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Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease.
Exp Gerontol. 2014 Feb; 50:95-105.EG

Abstract

Panax ginseng has been used in traditional Chinese medicine for centuries. Among its various benefits is a pluripotent targeting of the various events involved in neuronal cell death. This includes anti-inflammatory, anti-oxidant, and anti-apoptotic effects. Indeed, ginseng extract and its individual ginsenosides have been demonstrated to influence a number of biochemical markers implicated in Parkinson's disease (PD) pathogenesis. We have reported previously that administration of the ginseng extract, G115, afforded robust neuroprotection in two rodent models of PD. However, these traditional rodent models are acute in nature and do accurately recapitulate the progressive nature of the disease. Chronic exposure to the dietary phytosterol glucoside, β-sitosterol β-d-glucoside (BSSG) triggers the progressive development of neurological deficits, with behavioral and cellular features that closely approximate those observed in PD patients. Clinical signs and histopathology continue to develop for several months following cessation of exposure to the neurotoxic insult. Here, we utilized this model to further characterize the neuroprotective effects of the ginseng extract, G115. Oral administration of this extract significantly reduced dopaminergic cell loss, microgliosis, and accumulation of α-synuclein aggregates. Further, G115 administration fully prevented the development of locomotor deficits, in the form of reduced locomotor activity and coordination. These results suggest that ginseng extract may be a potential neuroprotective therapy for the treatment of PD.

Authors+Show Affiliations

Neurodyn Inc., 550 University Ave., Charlottetown, PE C1A 4P3, Canada; Department of Biomedical Science, University of Prince Edward Island, 550 University Ave., Charlottetown, PE C1A 4P3, Canada. Electronic address: jvankampen@neurodyn.ca.Neurodyn Inc., 550 University Ave., Charlottetown, PE C1A 4P3, Canada.Department of Ophthalmology and Visual Sciences, University of British Columbia, 828W. 10th Ave., Vancouver, BC V5Z 1L8, Canada.Neurodyn Inc., 550 University Ave., Charlottetown, PE C1A 4P3, Canada; Department of Biochemistry, University of Prince Edward Island.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24316034

Citation

Van Kampen, Jackalina M., et al. "Panax Ginseng Is Neuroprotective in a Novel Progressive Model of Parkinson's Disease." Experimental Gerontology, vol. 50, 2014, pp. 95-105.
Van Kampen JM, Baranowski DB, Shaw CA, et al. Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease. Exp Gerontol. 2014;50:95-105.
Van Kampen, J. M., Baranowski, D. B., Shaw, C. A., & Kay, D. G. (2014). Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease. Experimental Gerontology, 50, 95-105. https://doi.org/10.1016/j.exger.2013.11.012
Van Kampen JM, et al. Panax Ginseng Is Neuroprotective in a Novel Progressive Model of Parkinson's Disease. Exp Gerontol. 2014;50:95-105. PubMed PMID: 24316034.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease. AU - Van Kampen,Jackalina M, AU - Baranowski,David B, AU - Shaw,Christopher A, AU - Kay,Denis G, Y1 - 2013/12/03/ PY - 2013/07/31/received PY - 2013/11/18/revised PY - 2013/11/25/accepted PY - 2013/12/10/entrez PY - 2013/12/10/pubmed PY - 2014/9/17/medline KW - BSSG KW - DAT KW - Dopamine KW - ER KW - G115 KW - GRP KW - Ginseng KW - Neuroprotection KW - PD KW - Parkinson's disease KW - SNc KW - Substantia nigra KW - TH KW - TUNEL KW - UPR KW - dopamine transporter KW - endoplasmic reticulum KW - glucose-regulated protein KW - substantia nigra pars compacta KW - terminal deoxynucleotidyl transferase dUTP nick end labeling KW - tyrosine hydroxylase KW - unfolded protein response KW - α-Synuclein KW - β-sitosterol β-d-glucoside SP - 95 EP - 105 JF - Experimental gerontology JO - Exp Gerontol VL - 50 N2 - Panax ginseng has been used in traditional Chinese medicine for centuries. Among its various benefits is a pluripotent targeting of the various events involved in neuronal cell death. This includes anti-inflammatory, anti-oxidant, and anti-apoptotic effects. Indeed, ginseng extract and its individual ginsenosides have been demonstrated to influence a number of biochemical markers implicated in Parkinson's disease (PD) pathogenesis. We have reported previously that administration of the ginseng extract, G115, afforded robust neuroprotection in two rodent models of PD. However, these traditional rodent models are acute in nature and do accurately recapitulate the progressive nature of the disease. Chronic exposure to the dietary phytosterol glucoside, β-sitosterol β-d-glucoside (BSSG) triggers the progressive development of neurological deficits, with behavioral and cellular features that closely approximate those observed in PD patients. Clinical signs and histopathology continue to develop for several months following cessation of exposure to the neurotoxic insult. Here, we utilized this model to further characterize the neuroprotective effects of the ginseng extract, G115. Oral administration of this extract significantly reduced dopaminergic cell loss, microgliosis, and accumulation of α-synuclein aggregates. Further, G115 administration fully prevented the development of locomotor deficits, in the form of reduced locomotor activity and coordination. These results suggest that ginseng extract may be a potential neuroprotective therapy for the treatment of PD. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/24316034/Panax_ginseng_is_neuroprotective_in_a_novel_progressive_model_of_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -