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Relationship between aortic pulse wave velocity, selected proinflammatory cytokines, and vascular calcification parameters in peritoneal dialysis patients.
J Hypertens 2014; 32(1):142-8JH

Abstract

INTRODUCTION

Vascular calcification and arterial stiffening are cardiovascular risk factors among chronic kidney disease patients. Elevated aortic pulse wave velocity (AoPWV) is an independent predictor of increased cardiovascular morbidity and mortality.

OBJECTIVES

The aim of the study was to analyze the relationships between inflammatory and vascular calcification parameters and arterial wall stiffness in chronic kidney disease (CKD) patients treated by peritoneal dialysis.

PATIENTS AND METHODS

The study included 57 patients (27 women and 30 men) aged from 19 to 75 years (mean age 53 ± 13), treated by peritoneal dialysis during 4-100 months (mean 30.4 months). The concentrations of albumin, lipids, interleukin-6 (IL-6), IL-18, high-sensitive C-reactive protein, transforming growth factor-β1 (TGF-β1), osteocalcin, osteoprotegerin (OPG), fibroblast growth factor 23, fetuin A, parathyroid hormone (iPTH), total calcium (Ca), and phosphates (Pi) were measured. AoPWV was performed using a tonometric method, common carotid artery intima-media thickness (CCA-IMT) by ultrasonography evaluation, and calcium scoring (CaSc) with multirow spiral computed tomography (MSCT).

RESULTS

In univariate analysis, AoPWV correlated negatively with osteocalcin (R = -0.37; P = 0.005) and positively with OPG (R = 0.41; P = 0.002). Additionally, AoPWV was significantly positively associated with inflammatory parameters: IL-6 (R = 0.35; P = 0.009), TGF-β1 (R = 0.27; P = 0.047), and white blood cell (WBC) count (R = 0.33; P = 0.01). There were also positive correlations between AoPWV and imaging data: CCA-IMT (R = 0.32; P = 0.02) and CaSc (R = 0.38; P = 0.004). AoPWV did not correlate with calcium, phosphate, Ca × Pi index, or iPTH concentration. After multiple adjustments, osteocalcin was the only significant predictor of AoPWV. In logistic regression adjusted for age, hypertension, and mean arterial pressure at AoPWV evaluation, only osteocalcin was significantly associated with high (above median) AoPWV values [odds ratio 0.96 (0.92-0.99) per unit increase in osteocalcin].

CONCLUSION

OPG concentration and some inflammatory markers (WBC count, IL-6, TGF-β1) influenced the severity of arterial wall stiffness in CKD patients. Measurement of osteocalcin seems to be the best predictor of AoPWV.

Authors+Show Affiliations

aDepartment of Nephrology bDepartment of Medical Diagnostics cDepartment of Internal Medicine and Gerontology dDepartment of Clinical Biochemistry, Jagiellonian University, Collegium Medicum, Cracow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24309487

Citation

Krzanowski, Marcin, et al. "Relationship Between Aortic Pulse Wave Velocity, Selected Proinflammatory Cytokines, and Vascular Calcification Parameters in Peritoneal Dialysis Patients." Journal of Hypertension, vol. 32, no. 1, 2014, pp. 142-8.
Krzanowski M, Janda K, Dumnicka P, et al. Relationship between aortic pulse wave velocity, selected proinflammatory cytokines, and vascular calcification parameters in peritoneal dialysis patients. J Hypertens. 2014;32(1):142-8.
Krzanowski, M., Janda, K., Dumnicka, P., Dubiel, M., Stompór, M., Kuśnierz-Cabala, B., ... Sułowicz, W. (2014). Relationship between aortic pulse wave velocity, selected proinflammatory cytokines, and vascular calcification parameters in peritoneal dialysis patients. Journal of Hypertension, 32(1), pp. 142-8. doi:10.1097/HJH.0b013e32836569c7.
Krzanowski M, et al. Relationship Between Aortic Pulse Wave Velocity, Selected Proinflammatory Cytokines, and Vascular Calcification Parameters in Peritoneal Dialysis Patients. J Hypertens. 2014;32(1):142-8. PubMed PMID: 24309487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between aortic pulse wave velocity, selected proinflammatory cytokines, and vascular calcification parameters in peritoneal dialysis patients. AU - Krzanowski,Marcin, AU - Janda,Katarzyna, AU - Dumnicka,Paulina, AU - Dubiel,Marzena, AU - Stompór,Małgorzata, AU - Kuśnierz-Cabala,Beata, AU - Grodzicki,Tomasz, AU - Sułowicz,Władysław, PY - 2013/12/7/entrez PY - 2013/12/7/pubmed PY - 2014/8/2/medline SP - 142 EP - 8 JF - Journal of hypertension JO - J. Hypertens. VL - 32 IS - 1 N2 - INTRODUCTION: Vascular calcification and arterial stiffening are cardiovascular risk factors among chronic kidney disease patients. Elevated aortic pulse wave velocity (AoPWV) is an independent predictor of increased cardiovascular morbidity and mortality. OBJECTIVES: The aim of the study was to analyze the relationships between inflammatory and vascular calcification parameters and arterial wall stiffness in chronic kidney disease (CKD) patients treated by peritoneal dialysis. PATIENTS AND METHODS: The study included 57 patients (27 women and 30 men) aged from 19 to 75 years (mean age 53 ± 13), treated by peritoneal dialysis during 4-100 months (mean 30.4 months). The concentrations of albumin, lipids, interleukin-6 (IL-6), IL-18, high-sensitive C-reactive protein, transforming growth factor-β1 (TGF-β1), osteocalcin, osteoprotegerin (OPG), fibroblast growth factor 23, fetuin A, parathyroid hormone (iPTH), total calcium (Ca), and phosphates (Pi) were measured. AoPWV was performed using a tonometric method, common carotid artery intima-media thickness (CCA-IMT) by ultrasonography evaluation, and calcium scoring (CaSc) with multirow spiral computed tomography (MSCT). RESULTS: In univariate analysis, AoPWV correlated negatively with osteocalcin (R = -0.37; P = 0.005) and positively with OPG (R = 0.41; P = 0.002). Additionally, AoPWV was significantly positively associated with inflammatory parameters: IL-6 (R = 0.35; P = 0.009), TGF-β1 (R = 0.27; P = 0.047), and white blood cell (WBC) count (R = 0.33; P = 0.01). There were also positive correlations between AoPWV and imaging data: CCA-IMT (R = 0.32; P = 0.02) and CaSc (R = 0.38; P = 0.004). AoPWV did not correlate with calcium, phosphate, Ca × Pi index, or iPTH concentration. After multiple adjustments, osteocalcin was the only significant predictor of AoPWV. In logistic regression adjusted for age, hypertension, and mean arterial pressure at AoPWV evaluation, only osteocalcin was significantly associated with high (above median) AoPWV values [odds ratio 0.96 (0.92-0.99) per unit increase in osteocalcin]. CONCLUSION: OPG concentration and some inflammatory markers (WBC count, IL-6, TGF-β1) influenced the severity of arterial wall stiffness in CKD patients. Measurement of osteocalcin seems to be the best predictor of AoPWV. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/24309487/Relationship_between_aortic_pulse_wave_velocity_selected_proinflammatory_cytokines_and_vascular_calcification_parameters_in_peritoneal_dialysis_patients_ L2 - http://dx.doi.org/10.1097/HJH.0b013e32836569c7 DB - PRIME DP - Unbound Medicine ER -