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When and how to perform genetic testing for inherited colorectal cancer syndromes.

Abstract

The 2013 NCCN Clinical Practice Guidelines in Oncology for Colorectal Cancer Screening address the evaluation and management of patients at risk of inherited susceptibility to colorectal cancer. These patients include the 2 broad categories of patients with familial adenomatous polyposis and its variants, and those with hereditary nonpolyposis colorectal cancer, or Lynch syndrome. This article provides a somewhat personal, yet hopefully evidence-based, approach to the questions of when to test individuals for inherited susceptibility, and how to do so. "When" can be taken to mean "under what circumstance" and "at what age"; this article attempts to speak to each sense of the term.

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  • Publisher Full Text
  • Authors+Show Affiliations

    From the Department of Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

    Source

    MeSH

    Adenoma
    Colorectal Neoplasms
    Colorectal Neoplasms, Hereditary Nonpolyposis
    Genetic Testing
    Germ-Line Mutation
    Humans
    Immunohistochemistry
    Microsatellite Instability
    Neoplastic Syndromes, Hereditary
    Time Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    24335689

    Citation

    Lynch, Patrick M.. "When and How to Perform Genetic Testing for Inherited Colorectal Cancer Syndromes." Journal of the National Comprehensive Cancer Network : JNCCN, vol. 11, no. 12, 2013, pp. 1577-83.
    Lynch PM. When and how to perform genetic testing for inherited colorectal cancer syndromes. J Natl Compr Canc Netw. 2013;11(12):1577-83.
    Lynch, P. M. (2013). When and how to perform genetic testing for inherited colorectal cancer syndromes. Journal of the National Comprehensive Cancer Network : JNCCN, 11(12), pp. 1577-83.
    Lynch PM. When and How to Perform Genetic Testing for Inherited Colorectal Cancer Syndromes. J Natl Compr Canc Netw. 2013 Dec 1;11(12):1577-83. PubMed PMID: 24335689.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - When and how to perform genetic testing for inherited colorectal cancer syndromes. A1 - Lynch,Patrick M, PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/8/15/medline SP - 1577 EP - 83 JF - Journal of the National Comprehensive Cancer Network : JNCCN JO - J Natl Compr Canc Netw VL - 11 IS - 12 N2 - The 2013 NCCN Clinical Practice Guidelines in Oncology for Colorectal Cancer Screening address the evaluation and management of patients at risk of inherited susceptibility to colorectal cancer. These patients include the 2 broad categories of patients with familial adenomatous polyposis and its variants, and those with hereditary nonpolyposis colorectal cancer, or Lynch syndrome. This article provides a somewhat personal, yet hopefully evidence-based, approach to the questions of when to test individuals for inherited susceptibility, and how to do so. "When" can be taken to mean "under what circumstance" and "at what age"; this article attempts to speak to each sense of the term. SN - 1540-1413 UR - https://www.unboundmedicine.com/medline/citation/24335689/When_and_how_to_perform_genetic_testing_for_inherited_colorectal_cancer_syndromes_ L2 - http://www.jnccn.org/cgi/pmidlookup?view=long&pmid=24335689 DB - PRIME DP - Unbound Medicine ER -