TY - JOUR
T1 - Novel insights of dietary polyphenols and obesity.
AU - Wang,Shu,
AU - Moustaid-Moussa,Naima,
AU - Chen,Lixia,
AU - Mo,Huanbiao,
AU - Shastri,Anuradha,
AU - Su,Rui,
AU - Bapat,Priyanka,
AU - Kwun,InSook,
AU - Shen,Chwan-Li,
PY - 2013/04/21/received
PY - 2013/07/15/revised
PY - 2013/09/04/accepted
PY - 2013/12/10/entrez
PY - 2013/12/10/pubmed
PY - 2014/7/30/medline
KW - ABCA1
KW - ACAT
KW - ACC
KW - AGP
KW - AMPK
KW - ATGL
KW - Animal
KW - Antioxidants
KW - Apo
KW - BMI
KW - BW
KW - C/EBPα
KW - CCAAT/enhancer binding protein α
KW - CPT-1
KW - CVD
KW - Cell
KW - DBP
KW - Dietary polyphenols
KW - EC
KW - ECG
KW - EGC
KW - EGCG
KW - FA
KW - FABP4
KW - FAS
KW - FASN
KW - FFA
KW - FFM
KW - FM
KW - FOXO1
KW - GPAT
KW - GPX
KW - GSSG
KW - GTC
KW - GTE
KW - GTP
KW - HDL-C
KW - HF
KW - HOMA-IR
KW - HSL
KW - Human
KW - IFN
KW - IGF-I
KW - IL
KW - LDL-C
KW - LPL
KW - LXR
KW - MAPK
KW - MCP-1
KW - MDA
KW - MMP
KW - Molecular mechanism
KW - NF-κB
KW - Obesity
KW - PAI-1
KW - PDEs
KW - PGC-1α
KW - PON
KW - PPARγ
KW - RCT
KW - ROS
KW - SBP
KW - SCD1
KW - SIRT1
KW - SOD
KW - SREBP-1c
KW - TBARS
KW - TC
KW - TG
KW - TNF-α
KW - UCP
KW - aP2
KW - acetyl-coenzyme A carboxylase
KW - acyl-coenzyme A: cholesterol acyltransferase
KW - adenosine-monophosphate-activated protein kinase
KW - adenosine-triphosphate-binding cassette A1
KW - adipocyte P2 protein, which is also known as aFABP, the adipocyte fatty acid binding protein or FAPB-4
KW - adipose triglyceride lipase
KW - aminoalkyl glucosaminide 4-phosphate
KW - apolipoprotein
KW - body mass index
KW - body weight
KW - cAMP
KW - cardiovascular disease
KW - carnitine palmitoyltransferase-1
KW - cyclic adenosine monophosphate
KW - diastolic blood pressure
KW - epicatechin
KW - epicatechin gallate
KW - epigallocatechin
KW - epigallocatechin gallate
KW - fat mass
KW - fat-free mass
KW - fatty acid
KW - fatty acid binding protein 4
KW - fatty acid synthase
KW - forkhead box protein O1
KW - free fatty acid
KW - glutathione disulfide
KW - glutathione peroxidase
KW - glycerol-3-phosphate acyltransferase
KW - green tea catechin
KW - green tea extracts
KW - green tea polyphenols
KW - high fat
KW - high-density lipoprotein cholesterol
KW - homeostasis model assessment of insulin resistance
KW - hormone-sensitive lipase
KW - insulin-like growth factor-I
KW - interferon
KW - interleukin
KW - lipoprotein lipase
KW - liver X receptor
KW - low-density lipoprotein cholesterol
KW - malondialdehyde
KW - matrix metalloproteinase
KW - mitogen-activated protein kinase
KW - monocyte chemoattractant protein-1
KW - nuclear factor-κB
KW - paraoxonase
KW - peroxisome proliferator activator receptor γ
KW - peroxisome proliferator-activated receptor gamma coactivator 1-alpha
KW - phosphodiesterases
KW - plasminogen activator inhibitor type 1
KW - randomized controlled trial
KW - reactive oxygen species
KW - sirtuin 1
KW - stearoyl-CoA desaturase-1
KW - sterol regulatory element-binding protein 1c
KW - superoxide dismutase
KW - systolic blood pressure
KW - thiobarbituric acid reactive substances
KW - total cholesterol
KW - triglyceride
KW - tumor necrosis factor-alpha
KW - uncoupling protein
SP - 1
EP - 18
JF - The Journal of nutritional biochemistry
JO - J Nutr Biochem
VL - 25
IS - 1
N2 - The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here, we evaluated the impact of commonly consumed polyphenols, including green tea catechins, especially epigallocatechin gallates, resveratrol and curcumin, on obesity and obesity-related inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-κB that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area and are inconsistent about the antiobesity impact of dietary polyphenols probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight-reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.
SN - 1873-4847
UR - https://www.unboundmedicine.com/medline/citation/24314860/Novel_insights_of_dietary_polyphenols_and_obesity_
DB - PRIME
DP - Unbound Medicine
ER -
