Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-d-aspartate receptor encephalitis. European Neurology, 71(1-2), 42-8. https://doi.org/10.1159/000353982
Tabata E, et al. Immunopathological Significance of Ovarian Teratoma in Patients With anti-N-methyl-d-aspartate Receptor Encephalitis. Eur Neurol. 2014;71(1-2):42-8. PubMed PMID: 24296881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-d-aspartate receptor encephalitis. AU - Tabata,Emi, AU - Masuda,Masanori, AU - Eriguchi,Makoto, AU - Yokoyama,Masatoshi, AU - Takahashi,Yoshiyuki, AU - Tanaka,Keiko, AU - Yukitake,Motohiro, AU - Horikawa,Etsuo, AU - Hara,Hideo, Y1 - 2013/11/27/ PY - 2013/02/22/received PY - 2013/06/23/accepted PY - 2013/12/4/entrez PY - 2013/12/4/pubmed PY - 2014/10/24/medline SP - 42 EP - 8 JF - European neurology JO - Eur Neurol VL - 71 IS - 1-2 N2 - BACKGROUND: The clinical importance of ovarian teratoma in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been established, however investigations of ovarian teratoma in patients with anti-NMDAR encephalitis remain limited. OBJECTIVE: To clarify differences in NMDAR distribution and lymphocyte infiltration in ovarian teratoma between patients with and without anti-NMDAR encephalitis. METHODS: Participants initially comprised 26 patients with ovarian teratomas. NMDAR distribution and lymphocyte infiltration in ovarian teratomas were examined using immunopathological techniques. Clinical, laboratory, and radiological data were compared between patients showing the features of encephalitis. Anti-NMDAR antibodies in the serum and cerebrospinal fluid were also measured in encephalitis patients. RESULTS: Neuronal tissues were obtained from ovarian teratomas in 22 patients (after excluding 4 patients who did not satisfy the inclusion criteria), and the presence of NMDA receptor subunits was revealed in all patients. Lymphocyte infiltration was more frequent in the encephalitis group (n = 3) than in the non-encephalitis group. In particular, dense B-lymphocyte infiltration near neural tissues was observed in the encephalitis group. CONCLUSIONS: Differences in lymphocyte infiltration in ovarian teratomas between anti-NMDAR encephalitis and non-encephalitis patients suggest the immunological importance of the ovarian teratoma as the site of antigen presentation in anti-NMDAR encephalitis. SN - 1421-9913 UR - https://www.unboundmedicine.com/medline/citation/24296881/Immunopathological_significance_of_ovarian_teratoma_in_patients_with_anti_N_methyl_d_aspartate_receptor_encephalitis_ L2 - https://www.karger.com?DOI=10.1159/000353982 DB - PRIME DP - Unbound Medicine ER -