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Significance of imbalance in the ratio of serum n-3 to n-6 polyunsaturated fatty acids in patients with acute coronary syndrome.
Am J Cardiol. 2014 Feb 01; 113(3):441-5.AJ

Abstract

This study aimed to assess the balance of serum n-3 to n-6 polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS). We enrolled 1,119 patients who were treated and in whom serum PUFA level was evaluated in 5 divisions of cardiology in a metropolitan area in Japan. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA), were compared between patients with and without ACS. We also evaluated the balance of serum n-3 to n-6 PUFAs, including EPA/AA and DHA/AA ratios. EPA/AA values were 0.46 ± 0.32 and 0.50 ± 0.32 in the ACS and non-ACS groups, respectively. DHA/AA values were 0.95 ± 0.37 and 0.96 ± 0.41 in the ACS and non-ACS groups, respectively. Next, we divided the patients into 3 groups based on the tertiles of EPA/AA or tertiles of DHA/AA to determine the independent risk factors for ACS. According to multivariate logistic regression analysis, the group with the lowest EPA/AA (≤0.33) had a greater probability of ACS (odds ratio 3.14, 95% confidence interval 1.16 to 8.49), but this was not true for DHA/AA. In conclusion, an imbalance in the ratio of serum EPA to AA, but not in the ratio of DHA to AA, was significantly associated with ACS.

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Authors+Show Affiliations

Nishizaki Y
Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Shimada K
Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Tani S
Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.
Ogawa T
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Ando J
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takahashi M
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yamamoto M
Department of Cardiology, Sempo Takanawa Hospital, Tokyo, Japan.
Shinozaki T
Department of Biostatistics, Graduate School of Public Health, The University of Tokyo, Tokyo, Japan.
Miyauchi K
Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Nagao K
Department of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.
Hirayama A
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Yoshimura M
Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Komuro I
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Nagai R
Jichi Medical University, Tochigi, Japan.
Daida H
Department of Cardiology, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: daida@juntendo.ac.jp.

MeSH

Acute Coronary SyndromeAgedBiomarkersFatty Acids, Omega-3Fatty Acids, Omega-6FemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk Factors

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

24326273

Citation

Nishizaki, Yuji, et al. "Significance of Imbalance in the Ratio of Serum N-3 to N-6 Polyunsaturated Fatty Acids in Patients With Acute Coronary Syndrome." The American Journal of Cardiology, vol. 113, no. 3, 2014, pp. 441-5.
Nishizaki Y, Shimada K, Tani S, et al. Significance of imbalance in the ratio of serum n-3 to n-6 polyunsaturated fatty acids in patients with acute coronary syndrome. Am J Cardiol. 2014;113(3):441-5.
Nishizaki, Y., Shimada, K., Tani, S., Ogawa, T., Ando, J., Takahashi, M., Yamamoto, M., Shinozaki, T., Miyauchi, K., Nagao, K., Hirayama, A., Yoshimura, M., Komuro, I., Nagai, R., & Daida, H. (2014). Significance of imbalance in the ratio of serum n-3 to n-6 polyunsaturated fatty acids in patients with acute coronary syndrome. The American Journal of Cardiology, 113(3), 441-5. https://doi.org/10.1016/j.amjcard.2013.10.011
Nishizaki Y, et al. Significance of Imbalance in the Ratio of Serum N-3 to N-6 Polyunsaturated Fatty Acids in Patients With Acute Coronary Syndrome. Am J Cardiol. 2014 Feb 1;113(3):441-5. PubMed PMID: 24326273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of imbalance in the ratio of serum n-3 to n-6 polyunsaturated fatty acids in patients with acute coronary syndrome. AU - Nishizaki,Yuji, AU - Shimada,Kazunori, AU - Tani,Shigemasa, AU - Ogawa,Takayuki, AU - Ando,Jiro, AU - Takahashi,Masao, AU - Yamamoto,Masato, AU - Shinozaki,Tomohiro, AU - Miyauchi,Katsumi, AU - Nagao,Ken, AU - Hirayama,Atsushi, AU - Yoshimura,Michihiro, AU - Komuro,Issei, AU - Nagai,Ryozo, AU - Daida,Hiroyuki, Y1 - 2013/11/07/ PY - 2013/08/04/received PY - 2013/10/15/revised PY - 2013/10/15/accepted PY - 2013/12/12/entrez PY - 2013/12/12/pubmed PY - 2014/3/19/medline SP - 441 EP - 5 JF - The American journal of cardiology JO - Am J Cardiol VL - 113 IS - 3 N2 - This study aimed to assess the balance of serum n-3 to n-6 polyunsaturated fatty acids (PUFAs) in patients with acute coronary syndrome (ACS). We enrolled 1,119 patients who were treated and in whom serum PUFA level was evaluated in 5 divisions of cardiology in a metropolitan area in Japan. Serum levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA), were compared between patients with and without ACS. We also evaluated the balance of serum n-3 to n-6 PUFAs, including EPA/AA and DHA/AA ratios. EPA/AA values were 0.46 ± 0.32 and 0.50 ± 0.32 in the ACS and non-ACS groups, respectively. DHA/AA values were 0.95 ± 0.37 and 0.96 ± 0.41 in the ACS and non-ACS groups, respectively. Next, we divided the patients into 3 groups based on the tertiles of EPA/AA or tertiles of DHA/AA to determine the independent risk factors for ACS. According to multivariate logistic regression analysis, the group with the lowest EPA/AA (≤0.33) had a greater probability of ACS (odds ratio 3.14, 95% confidence interval 1.16 to 8.49), but this was not true for DHA/AA. In conclusion, an imbalance in the ratio of serum EPA to AA, but not in the ratio of DHA to AA, was significantly associated with ACS. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/24326273/Significance_of_imbalance_in_the_ratio_of_serum_n_3_to_n_6_polyunsaturated_fatty_acids_in_patients_with_acute_coronary_syndrome_ DB - PRIME DP - Unbound Medicine ER -