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Serum hepcidin is associated with presence of plaque in postmenopausal women of a general population.
Arterioscler Thromb Vasc Biol 2014; 34(2):446-56AT

Abstract

OBJECTIVE

Iron and the iron regulatory hormone hepcidin, major determinant of body iron distribution, are hypothesized to play a role in cardiovascular disease. Here, we assess the associations of hepcidin as well as ferritin, iron, total iron-binding capacity, and transferrin saturation (ie, iron parameters) with noninvasive measurements of atherosclerosis in men and women of a population-based cohort.

APPROACH AND RESULTS

We included 766 participants of the Nijmegen Biomedical Study aged 46 to 67 years for whom serum measurements of hepcidin, iron parameters, and noninvasive measurements of atherosclerosis were available. Noninvasive measurements of atherosclerosis were presence of plaque, ankle-brachial index, and intima-media thickness. We performed multivariable logistic and linear regression analyses using quartiles of hepcidin and iron parameters. Analyses were stratified by sex and adjusted for several demographic, clinical, and biochemical determinants, including traditional risk factors of cardiovascular disease based on the Framingham risk score. Hepcidin and the hepcidin/ferritin ratio, reflecting hepcidin expression relative to iron stores, were significantly associated with the presence of plaque in women (adjusted odds ratios for quartile 4 versus quartile 1 [95% confidence intervals] of 3.07 [1.36-6.90] and 2.31 [1.03-5.18], respectively). The hepcidin/ferritin ratio was significantly and negatively associated with ankle-brachial index at rest in men and women (adjusted β for quartile 4 versus quartile 1 [95% confidence intervals] of -0.03 [-0.07 to 0.00] and -0.04 [-0.06 to -0.01], respectively).

CONCLUSIONS

Our results suggest that the body iron distribution as determined by hepcidin affects the development of atherosclerosis in women.

Authors+Show Affiliations

From the Department for Health Evidence (T.E.G., L.A.L.M.K., S.H.V.), Department of General Internal Medicine, Division of Vascular Medicine (S.H., J.d.G.), Department of Urology (L.A.L.M.K.), and Laboratory of Genetic, Endocrine and Metabolic Diseases, Department of Laboratory Medicine (D.W.S.), Radboud University Medical Center, Nijmegen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24334869

Citation

Galesloot, Tessel E., et al. "Serum Hepcidin Is Associated With Presence of Plaque in Postmenopausal Women of a General Population." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 2, 2014, pp. 446-56.
Galesloot TE, Holewijn S, Kiemeney LA, et al. Serum hepcidin is associated with presence of plaque in postmenopausal women of a general population. Arterioscler Thromb Vasc Biol. 2014;34(2):446-56.
Galesloot, T. E., Holewijn, S., Kiemeney, L. A., de Graaf, J., Vermeulen, S. H., & Swinkels, D. W. (2014). Serum hepcidin is associated with presence of plaque in postmenopausal women of a general population. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(2), pp. 446-56. doi:10.1161/ATVBAHA.113.302381.
Galesloot TE, et al. Serum Hepcidin Is Associated With Presence of Plaque in Postmenopausal Women of a General Population. Arterioscler Thromb Vasc Biol. 2014;34(2):446-56. PubMed PMID: 24334869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum hepcidin is associated with presence of plaque in postmenopausal women of a general population. AU - Galesloot,Tessel E, AU - Holewijn,Suzanne, AU - Kiemeney,Lambertus A L M, AU - de Graaf,Jacqueline, AU - Vermeulen,Sita H, AU - Swinkels,Dorine W, Y1 - 2013/12/12/ PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/3/22/medline KW - atherosclerosis KW - cardiovascular disease KW - hepcidin KW - iron SP - 446 EP - 56 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 34 IS - 2 N2 - OBJECTIVE: Iron and the iron regulatory hormone hepcidin, major determinant of body iron distribution, are hypothesized to play a role in cardiovascular disease. Here, we assess the associations of hepcidin as well as ferritin, iron, total iron-binding capacity, and transferrin saturation (ie, iron parameters) with noninvasive measurements of atherosclerosis in men and women of a population-based cohort. APPROACH AND RESULTS: We included 766 participants of the Nijmegen Biomedical Study aged 46 to 67 years for whom serum measurements of hepcidin, iron parameters, and noninvasive measurements of atherosclerosis were available. Noninvasive measurements of atherosclerosis were presence of plaque, ankle-brachial index, and intima-media thickness. We performed multivariable logistic and linear regression analyses using quartiles of hepcidin and iron parameters. Analyses were stratified by sex and adjusted for several demographic, clinical, and biochemical determinants, including traditional risk factors of cardiovascular disease based on the Framingham risk score. Hepcidin and the hepcidin/ferritin ratio, reflecting hepcidin expression relative to iron stores, were significantly associated with the presence of plaque in women (adjusted odds ratios for quartile 4 versus quartile 1 [95% confidence intervals] of 3.07 [1.36-6.90] and 2.31 [1.03-5.18], respectively). The hepcidin/ferritin ratio was significantly and negatively associated with ankle-brachial index at rest in men and women (adjusted β for quartile 4 versus quartile 1 [95% confidence intervals] of -0.03 [-0.07 to 0.00] and -0.04 [-0.06 to -0.01], respectively). CONCLUSIONS: Our results suggest that the body iron distribution as determined by hepcidin affects the development of atherosclerosis in women. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/24334869/Serum_hepcidin_is_associated_with_presence_of_plaque_in_postmenopausal_women_of_a_general_population_ L2 - http://www.ahajournals.org/doi/full/10.1161/ATVBAHA.113.302381?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -