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Relationship of semen hyperviscosity with IL-6, TNF-α, IL-10 and ROS production in seminal plasma of infertile patients with prostatitis and prostato-vesiculitis.
Andrologia. 2014 Dec; 46(10):1148-55.A

Abstract

Changes in levels of oxidative damage products in semen and their relationship to seminal fluid viscosity (SFV) have recently received increasing research interest. We analysed whether SFV was associated with ROS generation, levels of cytokines TNF-alpha (TNF-α), IL-6 and IL-10 and seminal leucocyte concentration, and whether ROS production was related to the extent of infections/inflammations at one (prostatitis) or two (prostato-vesiculitis) male accessory glands. We studied 169 infertile patients, with chronic bacterial prostatitis (PR, n = 74) and/or bilateral prostato-vesiculitis (PV, n = 95), as diagnosed by the ultrasound (US) criteria. Healthy fertile men (n = 42) served as controls. In the PV patient group, SFV, semen characteristics and ROS production had median values that were significantly higher than those found in PR patients and controls, although other sperm variables had values significantly lower than those found in PR patients or controls. In PV infertile patients, ROS generation and pro-inflammatory cytokines levels were higher than those found in PR infertile patients and controls, although seminal IL-10 levels in PV and PR patients were lower than those found in the controls. In PR patients, the levels of SFV were positively related to TNF-α (r = 0.67; P < 0.01), fMLP-stimulated ROS production in the 45% Percoll fraction (r = 0.687, P < 0.01) and the 90% Percoll fraction in basal condition (r = 0.695, P < 0.01), and after fMLP-stimulation (r = 0.688, P < 0.01). Thus, our data indicated that seminal hyperviscosity is associated with increased oxidative stress in infertile men and increased pro-inflammatory interleukins in patients with male accessory gland infection, more when the infection was extended to the seminal vesicles.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Castiglione R
Section of Endocrinology and Andrology, Department of Medical and Pediatric Science, International Master in Experimental and Clinical Medicine and Cellular Physiopathology, University of Catania, Catania, Italy.
Salemi M
No affiliation info available
Vicari LO
No affiliation info available
Vicari E
No affiliation info available

MeSH

AdultHumansInfertility, MaleInterleukin-10Interleukin-6LeukocytesMaleOxidative StressProstatitisReactive Oxygen SpeciesSemenSeminal VesiclesSperm CountTumor Necrosis Factor-alphaViscosity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24329571

Citation

Castiglione, R, et al. "Relationship of Semen Hyperviscosity With IL-6, TNF-α, IL-10 and ROS Production in Seminal Plasma of Infertile Patients With Prostatitis and Prostato-vesiculitis." Andrologia, vol. 46, no. 10, 2014, pp. 1148-55.
Castiglione R, Salemi M, Vicari LO, et al. Relationship of semen hyperviscosity with IL-6, TNF-α, IL-10 and ROS production in seminal plasma of infertile patients with prostatitis and prostato-vesiculitis. Andrologia. 2014;46(10):1148-55.
Castiglione, R., Salemi, M., Vicari, L. O., & Vicari, E. (2014). Relationship of semen hyperviscosity with IL-6, TNF-α, IL-10 and ROS production in seminal plasma of infertile patients with prostatitis and prostato-vesiculitis. Andrologia, 46(10), 1148-55. https://doi.org/10.1111/and.12207
Castiglione R, et al. Relationship of Semen Hyperviscosity With IL-6, TNF-α, IL-10 and ROS Production in Seminal Plasma of Infertile Patients With Prostatitis and Prostato-vesiculitis. Andrologia. 2014;46(10):1148-55. PubMed PMID: 24329571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of semen hyperviscosity with IL-6, TNF-α, IL-10 and ROS production in seminal plasma of infertile patients with prostatitis and prostato-vesiculitis. AU - Castiglione,R, AU - Salemi,M, AU - Vicari,L O, AU - Vicari,E, Y1 - 2013/12/16/ PY - 2013/10/21/accepted PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2015/6/30/medline KW - Infections KW - prostatitis KW - reactive oxygen species KW - semen cytokine KW - semen hyperviscosity SP - 1148 EP - 55 JF - Andrologia JO - Andrologia VL - 46 IS - 10 N2 - Changes in levels of oxidative damage products in semen and their relationship to seminal fluid viscosity (SFV) have recently received increasing research interest. We analysed whether SFV was associated with ROS generation, levels of cytokines TNF-alpha (TNF-α), IL-6 and IL-10 and seminal leucocyte concentration, and whether ROS production was related to the extent of infections/inflammations at one (prostatitis) or two (prostato-vesiculitis) male accessory glands. We studied 169 infertile patients, with chronic bacterial prostatitis (PR, n = 74) and/or bilateral prostato-vesiculitis (PV, n = 95), as diagnosed by the ultrasound (US) criteria. Healthy fertile men (n = 42) served as controls. In the PV patient group, SFV, semen characteristics and ROS production had median values that were significantly higher than those found in PR patients and controls, although other sperm variables had values significantly lower than those found in PR patients or controls. In PV infertile patients, ROS generation and pro-inflammatory cytokines levels were higher than those found in PR infertile patients and controls, although seminal IL-10 levels in PV and PR patients were lower than those found in the controls. In PR patients, the levels of SFV were positively related to TNF-α (r = 0.67; P < 0.01), fMLP-stimulated ROS production in the 45% Percoll fraction (r = 0.687, P < 0.01) and the 90% Percoll fraction in basal condition (r = 0.695, P < 0.01), and after fMLP-stimulation (r = 0.688, P < 0.01). Thus, our data indicated that seminal hyperviscosity is associated with increased oxidative stress in infertile men and increased pro-inflammatory interleukins in patients with male accessory gland infection, more when the infection was extended to the seminal vesicles. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/24329571/Relationship_of_semen_hyperviscosity_with_IL_6_TNF_α_IL_10_and_ROS_production_in_seminal_plasma_of_infertile_patients_with_prostatitis_and_prostato_vesiculitis_ DB - PRIME DP - Unbound Medicine ER -