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An unusual case of transient neonatal pustular melanosis: a diagnostic puzzle.
Eur J Pediatr. 2014 Dec; 173(12):1655-8.EJ

Abstract

A newborn's skin may exhibit a variety of changes during the first weeks of life, and rashes are extremely common in the neonatal period, representing a significant source of parental concern. In particular, a variety of skin eruptions can present as pustules. Most of them are innocuous and self-limiting, while others can be the manifestation of an infectious disease or even indicative of serious underlying disorders. Transient neonatal pustular melanosis is an uncommon vesiculopustular rash characterized by small pustules on a non-erythematous base, noted at birth or during the first day of life, without systemic symptoms. The lesions rupture spontaneously, leaving hyperpigmented macules that usually fade within few weeks. Clinical recognition of this disease can help physicians avoid unnecessary diagnostic testing and treatment for infectious etiologies because no specific therapy is recommended. The clinical aspect and time of onset are generally sufficient to make the correct diagnosis. Nevertheless, peculiar clinical presentations may require additional work-up to rule out life-threatening conditions, and dermatological consultation and histological examination are required for the final diagnosis.

CONCLUSION

We report an exceedingly unusual presentation of transient neonatal pustular melanosis, suggesting the importance of a systematic diagnostic approach to allow a confident recognition of this benign condition.

Authors+Show Affiliations

Department of Clinical-Surgical, Diagnostic and Paediatric Sciences, Institute of Dermatology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy, vbrazzelli@libero.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24318488

Citation

Brazzelli, Valeria, et al. "An Unusual Case of Transient Neonatal Pustular Melanosis: a Diagnostic Puzzle." European Journal of Pediatrics, vol. 173, no. 12, 2014, pp. 1655-8.
Brazzelli V, Grasso V, Croci G, et al. An unusual case of transient neonatal pustular melanosis: a diagnostic puzzle. Eur J Pediatr. 2014;173(12):1655-8.
Brazzelli, V., Grasso, V., Croci, G., Figar, T., & Borroni, G. (2014). An unusual case of transient neonatal pustular melanosis: a diagnostic puzzle. European Journal of Pediatrics, 173(12), 1655-8. https://doi.org/10.1007/s00431-013-2227-9
Brazzelli V, et al. An Unusual Case of Transient Neonatal Pustular Melanosis: a Diagnostic Puzzle. Eur J Pediatr. 2014;173(12):1655-8. PubMed PMID: 24318488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An unusual case of transient neonatal pustular melanosis: a diagnostic puzzle. AU - Brazzelli,Valeria, AU - Grasso,Vincenzo, AU - Croci,Giorgio, AU - Figar,Tiziana, AU - Borroni,Giovanni, Y1 - 2013/12/07/ PY - 2013/09/25/received PY - 2013/11/21/accepted PY - 2013/12/10/entrez PY - 2013/12/10/pubmed PY - 2015/7/22/medline SP - 1655 EP - 8 JF - European journal of pediatrics JO - Eur J Pediatr VL - 173 IS - 12 N2 - UNLABELLED: A newborn's skin may exhibit a variety of changes during the first weeks of life, and rashes are extremely common in the neonatal period, representing a significant source of parental concern. In particular, a variety of skin eruptions can present as pustules. Most of them are innocuous and self-limiting, while others can be the manifestation of an infectious disease or even indicative of serious underlying disorders. Transient neonatal pustular melanosis is an uncommon vesiculopustular rash characterized by small pustules on a non-erythematous base, noted at birth or during the first day of life, without systemic symptoms. The lesions rupture spontaneously, leaving hyperpigmented macules that usually fade within few weeks. Clinical recognition of this disease can help physicians avoid unnecessary diagnostic testing and treatment for infectious etiologies because no specific therapy is recommended. The clinical aspect and time of onset are generally sufficient to make the correct diagnosis. Nevertheless, peculiar clinical presentations may require additional work-up to rule out life-threatening conditions, and dermatological consultation and histological examination are required for the final diagnosis. CONCLUSION: We report an exceedingly unusual presentation of transient neonatal pustular melanosis, suggesting the importance of a systematic diagnostic approach to allow a confident recognition of this benign condition. SN - 1432-1076 UR - https://www.unboundmedicine.com/medline/citation/24318488/An_unusual_case_of_transient_neonatal_pustular_melanosis:_a_diagnostic_puzzle_ L2 - https://dx.doi.org/10.1007/s00431-013-2227-9 DB - PRIME DP - Unbound Medicine ER -