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Juvenile idiopathic arthritis-associated uveitis at an Italian tertiary referral center: clinical features and complications.
Ocul Immunol Inflamm. 2015 Feb; 23(1):74-81.OI

Abstract

PURPOSE

To describe the frequencies and risk factors of ocular complications and poor visual outcomes in children with juvenile idiopathic arthritis (JIA).

METHODS

Retrospective cohort study, including 69 consecutive children (116 eyes) affected by JIA-associated uveitis managed at a tertiary uveitis clinic.

RESULTS

The incidence of visual loss to the 20/50 or worse threshold was 0.04/eye-year (EY) and to the 20/200 or worse threshold was 0.02/EY. The most common complications at baseline were posterior synechiae (52%), band keratopathy (38%), and cataract (12%). Risk factor for a visual acuity threshold of 20/50 or worse included hypotony (p = 0.01; hazard ratio [HR] 3.7; 95% CI 1.3-10.4); anterior chamber flare >1 (p = 0.04; HR 1.3; 95% CI 0.5-3.4); a positive antinuclear antibody (ANA) (p = 0.02; HR1.4; 95% CI 0.8-2.4). Hypotony and positive ANA are also associated to the 20/200 or worse threshold (p = 0.03; HR 5.1; 95% CI 1.1-23.9 and p = 0.04; HR 1.0; 95% CI 0.4-2.3; respectively). Use of immunosuppressive drugs was associated with a reduced risk of visual loss of 20/200 or worse (odds ratio 0.14, 95% CI, 0.02-1.29; p = 0.04).

CONCLUSIONS

Loss of vision and ocular complications still occur among children with JIA-related uveitis. Prompt diagnosis and a strict follow up associated to immunosuppressive therapy may decrease the poor visual outcome.

Authors+Show Affiliations

Ocular Immunovirology Service, University of Rome , Sapienza , Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24329729

Citation

Paroli, Maria Pia, et al. "Juvenile Idiopathic Arthritis-associated Uveitis at an Italian Tertiary Referral Center: Clinical Features and Complications." Ocular Immunology and Inflammation, vol. 23, no. 1, 2015, pp. 74-81.
Paroli MP, Abbouda A, Restivo L, et al. Juvenile idiopathic arthritis-associated uveitis at an Italian tertiary referral center: clinical features and complications. Ocul Immunol Inflamm. 2015;23(1):74-81.
Paroli, M. P., Abbouda, A., Restivo, L., Sapia, A., Abicca, I., & Pivetti Pezzi, P. (2015). Juvenile idiopathic arthritis-associated uveitis at an Italian tertiary referral center: clinical features and complications. Ocular Immunology and Inflammation, 23(1), 74-81. https://doi.org/10.3109/09273948.2013.855798
Paroli MP, et al. Juvenile Idiopathic Arthritis-associated Uveitis at an Italian Tertiary Referral Center: Clinical Features and Complications. Ocul Immunol Inflamm. 2015;23(1):74-81. PubMed PMID: 24329729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Juvenile idiopathic arthritis-associated uveitis at an Italian tertiary referral center: clinical features and complications. AU - Paroli,Maria Pia, AU - Abbouda,Alessandro, AU - Restivo,Lucia, AU - Sapia,Alfredo, AU - Abicca,Irene, AU - Pivetti Pezzi,Paola, Y1 - 2013/12/11/ PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2015/11/18/medline KW - Children; juvenile idiopathic arthritis KW - ocular complication KW - uveitis KW - visual acuity SP - 74 EP - 81 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 23 IS - 1 N2 - PURPOSE: To describe the frequencies and risk factors of ocular complications and poor visual outcomes in children with juvenile idiopathic arthritis (JIA). METHODS: Retrospective cohort study, including 69 consecutive children (116 eyes) affected by JIA-associated uveitis managed at a tertiary uveitis clinic. RESULTS: The incidence of visual loss to the 20/50 or worse threshold was 0.04/eye-year (EY) and to the 20/200 or worse threshold was 0.02/EY. The most common complications at baseline were posterior synechiae (52%), band keratopathy (38%), and cataract (12%). Risk factor for a visual acuity threshold of 20/50 or worse included hypotony (p = 0.01; hazard ratio [HR] 3.7; 95% CI 1.3-10.4); anterior chamber flare >1 (p = 0.04; HR 1.3; 95% CI 0.5-3.4); a positive antinuclear antibody (ANA) (p = 0.02; HR1.4; 95% CI 0.8-2.4). Hypotony and positive ANA are also associated to the 20/200 or worse threshold (p = 0.03; HR 5.1; 95% CI 1.1-23.9 and p = 0.04; HR 1.0; 95% CI 0.4-2.3; respectively). Use of immunosuppressive drugs was associated with a reduced risk of visual loss of 20/200 or worse (odds ratio 0.14, 95% CI, 0.02-1.29; p = 0.04). CONCLUSIONS: Loss of vision and ocular complications still occur among children with JIA-related uveitis. Prompt diagnosis and a strict follow up associated to immunosuppressive therapy may decrease the poor visual outcome. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/24329729/Juvenile_idiopathic_arthritis_associated_uveitis_at_an_Italian_tertiary_referral_center:_clinical_features_and_complications_ DB - PRIME DP - Unbound Medicine ER -