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Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease.
J Neuroimaging. 2015 Jan-Feb; 25(1):105-10.JN

Abstract

BACKGROUND AND PURPOSE

Cerebral mitochondrial dysfunction has been observed in Parkinson's disease (PD). If mitochondrial dysfunction is an early event contributing to PD development, then noninvasive techniques that detect disturbed energy metabolism in vivo might be useful tools for early diagnosis and treatment monitoring. In the present study, we tested the hypothesis that proton ((1) H) and phosphorus ((31) P) magnetic resonance spectroscopy (MRS) measures of brain metabolites are able to differentiate between individuals with early PD and healthy volunteers (HVs).

METHODS

During this cross-sectional study including 20 subjects with early PD and 15 age-matched HV, ventricular lactate (anaerobic glycolysis); and regional levels of N-acetylaspartate (neuronal integrity); choline (membrane turnover); creatine (energy metabolism); ATP and other phosphate-containing compounds (oxidative phosphorylation) were determined using brain (1) H and (31) P MRS.

RESULTS

No metabolic abnormalities were detectable in early-stage PD patients. Metabolite concentrations were not related to age, disease duration, or Unified Parkinson's Disease Rating Scale motor scores.

DISCUSSION

In early PD, neither (1) H nor (31) P MRS were able to detect metabolic abnormalities, a finding that is in contrast to published data in more advanced PD cohorts. MRS under dynamic conditions might uncover latent energy deficits in early PD, thus warranting future study.

Authors+Show Affiliations

Department of Radiology, Weill Cornell Medical College, New York, NY.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24325203

Citation

Weiduschat, Nora, et al. "Usefulness of Proton and Phosphorus MR Spectroscopic Imaging for Early Diagnosis of Parkinson's Disease." Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, vol. 25, no. 1, 2015, pp. 105-10.
Weiduschat N, Mao X, Beal MF, et al. Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease. J Neuroimaging. 2015;25(1):105-10.
Weiduschat, N., Mao, X., Beal, M. F., Nirenberg, M. J., Shungu, D. C., & Henchcliffe, C. (2015). Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, 25(1), 105-10. https://doi.org/10.1111/jon.12074
Weiduschat N, et al. Usefulness of Proton and Phosphorus MR Spectroscopic Imaging for Early Diagnosis of Parkinson's Disease. J Neuroimaging. 2015 Jan-Feb;25(1):105-10. PubMed PMID: 24325203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease. AU - Weiduschat,Nora, AU - Mao,Xiangling, AU - Beal,M Flint, AU - Nirenberg,Melissa J, AU - Shungu,Dikoma C, AU - Henchcliffe,Claire, Y1 - 2013/12/10/ PY - 2013/05/26/received PY - 2013/08/16/revised PY - 2013/09/29/accepted PY - 2013/12/12/entrez PY - 2013/12/12/pubmed PY - 2015/9/22/medline KW - Magnetic resonance spectroscopy KW - Parkinson's disease KW - biomarker KW - diagnosis KW - mitochondrial dysfunction SP - 105 EP - 10 JF - Journal of neuroimaging : official journal of the American Society of Neuroimaging JO - J Neuroimaging VL - 25 IS - 1 N2 - BACKGROUND AND PURPOSE: Cerebral mitochondrial dysfunction has been observed in Parkinson's disease (PD). If mitochondrial dysfunction is an early event contributing to PD development, then noninvasive techniques that detect disturbed energy metabolism in vivo might be useful tools for early diagnosis and treatment monitoring. In the present study, we tested the hypothesis that proton ((1) H) and phosphorus ((31) P) magnetic resonance spectroscopy (MRS) measures of brain metabolites are able to differentiate between individuals with early PD and healthy volunteers (HVs). METHODS: During this cross-sectional study including 20 subjects with early PD and 15 age-matched HV, ventricular lactate (anaerobic glycolysis); and regional levels of N-acetylaspartate (neuronal integrity); choline (membrane turnover); creatine (energy metabolism); ATP and other phosphate-containing compounds (oxidative phosphorylation) were determined using brain (1) H and (31) P MRS. RESULTS: No metabolic abnormalities were detectable in early-stage PD patients. Metabolite concentrations were not related to age, disease duration, or Unified Parkinson's Disease Rating Scale motor scores. DISCUSSION: In early PD, neither (1) H nor (31) P MRS were able to detect metabolic abnormalities, a finding that is in contrast to published data in more advanced PD cohorts. MRS under dynamic conditions might uncover latent energy deficits in early PD, thus warranting future study. SN - 1552-6569 UR - https://www.unboundmedicine.com/medline/citation/24325203/Usefulness_of_proton_and_phosphorus_MR_spectroscopic_imaging_for_early_diagnosis_of_Parkinson's_disease_ L2 - https://doi.org/10.1111/jon.12074 DB - PRIME DP - Unbound Medicine ER -