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Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice.
Neurol Sci. 2014 Jun; 35(6):815-21.NS

Abstract

Chemotherapy drugs treatment causes neuropathic pain, hyperalgesia and allodynia are common components of neuropathic pain, so effectively therapeutic strategy is required. In this study, we evaluated the antinociceptive effects of matrine on vincristine-induced neuropathic pain in mice. Vincristine (100 μg/kg i.p.) was administered once per day for 7 days (day 0-6) in mice. Matrine (15, 30, 60 mg/kg, i.p.) was repeated administration in early phase (day 0-6) or late phase (day 7-13). Hyperalgesia and allodynia were evaluated by withdrawal response using von Frey filaments, plantar and cold-plate on 7, 14 and 21 day. Injection of vincristine produced mechanical hyperalgesia and cold allodynia. Matrine was found to produce a protective role in both von Frey filaments and cold-plate test. The analysis of the effect supports the hypothesis that matrine is useful in therapy of vincristine-induced neuropathic pain. In conclusion, this study demonstrates that administration of matrine is associated with antinociceptive effect on mechanical and cold stimuli in a mice model of vincristine-induced neuropathy pain.

Authors+Show Affiliations

Department of Pharmacology, Ningxia Medical University, Yinchuan, Ningxia, 750004, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24337989

Citation

Linglu, Dun, et al. "Antinociceptive Effect of Matrine On Vincristine-induced Neuropathic Pain Model in Mice." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 35, no. 6, 2014, pp. 815-21.
Linglu D, Yuxiang L, Yaqiong X, et al. Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice. Neurol Sci. 2014;35(6):815-21.
Linglu, D., Yuxiang, L., Yaqiong, X., Ru, Z., Lin, M., Shaoju, J., Juan, D., Tao, S., & Jianqiang, Y. (2014). Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 35(6), 815-21. https://doi.org/10.1007/s10072-013-1603-6
Linglu D, et al. Antinociceptive Effect of Matrine On Vincristine-induced Neuropathic Pain Model in Mice. Neurol Sci. 2014;35(6):815-21. PubMed PMID: 24337989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice. AU - Linglu,Dun, AU - Yuxiang,Li, AU - Yaqiong,Xu, AU - Ru,Zhou, AU - Lin,Ma, AU - Shaoju,Jin, AU - Juan,Du, AU - Tao,Sun, AU - Jianqiang,Yu, Y1 - 2013/12/14/ PY - 2013/08/03/received PY - 2013/11/07/accepted PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2015/1/6/medline SP - 815 EP - 21 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 35 IS - 6 N2 - Chemotherapy drugs treatment causes neuropathic pain, hyperalgesia and allodynia are common components of neuropathic pain, so effectively therapeutic strategy is required. In this study, we evaluated the antinociceptive effects of matrine on vincristine-induced neuropathic pain in mice. Vincristine (100 μg/kg i.p.) was administered once per day for 7 days (day 0-6) in mice. Matrine (15, 30, 60 mg/kg, i.p.) was repeated administration in early phase (day 0-6) or late phase (day 7-13). Hyperalgesia and allodynia were evaluated by withdrawal response using von Frey filaments, plantar and cold-plate on 7, 14 and 21 day. Injection of vincristine produced mechanical hyperalgesia and cold allodynia. Matrine was found to produce a protective role in both von Frey filaments and cold-plate test. The analysis of the effect supports the hypothesis that matrine is useful in therapy of vincristine-induced neuropathic pain. In conclusion, this study demonstrates that administration of matrine is associated with antinociceptive effect on mechanical and cold stimuli in a mice model of vincristine-induced neuropathy pain. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/24337989/Antinociceptive_effect_of_matrine_on_vincristine_induced_neuropathic_pain_model_in_mice_ L2 - https://link.springer.com/10.1007/s10072-013-1603-6 DB - PRIME DP - Unbound Medicine ER -