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Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis.
Carbohydr Polym. 2014 Jan 30; 101:313-23.CP

Abstract

The anti-HMPV (human metapneumovirus) activity was determined for sulfated dl-hybrid galactans obtained from the red seaweed Cryptonemia seminervis and their depolymerized products obtained by reductive partial hydrolysis. Structural studies carried out in three homogeneous depolymerized fractions DS-1, DS-2e and DS-3 (Mw of 51.6-63.8 kDa) showed that these galactans present different chemical characteristics, as monosaccharide composition, content of sulfate groups (14.1-29.9%) and agaran:carrageenan molar ratio diads, 2.7:1 for DS-1 and DS-2e and 1:1 for DS-3. The sulfate groups are located principally on C-2 of β-d-galactopyranose and 4,6-O-(1'-carboxyethylidene)-β-d-galactopyranose residues and on C-6 of α-galactose residues. Sulfated dl-galactans and their depolymerized products exhibited antiviral activity at a very early stage of the viral infection cycle. All fractions, except DS-2e inhibited HMPV replication by binding to the viral particle. Besides depolymerized galactans DS-2e and DS-3 inhibited the recognition of cell receptor by HMPV and penetration to the host cell, respectively.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mendes GS
Laboratório Experimental de Drogas Antivirais e Citotóxicas, Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Brazil; Laboratório de Viroses Respiratórias, Entéricas e Oculares, Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Brazil.
Duarte ME
No affiliation info available
Colodi FG
No affiliation info available
Noseda MD
No affiliation info available
Ferreira LG
No affiliation info available
Berté SD
No affiliation info available
Cavalcanti JF
No affiliation info available
Santos N
No affiliation info available
Romanos MT
No affiliation info available

MeSH

AnimalsAntiviral AgentsCell LineGalactansHumansMetapneumovirusPolymerizationRhodophytaSulfates

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24299779

Citation

Mendes, Gabriella S., et al. "Structure and Anti-metapneumovirus Activity of Sulfated Galactans From the Red Seaweed Cryptonemia Seminervis." Carbohydrate Polymers, vol. 101, 2014, pp. 313-23.
Mendes GS, Duarte ME, Colodi FG, et al. Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis. Carbohydr Polym. 2014;101:313-23.
Mendes, G. S., Duarte, M. E., Colodi, F. G., Noseda, M. D., Ferreira, L. G., Berté, S. D., Cavalcanti, J. F., Santos, N., & Romanos, M. T. (2014). Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis. Carbohydrate Polymers, 101, 313-23. https://doi.org/10.1016/j.carbpol.2013.09.026
Mendes GS, et al. Structure and Anti-metapneumovirus Activity of Sulfated Galactans From the Red Seaweed Cryptonemia Seminervis. Carbohydr Polym. 2014 Jan 30;101:313-23. PubMed PMID: 24299779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis. AU - Mendes,Gabriella S, AU - Duarte,Maria E R, AU - Colodi,Franciely G, AU - Noseda,Miguel D, AU - Ferreira,Luciana G, AU - Berté,Siliane D, AU - Cavalcanti,Jéssica F, AU - Santos,Norma, AU - Romanos,Maria T V, Y1 - 2013/09/14/ PY - 2013/06/30/received PY - 2013/08/24/revised PY - 2013/09/10/accepted PY - 2013/12/5/entrez PY - 2013/12/5/pubmed PY - 2014/8/20/medline KW - Antiviral activity KW - Chemical structure KW - Cryptonemia seminervis KW - Human metapneumovirus KW - Partial depolymerization KW - Sulfated galactans SP - 313 EP - 23 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 101 N2 - The anti-HMPV (human metapneumovirus) activity was determined for sulfated dl-hybrid galactans obtained from the red seaweed Cryptonemia seminervis and their depolymerized products obtained by reductive partial hydrolysis. Structural studies carried out in three homogeneous depolymerized fractions DS-1, DS-2e and DS-3 (Mw of 51.6-63.8 kDa) showed that these galactans present different chemical characteristics, as monosaccharide composition, content of sulfate groups (14.1-29.9%) and agaran:carrageenan molar ratio diads, 2.7:1 for DS-1 and DS-2e and 1:1 for DS-3. The sulfate groups are located principally on C-2 of β-d-galactopyranose and 4,6-O-(1'-carboxyethylidene)-β-d-galactopyranose residues and on C-6 of α-galactose residues. Sulfated dl-galactans and their depolymerized products exhibited antiviral activity at a very early stage of the viral infection cycle. All fractions, except DS-2e inhibited HMPV replication by binding to the viral particle. Besides depolymerized galactans DS-2e and DS-3 inhibited the recognition of cell receptor by HMPV and penetration to the host cell, respectively. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/24299779/Structure_and_anti_metapneumovirus_activity_of_sulfated_galactans_from_the_red_seaweed_Cryptonemia_seminervis_ DB - PRIME DP - Unbound Medicine ER -