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Nonalcoholic fatty liver disease is associated with low HDL cholesterol and coronary angioplasty in patients with type 2 diabetes.
Med Sci Monit 2013; 19:1167-72MS

Abstract

BACKGROUND

There is evidence that nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. In this study we examined factors associated with the presence of NAFLD and the prevalence of macroangiopathy in patients with type 2 diabetes.

MATERIAL AND METHODS

Subjects were 101 consecutive patients with type 2 diabetes: 72 with NAFLD and 29 free of NAFLD. NAFLD was diagnosed by ultrasonography. Serum lipids were measured enzymatically and glycated hemoglobin HbA1c was measured by HPLC.

RESULTS

The mean age of patients was 53.1 ± 10.4 in the NAFLD group and 44.9 ± 10.9 years in patients without NAFLD (p<0.001). The mean duration of diabetes was 10 ± 6.3 years in patients with NAFLD and 15.1 ± 7.8 years in those without NAFLD (p<0.001). Mean values of glycated hemoglobin A1c were similar in both groups. Patients with NAFLD were characterized by a significantly higher prevalence of coronary angioplasty (20.8% vs. 0%, p=0.008). Overweight and obesity were observed in a higher percentage of patients with NAFLD (p<0.001). Patients with NAFLD were characterized by significantly higher values of alanine transaminase (p=0.033), and lower serum concentrations of HDL-cholesterol (p<0.001) and creatinine (p=0.034). Logistic regression analysis (p<0.001) revealed that NAFLD was positively associated with waist circumference above normal (women >80 cm, men >94 cm) (p=0.0083) and alanine transaminase activity (p=0.0164), and negatively with creatinine concentration (p=0.0226). In a second logistic regression model (p<0.001), waist circumference (p<0.007) and total cholesterol (p<0.008) were positive predictors, while HDL-C (p<0.003) was a negative predictor of NAFLD.

CONCLUSIONS

The results of the study suggest that NAFLD is associated with visceral obesity and low HDL-cholesterol in patients with type 2 diabetes.

Authors+Show Affiliations

Department of Metabolic Diseases, Medical College, Jagiellonian University, University Hospital, Kraków, Poland.Department of Metabolic Diseases, Medical College, Jagiellonian University, University Hospital, Kraków, Poland.Department of Metabolic Diseases, Medical College, Jagiellonian University, University Hospital, Kraków, Poland.Department of Metabolic Diseases, Medical College, Jagiellonian University, University Hospital, Kraków, Poland.Department of Metabolic Diseases, Medical College, Jagiellonian University, University Hospital, Kraków, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24336007

Citation

Trojak, Aleksandra, et al. "Nonalcoholic Fatty Liver Disease Is Associated With Low HDL Cholesterol and Coronary Angioplasty in Patients With Type 2 Diabetes." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 19, 2013, pp. 1167-72.
Trojak A, Waluś-Miarka M, Woźniakiewicz E, et al. Nonalcoholic fatty liver disease is associated with low HDL cholesterol and coronary angioplasty in patients with type 2 diabetes. Med Sci Monit. 2013;19:1167-72.
Trojak, A., Waluś-Miarka, M., Woźniakiewicz, E., Małecki, M. T., & Idzior-Waluś, B. (2013). Nonalcoholic fatty liver disease is associated with low HDL cholesterol and coronary angioplasty in patients with type 2 diabetes. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 19, pp. 1167-72. doi:10.12659/MSM.889649.
Trojak A, et al. Nonalcoholic Fatty Liver Disease Is Associated With Low HDL Cholesterol and Coronary Angioplasty in Patients With Type 2 Diabetes. Med Sci Monit. 2013 Dec 16;19:1167-72. PubMed PMID: 24336007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic fatty liver disease is associated with low HDL cholesterol and coronary angioplasty in patients with type 2 diabetes. AU - Trojak,Aleksandra, AU - Waluś-Miarka,Małgorzata, AU - Woźniakiewicz,Ewa, AU - Małecki,Maciej T, AU - Idzior-Waluś,Barbara, Y1 - 2013/12/16/ PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/8/5/medline SP - 1167 EP - 72 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 19 N2 - BACKGROUND: There is evidence that nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. In this study we examined factors associated with the presence of NAFLD and the prevalence of macroangiopathy in patients with type 2 diabetes. MATERIAL AND METHODS: Subjects were 101 consecutive patients with type 2 diabetes: 72 with NAFLD and 29 free of NAFLD. NAFLD was diagnosed by ultrasonography. Serum lipids were measured enzymatically and glycated hemoglobin HbA1c was measured by HPLC. RESULTS: The mean age of patients was 53.1 ± 10.4 in the NAFLD group and 44.9 ± 10.9 years in patients without NAFLD (p<0.001). The mean duration of diabetes was 10 ± 6.3 years in patients with NAFLD and 15.1 ± 7.8 years in those without NAFLD (p<0.001). Mean values of glycated hemoglobin A1c were similar in both groups. Patients with NAFLD were characterized by a significantly higher prevalence of coronary angioplasty (20.8% vs. 0%, p=0.008). Overweight and obesity were observed in a higher percentage of patients with NAFLD (p<0.001). Patients with NAFLD were characterized by significantly higher values of alanine transaminase (p=0.033), and lower serum concentrations of HDL-cholesterol (p<0.001) and creatinine (p=0.034). Logistic regression analysis (p<0.001) revealed that NAFLD was positively associated with waist circumference above normal (women >80 cm, men >94 cm) (p=0.0083) and alanine transaminase activity (p=0.0164), and negatively with creatinine concentration (p=0.0226). In a second logistic regression model (p<0.001), waist circumference (p<0.007) and total cholesterol (p<0.008) were positive predictors, while HDL-C (p<0.003) was a negative predictor of NAFLD. CONCLUSIONS: The results of the study suggest that NAFLD is associated with visceral obesity and low HDL-cholesterol in patients with type 2 diabetes. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/24336007/Nonalcoholic_fatty_liver_disease_is_associated_with_low_HDL_cholesterol_and_coronary_angioplasty_in_patients_with_type_2_diabetes_ L2 - https://www.medscimonit.com/download/index/idArt/889649 DB - PRIME DP - Unbound Medicine ER -