TY - JOUR T1 - Mast-cell-mediated angiogenesis: a novel experimental model using the rat mesentery. AU - Norrby,K, AU - Jakobsson,A, AU - Sörbo,J, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 195 EP - 206 JF - Virchows Archiv. B, Cell pathology including molecular pathology JO - Virchows Arch B Cell Pathol Incl Mol Pathol VL - 52 IS - 3 N2 - The angiogenic effect of autogenous secreting mast cells (MCs) was studied using a novel experimental approach. The virtually avascular membranous rat mesentery was used as test tissue. The activation of MCs was elicited by repeated intraperitoneal injections of the MC-secretagogue compound 48/80, which per se appears inert from the proliferogenic and angiogenic point of view. Angiogenesis was quantitated histologically and expressed the number of vessels/unit length of mesentery. The smallest vessels recognized had a luminal area of approximately 7-8 microns 2 (corresponding to a circular diameter of 3.0-3.2 microns). Seven to ten days after MC-activation ended, the number of blood vessels had increased 7- to 6-fold. A retrogressive reaction occurred between days 21 and 38 after treatment, when the number of vessels had essentially normalized, as compared to vehicle-treated controls. The present study, introducing the membranous mesentery as a model for quantitative angiogenetic studies, provides evidence that MCs can induce angiogenesis, which is new. The possible therapeutic implication of this finding is noteworthy. SN - 0340-6075 UR - https://www.unboundmedicine.com/medline/citation/2432725/Mast_cell_mediated_angiogenesis:_a_novel_experimental_model_using_the_rat_mesentery_ DB - PRIME DP - Unbound Medicine ER -