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Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil.
Lipids Health Dis. 2013 Dec 05; 12:178.LH

Abstract

BACKGROUND

Due to structural differences, bioavailability of krill oil, a phospholipid based oil, could be higher than fish oil, a triglyceride-based oil, conferring properties that render it more effective than fish oil in increasing omega-3 index and thereby, reducing cardiovascular disease (CVD) risk.

OBJECTIVE

The objective was to assess the effects of krill oil compared with fish oil or a placebo control on plasma and red blood cell (RBC) fatty acid profile in healthy volunteers.

PARTICIPANTS AND METHODS

Twenty four healthy volunteers were recruited for a double blinded, randomized, placebo-controlled, crossover trial. The study consisted of three treatment phases including krill or fish oil each providing 600 mg of n-3 polyunsaturated fatty acids (PUFA) or placebo control, corn oil in capsule form. Each treatment lasted 4 wk and was separated by 8 wk washout phases.

RESULTS

Krill oil consumption increased plasma (p = 0.0043) and RBC (p = 0.0011) n-3 PUFA concentrations, including EPA and DHA, and reduced n-6:n-3 PUFA ratios (plasma: p = 0.0043, RBC: p = 0.0143) compared with fish oil consumption. Sum of EPA and DHA concentrations in RBC, the omega-3 index, was increased following krill oil supplementation compared with fish oil (p = 0.0143) and control (p < 0.0001). Serum triglycerides and HDL cholesterol concentrations did not change with any of the treatments. However, total and LDL cholesterol concentrations were increased following krill (TC: p = 0.0067, LDL: p = 0.0143) and fish oil supplementation (TC: p = 0.0028, LDL: p = 0.0143) compared with control.

CONCLUSIONS

Consumption of krill oil was well tolerated with no adverse events. Results indicate that krill oil could be more effective than fish oil in increasing n-3 PUFA, reducing n-6:n-3 PUFA ratio, and improving the omega-3 index.

TRIAL REGISTRATION

ClinicalTrials.gov, NCT01323036.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableRichardson Centre for Functional Foods and Nutraceuticals, Winnipeg, Canada. peter_jones@umanitoba.ca.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24304605

Citation

Ramprasath, Vanu R., et al. "Enhanced Increase of Omega-3 Index in Healthy Individuals With Response to 4-week N-3 Fatty Acid Supplementation From Krill Oil Versus Fish Oil." Lipids in Health and Disease, vol. 12, 2013, p. 178.
Ramprasath VR, Eyal I, Zchut S, et al. Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. Lipids Health Dis. 2013;12:178.
Ramprasath, V. R., Eyal, I., Zchut, S., & Jones, P. J. (2013). Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. Lipids in Health and Disease, 12, 178. https://doi.org/10.1186/1476-511X-12-178
Ramprasath VR, et al. Enhanced Increase of Omega-3 Index in Healthy Individuals With Response to 4-week N-3 Fatty Acid Supplementation From Krill Oil Versus Fish Oil. Lipids Health Dis. 2013 Dec 5;12:178. PubMed PMID: 24304605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. AU - Ramprasath,Vanu R, AU - Eyal,Inbal, AU - Zchut,Sigalit, AU - Jones,Peter J H, Y1 - 2013/12/05/ PY - 2013/09/18/received PY - 2013/11/19/accepted PY - 2013/12/6/entrez PY - 2013/12/7/pubmed PY - 2014/7/9/medline SP - 178 EP - 178 JF - Lipids in health and disease JO - Lipids Health Dis VL - 12 N2 - BACKGROUND: Due to structural differences, bioavailability of krill oil, a phospholipid based oil, could be higher than fish oil, a triglyceride-based oil, conferring properties that render it more effective than fish oil in increasing omega-3 index and thereby, reducing cardiovascular disease (CVD) risk. OBJECTIVE: The objective was to assess the effects of krill oil compared with fish oil or a placebo control on plasma and red blood cell (RBC) fatty acid profile in healthy volunteers. PARTICIPANTS AND METHODS: Twenty four healthy volunteers were recruited for a double blinded, randomized, placebo-controlled, crossover trial. The study consisted of three treatment phases including krill or fish oil each providing 600 mg of n-3 polyunsaturated fatty acids (PUFA) or placebo control, corn oil in capsule form. Each treatment lasted 4 wk and was separated by 8 wk washout phases. RESULTS: Krill oil consumption increased plasma (p = 0.0043) and RBC (p = 0.0011) n-3 PUFA concentrations, including EPA and DHA, and reduced n-6:n-3 PUFA ratios (plasma: p = 0.0043, RBC: p = 0.0143) compared with fish oil consumption. Sum of EPA and DHA concentrations in RBC, the omega-3 index, was increased following krill oil supplementation compared with fish oil (p = 0.0143) and control (p < 0.0001). Serum triglycerides and HDL cholesterol concentrations did not change with any of the treatments. However, total and LDL cholesterol concentrations were increased following krill (TC: p = 0.0067, LDL: p = 0.0143) and fish oil supplementation (TC: p = 0.0028, LDL: p = 0.0143) compared with control. CONCLUSIONS: Consumption of krill oil was well tolerated with no adverse events. Results indicate that krill oil could be more effective than fish oil in increasing n-3 PUFA, reducing n-6:n-3 PUFA ratio, and improving the omega-3 index. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01323036. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/24304605/Enhanced_increase_of_omega_3_index_in_healthy_individuals_with_response_to_4_week_n_3_fatty_acid_supplementation_from_krill_oil_versus_fish_oil_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-12-178 DB - PRIME DP - Unbound Medicine ER -