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Association between serum vitamin D status and functional mobility in memory clinic patients aged 65 years and older.

Abstract

BACKGROUND

Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population. This association may be of particular interest to older people at risk for cognitive impairment and functional decline.

OBJECTIVE

The aim of this study was to determine the association between serum 25-hydroxyvitamin D [25(OH)D] status and functional mobility in seniors assessed in a memory clinic.

METHODS

We conducted a cross-sectional study of outpatients (n = 404) in a memory clinic. Functional mobility was assessed with three endpoints: normal and fast walking speed and the Timed Up and Go (TUG) test. Adjusted multivariate analyses in all patients and two pre-planned subgroup analyses in vulnerable seniors (previous fall and MMSE score of ≥26 or no previous fall and MMSE score of <26) versus less vulnerable seniors (no previous fall and MMSE score of ≥26) were performed to assess the association of 25(OH)D and functional mobility.

RESULTS

Overall, mean 25(OH)D serum levels were 63.2 ± 33.9 nmol/l, and 41.3% were vitamin D deficient (<50 nmol/l). Seniors in the lowest 25(OH)D quartile (<39 nmol/l) had significantly worse functional mobility compared to the highest 25(OH)D quartile (>81 nmol/l); adjusted for all covariates, seniors in the highest quartile performed 9.4% better in normal (p = 0.02) and 9.2% better in fast (p = 0.004) walking speed, and 4.4% better in the TUG test (p = 0.24). The association between 25(OH)D status and functional mobility was most pronounced in less vulnerable seniors (p for trend significant for all three mobility tests). Seniors with a higher 25(OH)D status also had better cognitive function (MMSE score; p = 0.006).

CONCLUSIONS

Lower serum 25(OH)D status is associated with poorer functional mobility and cognitive function, therefore supporting 25(OH)D assessment in this population at risk for both functional and cognitive decline.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Basel Mobility Center, Department of Acute Geriatrics, University Hospital Basel, Basel, Switzerland.

    , , ,

    Source

    Gerontology 60:2 2014 pg 123-9

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Cognition
    Cognition Disorders
    Cross-Sectional Studies
    Female
    Humans
    Male
    Memory
    Memory Disorders
    Mental Status Schedule
    Mobility Limitation
    Physical Fitness
    Risk Factors
    Vitamin D
    Walking

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24335110

    Citation

    Gschwind, Yves J., et al. "Association Between Serum Vitamin D Status and Functional Mobility in Memory Clinic Patients Aged 65 Years and Older." Gerontology, vol. 60, no. 2, 2014, pp. 123-9.
    Gschwind YJ, Bischoff-Ferrari HA, Bridenbaugh SA, et al. Association between serum vitamin D status and functional mobility in memory clinic patients aged 65 years and older. Gerontology. 2014;60(2):123-9.
    Gschwind, Y. J., Bischoff-Ferrari, H. A., Bridenbaugh, S. A., Härdi, I., & Kressig, R. W. (2014). Association between serum vitamin D status and functional mobility in memory clinic patients aged 65 years and older. Gerontology, 60(2), pp. 123-9. doi:10.1159/000355667.
    Gschwind YJ, et al. Association Between Serum Vitamin D Status and Functional Mobility in Memory Clinic Patients Aged 65 Years and Older. Gerontology. 2014;60(2):123-9. PubMed PMID: 24335110.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between serum vitamin D status and functional mobility in memory clinic patients aged 65 years and older. AU - Gschwind,Yves J, AU - Bischoff-Ferrari,Heike A, AU - Bridenbaugh,Stephanie A, AU - Härdi,Irene, AU - Kressig,Reto W, Y1 - 2013/12/07/ PY - 2013/06/19/received PY - 2013/09/10/accepted PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/10/21/medline SP - 123 EP - 9 JF - Gerontology JO - Gerontology VL - 60 IS - 2 N2 - BACKGROUND: Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population. This association may be of particular interest to older people at risk for cognitive impairment and functional decline. OBJECTIVE: The aim of this study was to determine the association between serum 25-hydroxyvitamin D [25(OH)D] status and functional mobility in seniors assessed in a memory clinic. METHODS: We conducted a cross-sectional study of outpatients (n = 404) in a memory clinic. Functional mobility was assessed with three endpoints: normal and fast walking speed and the Timed Up and Go (TUG) test. Adjusted multivariate analyses in all patients and two pre-planned subgroup analyses in vulnerable seniors (previous fall and MMSE score of ≥26 or no previous fall and MMSE score of <26) versus less vulnerable seniors (no previous fall and MMSE score of ≥26) were performed to assess the association of 25(OH)D and functional mobility. RESULTS: Overall, mean 25(OH)D serum levels were 63.2 ± 33.9 nmol/l, and 41.3% were vitamin D deficient (<50 nmol/l). Seniors in the lowest 25(OH)D quartile (<39 nmol/l) had significantly worse functional mobility compared to the highest 25(OH)D quartile (>81 nmol/l); adjusted for all covariates, seniors in the highest quartile performed 9.4% better in normal (p = 0.02) and 9.2% better in fast (p = 0.004) walking speed, and 4.4% better in the TUG test (p = 0.24). The association between 25(OH)D status and functional mobility was most pronounced in less vulnerable seniors (p for trend significant for all three mobility tests). Seniors with a higher 25(OH)D status also had better cognitive function (MMSE score; p = 0.006). CONCLUSIONS: Lower serum 25(OH)D status is associated with poorer functional mobility and cognitive function, therefore supporting 25(OH)D assessment in this population at risk for both functional and cognitive decline. SN - 1423-0003 UR - https://www.unboundmedicine.com/medline/citation/24335110/Association_between_serum_vitamin_D_status_and_functional_mobility_in_memory_clinic_patients_aged_65_years_and_older_ L2 - https://www.karger.com?DOI=10.1159/000355667 DB - PRIME DP - Unbound Medicine ER -