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[Structural-functional characteristics of argiopine--the ion channel blockers from the spider Argiope lobata venom].
Bioorg Khim. 1986 Aug; 12(8):1121-4.BK

Abstract

Argiopine, a compound capable of blocking the glutamate-activated ion channels in experiments with glutamatergic synapses of blowfly larvae, was isolated from the venom of spider Argiope lobata. Argiopine-receptor complex has KD 6,7 X 10(-7) M. The venom solution was treated with 60% ethanol, centrifuged and supernatant was subjected to reversed-phase HPLC in the acetonitrile concentration gradient. Argiopine structure was established using 1H- and 13C-NMR spectroscopy, mass spectrometry, elemental and amino acid analyses. Argiopine (molecular mass 636) consists of arginine (free alpha-NH2) linke with polyamine--NH (CH2)3NH(CH2)3NH(CH2)5NH--through a peptide bond. The polyamine is connected to the alpha-carboxyl group of asparagine whose alpha-amino group is linked to 2,4-dihydroxyphenylacetic acid.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

2430580

Citation

Grishin, E V., et al. "[Structural-functional Characteristics of Argiopine--the Ion Channel Blockers From the Spider Argiope Lobata Venom]." Bioorganicheskaia Khimiia, vol. 12, no. 8, 1986, pp. 1121-4.
Grishin EV, Volkova TM, Arsen'ev AS, et al. [Structural-functional characteristics of argiopine--the ion channel blockers from the spider Argiope lobata venom]. Bioorg Khim. 1986;12(8):1121-4.
Grishin, E. V., Volkova, T. M., Arsen'ev, A. S., Reshetova, O. S., & Onoprienko, V. V. (1986). [Structural-functional characteristics of argiopine--the ion channel blockers from the spider Argiope lobata venom]. Bioorganicheskaia Khimiia, 12(8), 1121-4.
Grishin EV, et al. [Structural-functional Characteristics of Argiopine--the Ion Channel Blockers From the Spider Argiope Lobata Venom]. Bioorg Khim. 1986;12(8):1121-4. PubMed PMID: 2430580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Structural-functional characteristics of argiopine--the ion channel blockers from the spider Argiope lobata venom]. AU - Grishin,E V, AU - Volkova,T M, AU - Arsen'ev,A S, AU - Reshetova,O S, AU - Onoprienko,V V, PY - 1986/8/1/pubmed PY - 1986/8/1/medline PY - 1986/8/1/entrez SP - 1121 EP - 4 JF - Bioorganicheskaia khimiia JO - Bioorg Khim VL - 12 IS - 8 N2 - Argiopine, a compound capable of blocking the glutamate-activated ion channels in experiments with glutamatergic synapses of blowfly larvae, was isolated from the venom of spider Argiope lobata. Argiopine-receptor complex has KD 6,7 X 10(-7) M. The venom solution was treated with 60% ethanol, centrifuged and supernatant was subjected to reversed-phase HPLC in the acetonitrile concentration gradient. Argiopine structure was established using 1H- and 13C-NMR spectroscopy, mass spectrometry, elemental and amino acid analyses. Argiopine (molecular mass 636) consists of arginine (free alpha-NH2) linke with polyamine--NH (CH2)3NH(CH2)3NH(CH2)5NH--through a peptide bond. The polyamine is connected to the alpha-carboxyl group of asparagine whose alpha-amino group is linked to 2,4-dihydroxyphenylacetic acid. SN - 0132-3423 UR - https://www.unboundmedicine.com/medline/citation/2430580/[Structural_functional_characteristics_of_argiopine__the_ion_channel_blockers_from_the_spider_Argiope_lobata_venom]_ DB - PRIME DP - Unbound Medicine ER -