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Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology.
J Sci Food Agric. 2014 Apr; 94(6):1042-56.JS

Abstract

Recent evidence has indicated that a group of plant-derived compounds known as flavonoids may exert particularly powerful actions on mammalian cognition and may reverse age-related declines in memory and learning. In addition, growing evidence is also suggestive that flavonoids may delay the development of Alzheimer's disease-like pathology, suggestive of potential dietary strategies in dementia. Although these low-molecular-weight phytochemicals are absorbed to only a limited degree, they have been found to counteract age-related cognitive declines possibly via their ability to interact with the cellular and molecular architecture of the brain responsible for memory. However, the majority of the research has been carried out at rather supraphysiological concentrations and only a few studies have investigated the neuromodulatory effects of physiologically attainable flavonoid concentrations. This review will summarize the evidence for the effects of flavonoids and their metabolites in age-related cognitive decline and Alzheimer's disease. Mechanisms of actions will be discussed and include those activating signalling pathways critical in controlling synaptic plasticity, reducing neuroinflammation and inducing vascular effects potentially capable of causing new nerve cell growth in the hippocampus. Altogether, these processes are known to be important in maintaining optimal neuronal function, to limit neurodegeneration and to prevent or reverse age-dependent deteriorations in cognitive performance.

Authors+Show Affiliations

Department of Nutrition, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24338740

Citation

Vauzour, David. "Effect of Flavonoids On Learning, Memory and Neurocognitive Performance: Relevance and Potential Implications for Alzheimer's Disease Pathophysiology." Journal of the Science of Food and Agriculture, vol. 94, no. 6, 2014, pp. 1042-56.
Vauzour D. Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology. J Sci Food Agric. 2014;94(6):1042-56.
Vauzour, D. (2014). Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology. Journal of the Science of Food and Agriculture, 94(6), 1042-56. https://doi.org/10.1002/jsfa.6473
Vauzour D. Effect of Flavonoids On Learning, Memory and Neurocognitive Performance: Relevance and Potential Implications for Alzheimer's Disease Pathophysiology. J Sci Food Agric. 2014;94(6):1042-56. PubMed PMID: 24338740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology. A1 - Vauzour,David, Y1 - 2013/12/12/ PY - 2013/03/11/received PY - 2013/10/24/revised PY - 2013/11/08/accepted PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/11/6/medline KW - Alzheimer's disease KW - flavonoids KW - memory KW - signalling pathways SP - 1042 EP - 56 JF - Journal of the science of food and agriculture JO - J Sci Food Agric VL - 94 IS - 6 N2 - Recent evidence has indicated that a group of plant-derived compounds known as flavonoids may exert particularly powerful actions on mammalian cognition and may reverse age-related declines in memory and learning. In addition, growing evidence is also suggestive that flavonoids may delay the development of Alzheimer's disease-like pathology, suggestive of potential dietary strategies in dementia. Although these low-molecular-weight phytochemicals are absorbed to only a limited degree, they have been found to counteract age-related cognitive declines possibly via their ability to interact with the cellular and molecular architecture of the brain responsible for memory. However, the majority of the research has been carried out at rather supraphysiological concentrations and only a few studies have investigated the neuromodulatory effects of physiologically attainable flavonoid concentrations. This review will summarize the evidence for the effects of flavonoids and their metabolites in age-related cognitive decline and Alzheimer's disease. Mechanisms of actions will be discussed and include those activating signalling pathways critical in controlling synaptic plasticity, reducing neuroinflammation and inducing vascular effects potentially capable of causing new nerve cell growth in the hippocampus. Altogether, these processes are known to be important in maintaining optimal neuronal function, to limit neurodegeneration and to prevent or reverse age-dependent deteriorations in cognitive performance. SN - 1097-0010 UR - https://www.unboundmedicine.com/medline/citation/24338740/Effect_of_flavonoids_on_learning_memory_and_neurocognitive_performance:_relevance_and_potential_implications_for_Alzheimer's_disease_pathophysiology_ L2 - https://doi.org/10.1002/jsfa.6473 DB - PRIME DP - Unbound Medicine ER -