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Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study.
Obesity (Silver Spring). 2014 Jan; 22(1):5-13.O

Abstract

OBJECTIVE

To evaluate 8-year weight losses achieved with intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study.

DESIGN AND METHODS

Look AHEAD assessed the effects of intentional weight loss on cardiovascular morbidity and mortality in 5,145 overweight/obese adults with type 2 diabetes, randomly assigned to ILI or usual care (i.e., diabetes support and education [DSE]). The ILI provided comprehensive behavioral weight loss counseling over 8 years; DSE participants received periodic group education only.

RESULTS

All participants had the opportunity to complete 8 years of intervention before Look AHEAD was halted in September 2012; ≥88% of both groups completed the 8-year outcomes assessment. ILI and DSE participants lost (mean ± SE) 4.7% ± 0.2% and 2.1 ± 0.2% of initial weight, respectively (P < 0.001) at year 8; 50.3% and 35.7%, respectively, lost ≥5% (P < 0.001), and 26.9% and 17.2%, respectively, lost ≥10% (P < 0.001). Across the 8 years ILI participants, compared with DSE, reported greater practice of several key weight-control behaviors. These behaviors also distinguished ILI participants who lost ≥10% and kept it off from those who lost but regained.

CONCLUSIONS

Look AHEAD's ILI produced clinically meaningful weight loss (≥5%) at year 8 in 50% of patients with type 2 diabetes and can be used to manage other obesity-related co-morbid conditions.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24307184

Citation

Look AHEAD Research Group. "Eight-year Weight Losses With an Intensive Lifestyle Intervention: the Look AHEAD Study." Obesity (Silver Spring, Md.), vol. 22, no. 1, 2014, pp. 5-13.
Look AHEAD Research Group. Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity (Silver Spring). 2014;22(1):5-13.
Look AHEAD Research Group. (2014). Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity (Silver Spring, Md.), 22(1), 5-13. https://doi.org/10.1002/oby.20662
Look AHEAD Research Group. Eight-year Weight Losses With an Intensive Lifestyle Intervention: the Look AHEAD Study. Obesity (Silver Spring). 2014;22(1):5-13. PubMed PMID: 24307184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. A1 - ,, PY - 2013/10/28/received PY - 2013/10/30/accepted PY - 2013/12/6/entrez PY - 2013/12/7/pubmed PY - 2014/9/26/medline SP - 5 EP - 13 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 22 IS - 1 N2 - OBJECTIVE: To evaluate 8-year weight losses achieved with intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. DESIGN AND METHODS: Look AHEAD assessed the effects of intentional weight loss on cardiovascular morbidity and mortality in 5,145 overweight/obese adults with type 2 diabetes, randomly assigned to ILI or usual care (i.e., diabetes support and education [DSE]). The ILI provided comprehensive behavioral weight loss counseling over 8 years; DSE participants received periodic group education only. RESULTS: All participants had the opportunity to complete 8 years of intervention before Look AHEAD was halted in September 2012; ≥88% of both groups completed the 8-year outcomes assessment. ILI and DSE participants lost (mean ± SE) 4.7% ± 0.2% and 2.1 ± 0.2% of initial weight, respectively (P < 0.001) at year 8; 50.3% and 35.7%, respectively, lost ≥5% (P < 0.001), and 26.9% and 17.2%, respectively, lost ≥10% (P < 0.001). Across the 8 years ILI participants, compared with DSE, reported greater practice of several key weight-control behaviors. These behaviors also distinguished ILI participants who lost ≥10% and kept it off from those who lost but regained. CONCLUSIONS: Look AHEAD's ILI produced clinically meaningful weight loss (≥5%) at year 8 in 50% of patients with type 2 diabetes and can be used to manage other obesity-related co-morbid conditions. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/24307184/Eight_year_weight_losses_with_an_intensive_lifestyle_intervention:_the_look_AHEAD_study_ L2 - https://doi.org/10.1002/oby.20662 DB - PRIME DP - Unbound Medicine ER -