Dietary protein is beneficial to bone health under conditions of adequate calcium intake: an update on clinical research.
PURPOSE OF REVIEWTo underscore recent clinical studies, which evaluate the association between dietary protein and bone health.
RECENT FINDINGSEpidemiologic studies show greater protein intake to be beneficial to bone health in adults. In addition, randomized controlled trials show that protein's positive effect on bone health is augmented by increased calcium intake. The relation between dietary protein and fracture risk is unclear. Dietary protein may positively impact bone health by increasing muscle mass, increasing calcium absorption, suppressing parathyroid hormone, and augmenting insulin-like growth factor 1 production; but the effects of other factors that contribute to this association, such as dietary protein dose and timing response, require further research.
SUMMARYThe positive effects of protein intake on bone health may only be beneficial under conditions of adequate calcium intake. Dietary protein's relation with fracture risk requires further investigation.
aThe Institute for Aging Research, Hebrew SeniorLife, Boston Massachusetts bDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts cDepartment of Allied Health Sciences, The University of Connecticut, Storrs, Connecticut, USA.,
MeSHBone and Bones
Insulin-Like Growth Factor I
Meta-Analysis as Topic
Randomized Controlled Trials as Topic
Pub Type(s)Journal Article
Research Support, N.I.H., Extramural