TY - JOUR T1 - Novel insights of dietary polyphenols and obesity. AU - Wang,Shu, AU - Moustaid-Moussa,Naima, AU - Chen,Lixia, AU - Mo,Huanbiao, AU - Shastri,Anuradha, AU - Su,Rui, AU - Bapat,Priyanka, AU - Kwun,InSook, AU - Shen,Chwan-Li, PY - 2013/04/21/received PY - 2013/07/15/revised PY - 2013/09/04/accepted PY - 2013/12/10/entrez PY - 2013/12/10/pubmed PY - 2014/7/30/medline KW - ABCA1 KW - ACAT KW - ACC KW - AGP KW - AMPK KW - ATGL KW - Animal KW - Antioxidants KW - Apo KW - BMI KW - BW KW - C/EBPα KW - CCAAT/enhancer binding protein α KW - CPT-1 KW - CVD KW - Cell KW - DBP KW - Dietary polyphenols KW - EC KW - ECG KW - EGC KW - EGCG KW - FA KW - FABP4 KW - FAS KW - FASN KW - FFA KW - FFM KW - FM KW - FOXO1 KW - GPAT KW - GPX KW - GSSG KW - GTC KW - GTE KW - GTP KW - HDL-C KW - HF KW - HOMA-IR KW - HSL KW - Human KW - IFN KW - IGF-I KW - IL KW - LDL-C KW - LPL KW - LXR KW - MAPK KW - MCP-1 KW - MDA KW - MMP KW - Molecular mechanism KW - NF-κB KW - Obesity KW - PAI-1 KW - PDEs KW - PGC-1α KW - PON KW - PPARγ KW - RCT KW - ROS KW - SBP KW - SCD1 KW - SIRT1 KW - SOD KW - SREBP-1c KW - TBARS KW - TC KW - TG KW - TNF-α KW - UCP KW - aP2 KW - acetyl-coenzyme A carboxylase KW - acyl-coenzyme A: cholesterol acyltransferase KW - adenosine-monophosphate-activated protein kinase KW - adenosine-triphosphate-binding cassette A1 KW - adipocyte P2 protein, which is also known as aFABP, the adipocyte fatty acid binding protein or FAPB-4 KW - adipose triglyceride lipase KW - aminoalkyl glucosaminide 4-phosphate KW - apolipoprotein KW - body mass index KW - body weight KW - cAMP KW - cardiovascular disease KW - carnitine palmitoyltransferase-1 KW - cyclic adenosine monophosphate KW - diastolic blood pressure KW - epicatechin KW - epicatechin gallate KW - epigallocatechin KW - epigallocatechin gallate KW - fat mass KW - fat-free mass KW - fatty acid KW - fatty acid binding protein 4 KW - fatty acid synthase KW - forkhead box protein O1 KW - free fatty acid KW - glutathione disulfide KW - glutathione peroxidase KW - glycerol-3-phosphate acyltransferase KW - green tea catechin KW - green tea extracts KW - green tea polyphenols KW - high fat KW - high-density lipoprotein cholesterol KW - homeostasis model assessment of insulin resistance KW - hormone-sensitive lipase KW - insulin-like growth factor-I KW - interferon KW - interleukin KW - lipoprotein lipase KW - liver X receptor KW - low-density lipoprotein cholesterol KW - malondialdehyde KW - matrix metalloproteinase KW - mitogen-activated protein kinase KW - monocyte chemoattractant protein-1 KW - nuclear factor-κB KW - paraoxonase KW - peroxisome proliferator activator receptor γ KW - peroxisome proliferator-activated receptor gamma coactivator 1-alpha KW - phosphodiesterases KW - plasminogen activator inhibitor type 1 KW - randomized controlled trial KW - reactive oxygen species KW - sirtuin 1 KW - stearoyl-CoA desaturase-1 KW - sterol regulatory element-binding protein 1c KW - superoxide dismutase KW - systolic blood pressure KW - thiobarbituric acid reactive substances KW - total cholesterol KW - triglyceride KW - tumor necrosis factor-alpha KW - uncoupling protein SP - 1 EP - 18 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 25 IS - 1 N2 - The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here, we evaluated the impact of commonly consumed polyphenols, including green tea catechins, especially epigallocatechin gallates, resveratrol and curcumin, on obesity and obesity-related inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-κB that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area and are inconsistent about the antiobesity impact of dietary polyphenols probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight-reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/24314860/Novel_insights_of_dietary_polyphenols_and_obesity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(13)00161-7 DB - PRIME DP - Unbound Medicine ER -