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A study on inhibitory effect of Spica prunellae extract on T lymphoma cell EL-4 tumour.

Abstract

The objective of the study was to investigate the in-vivo anti-tumour activity of Spica prunellae extract, and to preliminarily explore the possible mechanism of in-vivo anti-tumour effect of Spica prunellae extract. Tumour inhibition rate and tumour apoptosis-related protein status were determined using the mice model of transplanted T lymphoma cell EL-4 tumour, and by immunohistochemical method. The results revealed that Spica prunellae extract showed certain tumour inhibitory effect, and compared with the model group. Tumour weight in Spica prunellae high-dose group was highly significantly different (P<0.01). Tumour weight in Spica prunellae medium-dose group was also significantly different (P<0.05) compared with the model group. Spica prunellae high-dose group enabled the high expression of Bcl-2 protein (47.54%) and low expression of Bax protein (13.14%). The study concluded that Spica prunellae extract has certain in vivo anti-tumour effect, which may be achieved through regulation of apoptosis related proteins.

Authors+Show Affiliations

Department of General Surgery, the First Affiliated Hospital of Xinxiang Medical University, Wei Hui 453100, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24311843

Citation

Mao, Xingjiang, et al. "A Study On Inhibitory Effect of Spica Prunellae Extract On T Lymphoma Cell EL-4 Tumour." African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, vol. 10, no. 5, 2013, pp. 318-24.
Mao X, Wang G, Zhang W, et al. A study on inhibitory effect of Spica prunellae extract on T lymphoma cell EL-4 tumour. Afr J Tradit Complement Altern Med. 2013;10(5):318-24.
Mao, X., Wang, G., Zhang, W., & Li, S. (2013). A study on inhibitory effect of Spica prunellae extract on T lymphoma cell EL-4 tumour. African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, 10(5), pp. 318-24.
Mao X, et al. A Study On Inhibitory Effect of Spica Prunellae Extract On T Lymphoma Cell EL-4 Tumour. Afr J Tradit Complement Altern Med. 2013;10(5):318-24. PubMed PMID: 24311843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study on inhibitory effect of Spica prunellae extract on T lymphoma cell EL-4 tumour. AU - Mao,Xingjiang, AU - Wang,Gengfu, AU - Zhang,Wei, AU - Li,Shaoping, Y1 - 2013/08/12/ PY - 2013/12/7/entrez PY - 2013/12/7/pubmed PY - 2014/7/31/medline KW - EL-4 solid tumour KW - Spica prunellae KW - mechanism KW - tumour inhibition SP - 318 EP - 24 JF - African journal of traditional, complementary, and alternative medicines : AJTCAM JO - Afr J Tradit Complement Altern Med VL - 10 IS - 5 N2 - The objective of the study was to investigate the in-vivo anti-tumour activity of Spica prunellae extract, and to preliminarily explore the possible mechanism of in-vivo anti-tumour effect of Spica prunellae extract. Tumour inhibition rate and tumour apoptosis-related protein status were determined using the mice model of transplanted T lymphoma cell EL-4 tumour, and by immunohistochemical method. The results revealed that Spica prunellae extract showed certain tumour inhibitory effect, and compared with the model group. Tumour weight in Spica prunellae high-dose group was highly significantly different (P<0.01). Tumour weight in Spica prunellae medium-dose group was also significantly different (P<0.05) compared with the model group. Spica prunellae high-dose group enabled the high expression of Bcl-2 protein (47.54%) and low expression of Bax protein (13.14%). The study concluded that Spica prunellae extract has certain in vivo anti-tumour effect, which may be achieved through regulation of apoptosis related proteins. SN - 2505-0044 UR - https://www.unboundmedicine.com/medline/citation/24311843/A_study_on_inhibitory_effect_of_Spica_prunellae_extract_on_T_lymphoma_cell_EL_4_tumour_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24311843/ DB - PRIME DP - Unbound Medicine ER -