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Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30.
Scand J Immunol. 2014 Jan; 79(1):68-72.SJ

Abstract

We measured levels of pro-inflammatory cytokines in the cerebrospinal fluid (CSF) of patients with mumps meningitis, enteroviral echovirus 30 meningitis and children without central nervous system infection to investigate whether these molecules were involved in the pathogenesis of viral meningitis. The CSF was obtained from 62 children suspected with meningitis. These patients were classified to the mumps meningitis (n = 19), echovirus 30 meningitis (n = 22) and non-meningitis (n = 21) groups. The concentrations of interleukin-1 (IL-1), interleukin-1 soluble receptor type 2 (IL-1R2), interleukin-8 (IL-8), human interferon gamma (IFN-γ) and human tumour necrosis factor alpha (TNF-α) were determined by immunoassay. A significant increase was noted in the levels of IL-8, TNF-α and IL-1R2 in the CSF of both meningitis groups as compared to controls. The concentrations of IFN-γ and IL-1 differed significantly only between the mumps group and control. The levels of IL-1, IFN-γ and TNF-α were significantly higher in mumps meningitis when compared to the echovirus 30 group. Of all cytokines examined, only IFN-γ correlated with pleocytosis (r = 0.58) in the mumps meningitis group. The increased CSF cytokine levels are markers of meningeal inflammation, and each virus may cause a specific profile of the cytokine pattern.

Authors+Show Affiliations

Department of Pediatric Infectious Diseases, Medical University of Bialystok, Bialystok, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24313836

Citation

Sulik, A, et al. "Increased Levels of Cytokines in Cerebrospinal Fluid of Children With Aseptic Meningitis Caused By Mumps Virus and Echovirus 30." Scandinavian Journal of Immunology, vol. 79, no. 1, 2014, pp. 68-72.
Sulik A, Kroten A, Wojtkowska M, et al. Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30. Scand J Immunol. 2014;79(1):68-72.
Sulik, A., Kroten, A., Wojtkowska, M., & Oldak, E. (2014). Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30. Scandinavian Journal of Immunology, 79(1), 68-72. https://doi.org/10.1111/sji.12131
Sulik A, et al. Increased Levels of Cytokines in Cerebrospinal Fluid of Children With Aseptic Meningitis Caused By Mumps Virus and Echovirus 30. Scand J Immunol. 2014;79(1):68-72. PubMed PMID: 24313836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30. AU - Sulik,A, AU - Kroten,A, AU - Wojtkowska,M, AU - Oldak,E, PY - 2013/08/20/received PY - 2013/10/24/accepted PY - 2013/12/10/entrez PY - 2013/12/10/pubmed PY - 2014/2/26/medline SP - 68 EP - 72 JF - Scandinavian journal of immunology JO - Scand J Immunol VL - 79 IS - 1 N2 - We measured levels of pro-inflammatory cytokines in the cerebrospinal fluid (CSF) of patients with mumps meningitis, enteroviral echovirus 30 meningitis and children without central nervous system infection to investigate whether these molecules were involved in the pathogenesis of viral meningitis. The CSF was obtained from 62 children suspected with meningitis. These patients were classified to the mumps meningitis (n = 19), echovirus 30 meningitis (n = 22) and non-meningitis (n = 21) groups. The concentrations of interleukin-1 (IL-1), interleukin-1 soluble receptor type 2 (IL-1R2), interleukin-8 (IL-8), human interferon gamma (IFN-γ) and human tumour necrosis factor alpha (TNF-α) were determined by immunoassay. A significant increase was noted in the levels of IL-8, TNF-α and IL-1R2 in the CSF of both meningitis groups as compared to controls. The concentrations of IFN-γ and IL-1 differed significantly only between the mumps group and control. The levels of IL-1, IFN-γ and TNF-α were significantly higher in mumps meningitis when compared to the echovirus 30 group. Of all cytokines examined, only IFN-γ correlated with pleocytosis (r = 0.58) in the mumps meningitis group. The increased CSF cytokine levels are markers of meningeal inflammation, and each virus may cause a specific profile of the cytokine pattern. SN - 1365-3083 UR - https://www.unboundmedicine.com/medline/citation/24313836/Increased_levels_of_cytokines_in_cerebrospinal_fluid_of_children_with_aseptic_meningitis_caused_by_mumps_virus_and_echovirus_30_ L2 - https://doi.org/10.1111/sji.12131 DB - PRIME DP - Unbound Medicine ER -