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Lethal herpesvirosis in 16 captive horned vipers (Vipera ammodytes ammodytes): pathological and ultrastructural findings.

Abstract

Sixteen captive adult horned vipers (Vipera ammodytes ammodytes) were submitted for necropsy examination following a 2-week history of lethargy, anorexia and dyspnoea. Gross lesions included widespread haemorrhage, serosanguineous effusions in the body cavities and multiple pinpoint white to yellow foci in the liver. Microscopically, there was multifocal hepatic coagulative necrosis associated with intranuclear acidophilic inclusion bodies in sinusoidal endothelial cells. Similar endothelial lesions were observed in the myocardium, fat bodies, kidneys and spleen. Transmission electron microscopy revealed numerous virions (100-110 nm) in the nuclei of endothelial cells and intracytoplasmic enveloped virions (140-150 nm) were also found. The gross and histological findings and the ultrastructural features of the intranuclear inclusions and viral particles were consistent with herpesviral infection. To the best of our knowledge, these are the first reported cases of a lethal herpesvirosis in horned vipers and the second report in snakes.

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  • Authors+Show Affiliations

    ,

    University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Pathology Department, 3-5 Calea Mãnãştur, 400372 Cluj-Napoca, Romania.

    ,

    University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Pathology Department, 3-5 Calea Mãnãştur, 400372 Cluj-Napoca, Romania.

    ,

    University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine, Pathology Department, 3-5 Calea Mãnãştur, 400372 Cluj-Napoca, Romania. Electronic address: taulescumarian@yahoo.com.

    ,

    School of Veterinary Science, The University of Queensland, Gatton Campus, 4343 Gatton, Queensland, Australia.

    Iuliu Haţieganu University of Medicine and Pharmacy, Department of Physiology, 13 Emil Isac Street, 400023 Cluj-Napoca, Romania.

    Source

    MeSH

    Animals
    Herpesviridae Infections
    Liver
    Viperidae
    Virion

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24309907

    Citation

    TY - JOUR T1 - Lethal herpesvirosis in 16 captive horned vipers (Vipera ammodytes ammodytes): pathological and ultrastructural findings. AU - Catoi,C, AU - Gal,A F, AU - Taulescu,M A, AU - Palmieri,C, AU - Catoi,A F, Y1 - 2013/10/14/ PY - 2013/08/16/received PY - 2013/09/05/revised PY - 2013/10/06/accepted PY - 2013/12/7/entrez PY - 2013/12/7/pubmed PY - 2014/11/19/medline KW - Vipera ammodytes KW - herpesvirus KW - inclusion bodies KW - transmission electron microscopy SP - 341 EP - 4 JF - Journal of comparative pathology JO - J. Comp. Pathol. VL - 150 IS - 2-3 N2 - Sixteen captive adult horned vipers (Vipera ammodytes ammodytes) were submitted for necropsy examination following a 2-week history of lethargy, anorexia and dyspnoea. Gross lesions included widespread haemorrhage, serosanguineous effusions in the body cavities and multiple pinpoint white to yellow foci in the liver. Microscopically, there was multifocal hepatic coagulative necrosis associated with intranuclear acidophilic inclusion bodies in sinusoidal endothelial cells. Similar endothelial lesions were observed in the myocardium, fat bodies, kidneys and spleen. Transmission electron microscopy revealed numerous virions (100-110 nm) in the nuclei of endothelial cells and intracytoplasmic enveloped virions (140-150 nm) were also found. The gross and histological findings and the ultrastructural features of the intranuclear inclusions and viral particles were consistent with herpesviral infection. To the best of our knowledge, these are the first reported cases of a lethal herpesvirosis in horned vipers and the second report in snakes. SN - 1532-3129 UR - https://www.unboundmedicine.com/medline/citation/24309907/Lethal_herpesvirosis_in_16_captive_horned_vipers__Vipera_ammodytes_ammodytes_:_pathological_and_ultrastructural_findings_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9975(13)00166-7 ER -