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Antibacterial activity of the roots, stems and leaves of Alchornea floribunda.
J Ethnopharmacol. 2014 Feb 03; 151(2):1023-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Alchornea floribunda Müll. Arg. is used in traditional medicine across Africa for the treatment of bacterial, fungal, parasitic and inflammatory disorders.

AIM OF THE STUDY

To evaluate the antibacterial activity of the crude extracts of different plant parts in order to provide a scientific rationale for the proposed broad efficacy of Alchornea floribunda in the treatment of bacterial infections.

MATERIALS AND METHODS

Extracts of roots, stems and leaves were prepared using solvents of various polarities in order to extract a wide range of phytochemicals. The antibacterial activity of these crude extracts was evaluated by micro-dilution assay, against Gram-positive (i.e. Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus and Staphylococcus saprophyticus) as well as Gram-negative (i.e. Escherichia coli, Klebsiella pneumoniae, Moraxella catarrhalis and Proteus mirabilis) bacteria.

RESULTS

Generally, the ethanol (EtOH), methanol (MeOH), ethyl acetate (EtOAc) and chloroform (CHCl3) extracts demonstrated the best activities, with the leaves exhibiting the highest average activity for six of the eight pathogens. Of these, the ethanolic leaf extract was the most active against Staphylococcus aureus with an MIC value of 50µg/mL. Some other notable activity was observed for the ethyl acetate and chloroform root extracts against Staphylococcus aureus (50µg/mL), and for selected stem extracts against Staphylococcus aureus (50µg/mL), Klebsiella pneumoniae (63µg/mL) and Staphylococcus saprophyticus (63µg/mL).

CONCLUSION

This study demonstrates the promising antibacterial activity of Alchornea floribunda against both Gram-positive and Gram-negative bacteria responsible for gastrointestinal, skin, respiratory and urinary ailments, and validates its use in the ethnopharmacology of the region.

Authors+Show Affiliations

Department of Applied Chemistry, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa. Electronic address: r.krause@ru.ac.za.Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa.Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa.School of Mining, Metallurgy and Chemical Engineering, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24333961

Citation

Siwe Noundou, X, et al. "Antibacterial Activity of the Roots, Stems and Leaves of Alchornea Floribunda." Journal of Ethnopharmacology, vol. 151, no. 2, 2014, pp. 1023-7.
Siwe Noundou X, Krause RW, van Vuuren SF, et al. Antibacterial activity of the roots, stems and leaves of Alchornea floribunda. J Ethnopharmacol. 2014;151(2):1023-7.
Siwe Noundou, X., Krause, R. W., van Vuuren, S. F., Tantoh Ndinteh, D., & Olivier, D. K. (2014). Antibacterial activity of the roots, stems and leaves of Alchornea floribunda. Journal of Ethnopharmacology, 151(2), 1023-7. https://doi.org/10.1016/j.jep.2013.12.002
Siwe Noundou X, et al. Antibacterial Activity of the Roots, Stems and Leaves of Alchornea Floribunda. J Ethnopharmacol. 2014 Feb 3;151(2):1023-7. PubMed PMID: 24333961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial activity of the roots, stems and leaves of Alchornea floribunda. AU - Siwe Noundou,X, AU - Krause,R W M, AU - van Vuuren,S F, AU - Tantoh Ndinteh,D, AU - Olivier,D K, Y1 - 2013/12/11/ PY - 2013/02/11/received PY - 2013/08/14/revised PY - 2013/12/03/accepted PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/9/18/medline KW - ATCC KW - Alchornea floribunda KW - American type culture collection KW - Antibacterial activity KW - CFU/ml KW - CHCl(3) KW - DMSO KW - EtOAc KW - EtOH KW - Euphorbiaceae KW - HNC KW - Herbier National du Cameroun KW - INT KW - IZD KW - MIC KW - MeOH KW - chloroform extract KW - colony forming units/ml KW - dimethyl sulfoxide KW - ethanol extract KW - ethyl acetate extract KW - inhibition zone diameter KW - iodonitrotetrazolium chloride KW - methanol extract KW - minimum inhibitory concentration KW - w/v KW - weight by volume SP - 1023 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 151 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Alchornea floribunda Müll. Arg. is used in traditional medicine across Africa for the treatment of bacterial, fungal, parasitic and inflammatory disorders. AIM OF THE STUDY: To evaluate the antibacterial activity of the crude extracts of different plant parts in order to provide a scientific rationale for the proposed broad efficacy of Alchornea floribunda in the treatment of bacterial infections. MATERIALS AND METHODS: Extracts of roots, stems and leaves were prepared using solvents of various polarities in order to extract a wide range of phytochemicals. The antibacterial activity of these crude extracts was evaluated by micro-dilution assay, against Gram-positive (i.e. Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus and Staphylococcus saprophyticus) as well as Gram-negative (i.e. Escherichia coli, Klebsiella pneumoniae, Moraxella catarrhalis and Proteus mirabilis) bacteria. RESULTS: Generally, the ethanol (EtOH), methanol (MeOH), ethyl acetate (EtOAc) and chloroform (CHCl3) extracts demonstrated the best activities, with the leaves exhibiting the highest average activity for six of the eight pathogens. Of these, the ethanolic leaf extract was the most active against Staphylococcus aureus with an MIC value of 50µg/mL. Some other notable activity was observed for the ethyl acetate and chloroform root extracts against Staphylococcus aureus (50µg/mL), and for selected stem extracts against Staphylococcus aureus (50µg/mL), Klebsiella pneumoniae (63µg/mL) and Staphylococcus saprophyticus (63µg/mL). CONCLUSION: This study demonstrates the promising antibacterial activity of Alchornea floribunda against both Gram-positive and Gram-negative bacteria responsible for gastrointestinal, skin, respiratory and urinary ailments, and validates its use in the ethnopharmacology of the region. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/24333961/Antibacterial_activity_of_the_roots_stems_and_leaves_of_Alchornea_floribunda_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00865-9 DB - PRIME DP - Unbound Medicine ER -