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The contribution of systemic Escherichia coli infection to the early mortalities of commercial broiler chickens.
Avian Pathol. 2014; 43(1):37-42.AP

Abstract

Avian pathogenic Escherichia coli (APEC) are a substantial burden to the global poultry industry. APEC cause a syndromic poultry infection known as colibacillosis, which has been previously associated with broiler chickens over 2 weeks old. We recently reported that the intestinal tract of 1-day-old broilers harbours a rich reservoir of potentially pathogenic E. coli. Prior infections of the reproductive tract of breeders, egg hygiene and transportation all contribute to early colonization of the neonatal gut. Up to one-half of all flock deaths occur in the first week of production, but few data are available describing the contribution of E. coli. In the present study, all dead birds collected on the first daily welfare walk 48 and 72 h after chick placement underwent post-mortem examination. Diseased tissues were selectively cultured for E. coli and isolates subsequently virulotyped using 10 APEC virulence-associated genes (VAGs): astA, iss, irp2, iucD, papC, tsh, vat, cvi, sitA and ibeA. Approximately 70% of birds displayed signs of colibacillosis. Thirty distinct virulence profiles were identified among 157 E. coli. Isolates carried between zero and seven VAGs; ∼ 30% of E. coli isolates carried five to seven VAGs, with 12.7% sharing the same VAG profile (astA, iss, irp2, iucD, tsh, cvi and sitA). Overall, this study demonstrates the significant contribution of E. coli infections to early broiler mortalities. The identification of a diverse E. coli population is unsurprising based on our previous findings. This work emphasizes the need for an effective vaccination programme and provides preliminary data for vaccine production.

Authors+Show Affiliations

a Zoonotic Infections of People, Pigs and Poultry Group , Institute of Infection & Global Health and School of Veterinary Science, University of Liverpool , Leahurst Campus, Neston , UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24328462

Citation

Kemmett, K, et al. "The Contribution of Systemic Escherichia Coli Infection to the Early Mortalities of Commercial Broiler Chickens." Avian Pathology : Journal of the W.V.P.A, vol. 43, no. 1, 2014, pp. 37-42.
Kemmett K, Williams NJ, Chaloner G, et al. The contribution of systemic Escherichia coli infection to the early mortalities of commercial broiler chickens. Avian Pathol. 2014;43(1):37-42.
Kemmett, K., Williams, N. J., Chaloner, G., Humphrey, S., Wigley, P., & Humphrey, T. (2014). The contribution of systemic Escherichia coli infection to the early mortalities of commercial broiler chickens. Avian Pathology : Journal of the W.V.P.A, 43(1), 37-42. https://doi.org/10.1080/03079457.2013.866213
Kemmett K, et al. The Contribution of Systemic Escherichia Coli Infection to the Early Mortalities of Commercial Broiler Chickens. Avian Pathol. 2014;43(1):37-42. PubMed PMID: 24328462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The contribution of systemic Escherichia coli infection to the early mortalities of commercial broiler chickens. AU - Kemmett,K, AU - Williams,N J, AU - Chaloner,G, AU - Humphrey,S, AU - Wigley,P, AU - Humphrey,T, Y1 - 2013/12/16/ PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/9/30/medline SP - 37 EP - 42 JF - Avian pathology : journal of the W.V.P.A JO - Avian Pathol. VL - 43 IS - 1 N2 - Avian pathogenic Escherichia coli (APEC) are a substantial burden to the global poultry industry. APEC cause a syndromic poultry infection known as colibacillosis, which has been previously associated with broiler chickens over 2 weeks old. We recently reported that the intestinal tract of 1-day-old broilers harbours a rich reservoir of potentially pathogenic E. coli. Prior infections of the reproductive tract of breeders, egg hygiene and transportation all contribute to early colonization of the neonatal gut. Up to one-half of all flock deaths occur in the first week of production, but few data are available describing the contribution of E. coli. In the present study, all dead birds collected on the first daily welfare walk 48 and 72 h after chick placement underwent post-mortem examination. Diseased tissues were selectively cultured for E. coli and isolates subsequently virulotyped using 10 APEC virulence-associated genes (VAGs): astA, iss, irp2, iucD, papC, tsh, vat, cvi, sitA and ibeA. Approximately 70% of birds displayed signs of colibacillosis. Thirty distinct virulence profiles were identified among 157 E. coli. Isolates carried between zero and seven VAGs; ∼ 30% of E. coli isolates carried five to seven VAGs, with 12.7% sharing the same VAG profile (astA, iss, irp2, iucD, tsh, cvi and sitA). Overall, this study demonstrates the significant contribution of E. coli infections to early broiler mortalities. The identification of a diverse E. coli population is unsurprising based on our previous findings. This work emphasizes the need for an effective vaccination programme and provides preliminary data for vaccine production. SN - 1465-3338 UR - https://www.unboundmedicine.com/medline/citation/24328462/The_contribution_of_systemic_Escherichia_coli_infection_to_the_early_mortalities_of_commercial_broiler_chickens_ L2 - http://www.tandfonline.com/doi/full/10.1080/03079457.2013.866213 DB - PRIME DP - Unbound Medicine ER -