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Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties.
J Asian Nat Prod Res. 2014; 16(3):248-53.JA

Abstract

Two new sesquiterpene lactones, namely feruhodin A and feruhodin B, together with six known compounds, daucoeudesmanolactone, dehydrooopodin, oopodin, badkhysin, 7-demethylplastochromenol, and scoparone, were isolated from the roots of Ferula oopoda. The structures of these compounds were elucidated by 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Cytotoxic effects of these compounds were evaluated against two human cancer cell lines including MCF7and K562 using the Alamar blue assay. The results showed that dehydrooopodin possessed significant cytotoxic effects with IC₅₀ values of 15 and 5 μM against MCF7 and K562, respectively.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Kasaian J
a Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences , Mashhad , Iran.
Iranshahy M
No affiliation info available
Masullo M
No affiliation info available
Piacente S
No affiliation info available
Ebrahimi F
No affiliation info available
Iranshahi M
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCoumarinsDrug Screening Assays, AntitumorFemaleFerulaHumansIranK562 CellsLactonesMCF-7 CellsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant RootsSesquiterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24320993

Citation

Kasaian, Jamal, et al. "Sesquiterpene Lactones From Ferula Oopoda and Their Cytotoxic Properties." Journal of Asian Natural Products Research, vol. 16, no. 3, 2014, pp. 248-53.
Kasaian J, Iranshahy M, Masullo M, et al. Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties. J Asian Nat Prod Res. 2014;16(3):248-53.
Kasaian, J., Iranshahy, M., Masullo, M., Piacente, S., Ebrahimi, F., & Iranshahi, M. (2014). Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties. Journal of Asian Natural Products Research, 16(3), 248-53. https://doi.org/10.1080/10286020.2013.866099
Kasaian J, et al. Sesquiterpene Lactones From Ferula Oopoda and Their Cytotoxic Properties. J Asian Nat Prod Res. 2014;16(3):248-53. PubMed PMID: 24320993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene lactones from Ferula oopoda and their cytotoxic properties. AU - Kasaian,Jamal, AU - Iranshahy,Milad, AU - Masullo,Milena, AU - Piacente,Sonia, AU - Ebrahimi,Fatemeh, AU - Iranshahi,Mehrdad, Y1 - 2013/12/10/ PY - 2013/12/11/entrez PY - 2013/12/11/pubmed PY - 2014/3/29/medline SP - 248 EP - 53 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 16 IS - 3 N2 - Two new sesquiterpene lactones, namely feruhodin A and feruhodin B, together with six known compounds, daucoeudesmanolactone, dehydrooopodin, oopodin, badkhysin, 7-demethylplastochromenol, and scoparone, were isolated from the roots of Ferula oopoda. The structures of these compounds were elucidated by 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Cytotoxic effects of these compounds were evaluated against two human cancer cell lines including MCF7and K562 using the Alamar blue assay. The results showed that dehydrooopodin possessed significant cytotoxic effects with IC₅₀ values of 15 and 5 μM against MCF7 and K562, respectively. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/24320993/Sesquiterpene_lactones_from_Ferula_oopoda_and_their_cytotoxic_properties_ DB - PRIME DP - Unbound Medicine ER -