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Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study.
Nutr J. 2013 Dec 13; 12:161.NJ

Abstract

BACKGROUND

Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms.

METHODS

The study was a randomized, double-blind, placebo-controlled, parallel intervention. Subjects drank a low calorie cranberry beverage (450 ml) made with a juice-derived, powdered cranberry fraction (n = 22) or a placebo beverage (n = 23), daily, for 10 wk. PBMC were cultured for six days with autologous serum and PHA-L stimulation. Cold and influenza symptoms were self-reported.

RESULTS

The proliferation index of γδ-T cells in culture was almost five times higher after 10 wk of cranberry beverage consumption (p <0.001). In the cranberry beverage group, the incidence of illness was not reduced, however significantly fewer symptoms of illness were reported (p = 0.031).

CONCLUSIONS

Consumption of the cranberry beverage modified the ex vivo proliferation of γδ-T cells. As these cells are located in the epithelium and serve as a first line of defense, improving their function may be related to reducing the number of symptoms associated with a cold and flu.

Links

PMC Free PDF

Authors+Show Affiliations

Nantz MP
No affiliation info available
Rowe CA
No affiliation info available
Muller C
No affiliation info available
Creasy R
No affiliation info available
Colee J
No affiliation info available
Khoo C
No affiliation info available
Percival SS
Department of Food Science & Human Nutrition, University of Florida, Box 110370, Gainesville, FL 32611, USA. percival@ufl.edu.

MeSH

AdultBeveragesCell ProliferationCells, CulturedCommon ColdCytokinesDouble-Blind MethodFemaleFloridaFruitFunctional FoodHumansImmunomodulationIncidenceInfluenza, HumanLeukocytes, MononuclearMaleNon-Nutritive SweetenersPolyphenolsProanthocyanidinsSeverity of Illness IndexVaccinium macrocarpon

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24330619

Clinical Trial Links

Clinical trial which this article describes

Citation

Nantz, Meri P., et al. "Consumption of Cranberry Polyphenols Enhances Human γδ-T Cell Proliferation and Reduces the Number of Symptoms Associated With Colds and Influenza: a Randomized, Placebo-controlled Intervention Study." Nutrition Journal, vol. 12, 2013, p. 161.
Nantz MP, Rowe CA, Muller C, et al. Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study. Nutr J. 2013;12:161.
Nantz, M. P., Rowe, C. A., Muller, C., Creasy, R., Colee, J., Khoo, C., & Percival, S. S. (2013). Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study. Nutrition Journal, 12, 161. https://doi.org/10.1186/1475-2891-12-161
Nantz MP, et al. Consumption of Cranberry Polyphenols Enhances Human γδ-T Cell Proliferation and Reduces the Number of Symptoms Associated With Colds and Influenza: a Randomized, Placebo-controlled Intervention Study. Nutr J. 2013 Dec 13;12:161. PubMed PMID: 24330619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study. AU - Nantz,Meri P, AU - Rowe,Cheryl A, AU - Muller,Catherine, AU - Creasy,Rebecca, AU - Colee,James, AU - Khoo,Christina, AU - Percival,Susan S, Y1 - 2013/12/13/ PY - 2013/09/25/received PY - 2013/12/09/accepted PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/7/23/medline SP - 161 EP - 161 JF - Nutrition journal JO - Nutr J VL - 12 N2 - BACKGROUND: Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms. METHODS: The study was a randomized, double-blind, placebo-controlled, parallel intervention. Subjects drank a low calorie cranberry beverage (450 ml) made with a juice-derived, powdered cranberry fraction (n = 22) or a placebo beverage (n = 23), daily, for 10 wk. PBMC were cultured for six days with autologous serum and PHA-L stimulation. Cold and influenza symptoms were self-reported. RESULTS: The proliferation index of γδ-T cells in culture was almost five times higher after 10 wk of cranberry beverage consumption (p <0.001). In the cranberry beverage group, the incidence of illness was not reduced, however significantly fewer symptoms of illness were reported (p = 0.031). CONCLUSIONS: Consumption of the cranberry beverage modified the ex vivo proliferation of γδ-T cells. As these cells are located in the epithelium and serve as a first line of defense, improving their function may be related to reducing the number of symptoms associated with a cold and flu. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/24330619/Consumption_of_cranberry_polyphenols_enhances_human_γδ_T_cell_proliferation_and_reduces_the_number_of_symptoms_associated_with_colds_and_influenza:_a_randomized_placebo_controlled_intervention_study_ DB - PRIME DP - Unbound Medicine ER -
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