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Impact on long-term OS of conditioning regimen in allogeneic BMT for children with AML in first CR: TBI+CY versus BU+CY: a report from the Société Française de Greffe de Moelle et de Thérapie Cellulaire.
Bone Marrow Transplant. 2014 Mar; 49(3):382-8.BM

Abstract

Allogeneic hematopoietic SCT (HSCT) appears to be an efficient tool to cure high-risk AML in first CR but the choice between BU-based or TBI-based conditioning regimens still remains controversial. In order to analyze the impact of conditioning regimen on long-term survival, we conducted a retrospective analysis from French registry data including all consecutive patients under 18 years old (n=226) from 1980 to 2004 transplanted for AML in CR1 from sibling (n=142) or matched unrelated donors and given either TBI-1200 cGy and CY 120 mg/kg (TBI-Cy, n=84) or BU 16 mg/kg and CY 200 mg/kg (BuCy200, n=142). Patient subgroups were comparable for all criteria except for median age at diagnosis and HSCT and for donor type. Both 5-year OS and disease-free survival (DFS) were significantly better in BuCy200 group (P=0.02 and 0.005, respectively). In multivariate analysis, both HLA matching and BuCy200 appeared as good prognostic factors for treatment-related mortality and DFS. Grade 2-4 acute GvHD and chronic GvHD rates were statistically higher in TBI-Cy group than in Bu-Cy200 one with a RR at 2 (P=0.002). In total, Bu-Cy200 conditioning regimen gives better outcome compared with TBI-Cy irrespective of the stem cell source and the donor type.

Authors+Show Affiliations

Pediatric Hematology Department, Jeanne de Flandre Hospital, CHRU Lille, Lille, France.EA 2694, Faculté de Médecine, Lille, France.Pediatric Hematology and Oncology Department, Trousseau Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.Hematology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.Pediatric Hematology Department, Timone Hospital, Marseille, France.Pediatric Hematology and Oncology Unit, IHOP, Lyon, France.Pediatric Hematology and Oncology Department, CHU Nancy, Vandoeuvre-les-Nancy, France.1] Centre Hospitalier et Universitaire (CHU) de Nantes, Service d'Onco-Hématologie Pédiatrique, Nantes, France [2] Université de Nantes, Faculté de Médecine, Nantes, France.HSCT department, CHU Besançon, Besançon, France.Pediatric Hematology and Oncology Unit, CHU Rouen, Rouen, France.Pediatric Hematology and Oncology Unit, CHU Strasbourg, Strasbourg, France.Pediatric Hematology Department, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.EA 2694, Faculté de Médecine, Lille, France.Pediatric Hematology Department, Jeanne de Flandre Hospital, CHRU Lille, Lille, France.Pediatric Hematology Department, Timone Hospital, Marseille, France.1] Pediatric Hematology Department, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France [2] INSERM 1149, Paris Diderot University, Paris, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24317131

Citation

de Berranger, E, et al. "Impact On Long-term OS of Conditioning Regimen in Allogeneic BMT for Children With AML in First CR: TBI+CY Versus BU+CY: a Report From the Société Française De Greffe De Moelle Et De Thérapie Cellulaire." Bone Marrow Transplantation, vol. 49, no. 3, 2014, pp. 382-8.
de Berranger E, Cousien A, Petit A, et al. Impact on long-term OS of conditioning regimen in allogeneic BMT for children with AML in first CR: TBI+CY versus BU+CY: a report from the Société Française de Greffe de Moelle et de Thérapie Cellulaire. Bone Marrow Transplant. 2014;49(3):382-8.
de Berranger, E., Cousien, A., Petit, A., Peffault de Latour, R., Galambrun, C., Bertrand, Y., Salmon, A., Rialland, F., Rohrlich, P. S., Vannier, J. P., Lutz, P., Yakouben, K., Duhamel, A., Bruno, B., Michel, G., & Dalle, J. H. (2014). Impact on long-term OS of conditioning regimen in allogeneic BMT for children with AML in first CR: TBI+CY versus BU+CY: a report from the Société Française de Greffe de Moelle et de Thérapie Cellulaire. Bone Marrow Transplantation, 49(3), 382-8. https://doi.org/10.1038/bmt.2013.185
de Berranger E, et al. Impact On Long-term OS of Conditioning Regimen in Allogeneic BMT for Children With AML in First CR: TBI+CY Versus BU+CY: a Report From the Société Française De Greffe De Moelle Et De Thérapie Cellulaire. Bone Marrow Transplant. 2014;49(3):382-8. PubMed PMID: 24317131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact on long-term OS of conditioning regimen in allogeneic BMT for children with AML in first CR: TBI+CY versus BU+CY: a report from the Société Française de Greffe de Moelle et de Thérapie Cellulaire. AU - de Berranger,E, AU - Cousien,A, AU - Petit,A, AU - Peffault de Latour,R, AU - Galambrun,C, AU - Bertrand,Y, AU - Salmon,A, AU - Rialland,F, AU - Rohrlich,P-S, AU - Vannier,J-P, AU - Lutz,P, AU - Yakouben,K, AU - Duhamel,A, AU - Bruno,B, AU - Michel,G, AU - Dalle,J-H, Y1 - 2013/12/09/ PY - 2013/01/25/received PY - 2013/09/11/revised PY - 2013/09/14/accepted PY - 2013/12/10/entrez PY - 2013/12/10/pubmed PY - 2015/7/3/medline SP - 382 EP - 8 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 49 IS - 3 N2 - Allogeneic hematopoietic SCT (HSCT) appears to be an efficient tool to cure high-risk AML in first CR but the choice between BU-based or TBI-based conditioning regimens still remains controversial. In order to analyze the impact of conditioning regimen on long-term survival, we conducted a retrospective analysis from French registry data including all consecutive patients under 18 years old (n=226) from 1980 to 2004 transplanted for AML in CR1 from sibling (n=142) or matched unrelated donors and given either TBI-1200 cGy and CY 120 mg/kg (TBI-Cy, n=84) or BU 16 mg/kg and CY 200 mg/kg (BuCy200, n=142). Patient subgroups were comparable for all criteria except for median age at diagnosis and HSCT and for donor type. Both 5-year OS and disease-free survival (DFS) were significantly better in BuCy200 group (P=0.02 and 0.005, respectively). In multivariate analysis, both HLA matching and BuCy200 appeared as good prognostic factors for treatment-related mortality and DFS. Grade 2-4 acute GvHD and chronic GvHD rates were statistically higher in TBI-Cy group than in Bu-Cy200 one with a RR at 2 (P=0.002). In total, Bu-Cy200 conditioning regimen gives better outcome compared with TBI-Cy irrespective of the stem cell source and the donor type. SN - 1476-5365 UR - https://www.unboundmedicine.com/medline/citation/24317131/Impact_on_long_term_OS_of_conditioning_regimen_in_allogeneic_BMT_for_children_with_AML_in_first_CR:_TBI+CY_versus_BU+CY:_a_report_from_the_Société_Française_de_Greffe_de_Moelle_et_de_Thérapie_Cellulaire_ L2 - https://doi.org/10.1038/bmt.2013.185 DB - PRIME DP - Unbound Medicine ER -