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In vitro susceptibility of Malassezia pachydermatis isolates from canine skin with atopic dermatitis to ketoconazole and itraconazole in East Asia.
J Vet Med Sci. 2014 Apr; 76(4):579-81.JV

Abstract

Topical or oral azole antifungals are commonly used in canine atopic dermatitis (AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canine AD. To examine whether canine AD lesions harbor azole-resistant M. pachydermatis isolates in East Asia, we investigated the in vitro susceptibility of M. pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan, Korea and Taiwan. The minimum inhibitory concentrations (MICs) of KTZ and ITZ were measured by the E-test using Sabouraud dextrose agar with 0.5% Tween 40. The MICs of KTZ and ITZ for isolates from canines with AD were significantly higher than the MICs for isolates from healthy canines. Our findings suggested that the clinical isolates from canine AD skin lesions were less susceptible to azoles than those from normal canine skin in East Asia.

Authors+Show Affiliations

Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24334863

Citation

Watanabe, Shion, et al. "In Vitro Susceptibility of Malassezia Pachydermatis Isolates From Canine Skin With Atopic Dermatitis to Ketoconazole and Itraconazole in East Asia." The Journal of Veterinary Medical Science, vol. 76, no. 4, 2014, pp. 579-81.
Watanabe S, Koike A, Kano R, et al. In vitro susceptibility of Malassezia pachydermatis isolates from canine skin with atopic dermatitis to ketoconazole and itraconazole in East Asia. J Vet Med Sci. 2014;76(4):579-81.
Watanabe, S., Koike, A., Kano, R., Nagata, M., Chen, C., Hwang, C. Y., Hasegawa, A., & Kamata, H. (2014). In vitro susceptibility of Malassezia pachydermatis isolates from canine skin with atopic dermatitis to ketoconazole and itraconazole in East Asia. The Journal of Veterinary Medical Science, 76(4), 579-81.
Watanabe S, et al. In Vitro Susceptibility of Malassezia Pachydermatis Isolates From Canine Skin With Atopic Dermatitis to Ketoconazole and Itraconazole in East Asia. J Vet Med Sci. 2014;76(4):579-81. PubMed PMID: 24334863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro susceptibility of Malassezia pachydermatis isolates from canine skin with atopic dermatitis to ketoconazole and itraconazole in East Asia. AU - Watanabe,Shion, AU - Koike,Anna, AU - Kano,Rui, AU - Nagata,Masahiko, AU - Chen,Charles, AU - Hwang,Cheol-Yong, AU - Hasegawa,Atsuhiko, AU - Kamata,Hiroshi, Y1 - 2013/12/13/ PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/12/30/medline SP - 579 EP - 81 JF - The Journal of veterinary medical science JO - J. Vet. Med. Sci. VL - 76 IS - 4 N2 - Topical or oral azole antifungals are commonly used in canine atopic dermatitis (AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canine AD. To examine whether canine AD lesions harbor azole-resistant M. pachydermatis isolates in East Asia, we investigated the in vitro susceptibility of M. pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan, Korea and Taiwan. The minimum inhibitory concentrations (MICs) of KTZ and ITZ were measured by the E-test using Sabouraud dextrose agar with 0.5% Tween 40. The MICs of KTZ and ITZ for isolates from canines with AD were significantly higher than the MICs for isolates from healthy canines. Our findings suggested that the clinical isolates from canine AD skin lesions were less susceptible to azoles than those from normal canine skin in East Asia. SN - 1347-7439 UR - https://www.unboundmedicine.com/medline/citation/24334863/In_vitro_susceptibility_of_Malassezia_pachydermatis_isolates_from_canine_skin_with_atopic_dermatitis_to_ketoconazole_and_itraconazole_in_East_Asia_ L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/jvms/13-0433?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -