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Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease.
Obes Res Clin Pract. 2013 Jul-Aug; 7(4):e275-83.OR

Abstract

AIM

The aim of this study was to investigate the relationships between 25-hydroxy-vitamin D (25(OH)D) and insulin resistance in obese adolescents with non-alcoholic fatty liver disease (NAFLD).

PATIENTS AND METHODS

Eighty-seven obese adolescents (45 girls and 42 boys, mean age: 12.7 ± 1.3 years, mean body mass index standard deviation score (BMI-SDS): 2.1 ± 0.3) and 30 lean subjects (15 girls and 15 boys, mean age: 12.3 ± 1.45 years, mean BMI-SDS: 0.5 ± 0.7) were enrolled for the study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminases (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for 25(OH)D, transaminases, glucose, and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR).

RESULTS

25(OH)D measurements were decreased in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group (29.5 ± 18.4 vs. 41.0 ± 17.9 vs. 48.1 ± 22.2 ng/mL). However; the NAFLD group had significantly lower measurements of 25(OH)D than the non-NAFLD group (p < 0.001) and lean group (p < 0.001). 25(OH)D was negatively correlated with HOMA-IR (r = 0.158, p = 0.01) and with alanine aminotransferase (r = 0.794, p = 0.03) in the NAFLD obese group. There was no significant associations between fasting insulin, BMI-SDS and 25(OH)D in obese groups.

CONCLUSION

We suggest that low 25(OH)D occurs commonly in obese adolescents with NAFLD and we demonstrated an association between insufficient vitamin D status and low insulin sensitivity in obese adolescents with NAFLD.

Authors+Show Affiliations

Department of Pediatric Endocrinology and Diabetes, Konya Research Hospital, Konya, Turkey. Electronic address:ozpirgon@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24306155

Citation

Pirgon, Ozgur, et al. "Low 25-hydroxyvitamin D Level Is Associated With Insulin Sensitivity in Obese Adolescents With Non-alcoholic Fatty Liver Disease." Obesity Research & Clinical Practice, vol. 7, no. 4, 2013, pp. e275-83.
Pirgon O, Cekmez F, Bilgin H, et al. Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease. Obes Res Clin Pract. 2013;7(4):e275-83.
Pirgon, O., Cekmez, F., Bilgin, H., Eren, E., & Dundar, B. (2013). Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease. Obesity Research & Clinical Practice, 7(4), e275-83. https://doi.org/10.1016/j.orcp.2012.01.004
Pirgon O, et al. Low 25-hydroxyvitamin D Level Is Associated With Insulin Sensitivity in Obese Adolescents With Non-alcoholic Fatty Liver Disease. Obes Res Clin Pract. 2013 Jul-Aug;7(4):e275-83. PubMed PMID: 24306155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease. AU - Pirgon,Ozgur, AU - Cekmez,Ferhat, AU - Bilgin,Huseyin, AU - Eren,Esra, AU - Dundar,Bumin, PY - 2011/12/19/received PY - 2012/01/25/revised PY - 2012/01/26/accepted PY - 2013/12/6/entrez PY - 2013/12/7/pubmed PY - 2014/7/30/medline SP - e275 EP - 83 JF - Obesity research & clinical practice JO - Obes Res Clin Pract VL - 7 IS - 4 N2 - AIM: The aim of this study was to investigate the relationships between 25-hydroxy-vitamin D (25(OH)D) and insulin resistance in obese adolescents with non-alcoholic fatty liver disease (NAFLD). PATIENTS AND METHODS: Eighty-seven obese adolescents (45 girls and 42 boys, mean age: 12.7 ± 1.3 years, mean body mass index standard deviation score (BMI-SDS): 2.1 ± 0.3) and 30 lean subjects (15 girls and 15 boys, mean age: 12.3 ± 1.45 years, mean BMI-SDS: 0.5 ± 0.7) were enrolled for the study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminases (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for 25(OH)D, transaminases, glucose, and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR). RESULTS: 25(OH)D measurements were decreased in both obese groups (NAFLD and non-NAFLD) in comparison with the lean group (29.5 ± 18.4 vs. 41.0 ± 17.9 vs. 48.1 ± 22.2 ng/mL). However; the NAFLD group had significantly lower measurements of 25(OH)D than the non-NAFLD group (p < 0.001) and lean group (p < 0.001). 25(OH)D was negatively correlated with HOMA-IR (r = 0.158, p = 0.01) and with alanine aminotransferase (r = 0.794, p = 0.03) in the NAFLD obese group. There was no significant associations between fasting insulin, BMI-SDS and 25(OH)D in obese groups. CONCLUSION: We suggest that low 25(OH)D occurs commonly in obese adolescents with NAFLD and we demonstrated an association between insufficient vitamin D status and low insulin sensitivity in obese adolescents with NAFLD. SN - 1871-403X UR - https://www.unboundmedicine.com/medline/citation/24306155/Low_25_hydroxyvitamin_D_level_is_associated_with_insulin_sensitivity_in_obese_adolescents_with_non_alcoholic_fatty_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-403X(12)00009-9 DB - PRIME DP - Unbound Medicine ER -