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Whole-body fluid distribution in humans during dehydration and recovery, before and after humid-heat acclimation induced using controlled hyperthermia.
Acta Physiol (Oxf). 2014 Apr; 210(4):899-912.AP

Abstract

AIM

This experiment was designed to test the hypothesis that the plasma volume is not selectively defended during exercise- and heat-induced dehydration following humid-heat acclimation.

METHODS

Eight physically active males were heat acclimated (39.8 °C, relative humidity 59.2%) using 17 days of controlled hyperthermia (core temperature: 38.5 °C). Inter-compartmental fluid losses and movements were tracked (radioisotopes and Evans blue dye) during progressive dehydration (cycling) in these same conditions and also during a resting recovery without fluid replacement (28 °C), before (day 1), during (day 8) and after heat acclimation (day 22).

RESULTS

On days 8 and 22, there were significant increases in total body water, interstitial fluid and plasma volume (P < 0.05), but the intracellular compartments did not change (P > 0.05). The baseline plasma volume remained expanded throughout: 43.4 [±2.6 (day 1)], 49.1 [±2.4 (day 8); P < 0.05] and 48.9 mL kg(-1) [±3.0 (day 22); P < 0.05]. During progressive dehydration, plasma reductions of 9.0% (±0.9: day 1), 12.4% (±1.6: day 8) and 13.6% (±1.2: day 22) were observed, with day 8 and 22 losses significantly exceeding day 1 (P < 0.05). During recovery, plasma volume restoration commenced, with the intracellular fluid contribution becoming more pronounced as acclimation progressed.

CONCLUSION

It is concluded that the plasma volume was not defended more vigorously following humid-heat acclimation. Indeed, a greater fluid loss may well underlie the mechanisms for enhancing plasma volume recovery when heat acclimation is induced using the controlled-hyperthermia technique.

Authors+Show Affiliations

Centre for Human and Applied Physiology, School of Medicine, University of Wollongong, Wollongong, NSW, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24330400

Citation

Patterson, M J., et al. "Whole-body Fluid Distribution in Humans During Dehydration and Recovery, Before and After Humid-heat Acclimation Induced Using Controlled Hyperthermia." Acta Physiologica (Oxford, England), vol. 210, no. 4, 2014, pp. 899-912.
Patterson MJ, Stocks JM, Taylor NA. Whole-body fluid distribution in humans during dehydration and recovery, before and after humid-heat acclimation induced using controlled hyperthermia. Acta Physiol (Oxf). 2014;210(4):899-912.
Patterson, M. J., Stocks, J. M., & Taylor, N. A. (2014). Whole-body fluid distribution in humans during dehydration and recovery, before and after humid-heat acclimation induced using controlled hyperthermia. Acta Physiologica (Oxford, England), 210(4), 899-912. https://doi.org/10.1111/apha.12214
Patterson MJ, Stocks JM, Taylor NA. Whole-body Fluid Distribution in Humans During Dehydration and Recovery, Before and After Humid-heat Acclimation Induced Using Controlled Hyperthermia. Acta Physiol (Oxf). 2014;210(4):899-912. PubMed PMID: 24330400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Whole-body fluid distribution in humans during dehydration and recovery, before and after humid-heat acclimation induced using controlled hyperthermia. AU - Patterson,M J, AU - Stocks,J M, AU - Taylor,N A S, Y1 - 2014/01/16/ PY - 2013/08/22/received PY - 2013/10/21/revised PY - 2013/11/30/revised PY - 2013/12/09/accepted PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/11/11/medline KW - body fluids KW - extracellular fluid KW - heat acclimation KW - plasma volume SP - 899 EP - 912 JF - Acta physiologica (Oxford, England) JO - Acta Physiol (Oxf) VL - 210 IS - 4 N2 - AIM: This experiment was designed to test the hypothesis that the plasma volume is not selectively defended during exercise- and heat-induced dehydration following humid-heat acclimation. METHODS: Eight physically active males were heat acclimated (39.8 °C, relative humidity 59.2%) using 17 days of controlled hyperthermia (core temperature: 38.5 °C). Inter-compartmental fluid losses and movements were tracked (radioisotopes and Evans blue dye) during progressive dehydration (cycling) in these same conditions and also during a resting recovery without fluid replacement (28 °C), before (day 1), during (day 8) and after heat acclimation (day 22). RESULTS: On days 8 and 22, there were significant increases in total body water, interstitial fluid and plasma volume (P < 0.05), but the intracellular compartments did not change (P > 0.05). The baseline plasma volume remained expanded throughout: 43.4 [±2.6 (day 1)], 49.1 [±2.4 (day 8); P < 0.05] and 48.9 mL kg(-1) [±3.0 (day 22); P < 0.05]. During progressive dehydration, plasma reductions of 9.0% (±0.9: day 1), 12.4% (±1.6: day 8) and 13.6% (±1.2: day 22) were observed, with day 8 and 22 losses significantly exceeding day 1 (P < 0.05). During recovery, plasma volume restoration commenced, with the intracellular fluid contribution becoming more pronounced as acclimation progressed. CONCLUSION: It is concluded that the plasma volume was not defended more vigorously following humid-heat acclimation. Indeed, a greater fluid loss may well underlie the mechanisms for enhancing plasma volume recovery when heat acclimation is induced using the controlled-hyperthermia technique. SN - 1748-1716 UR - https://www.unboundmedicine.com/medline/citation/24330400/Whole_body_fluid_distribution_in_humans_during_dehydration_and_recovery_before_and_after_humid_heat_acclimation_induced_using_controlled_hyperthermia_ L2 - https://doi.org/10.1111/apha.12214 DB - PRIME DP - Unbound Medicine ER -