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An increasing danger of zoonotic orthopoxvirus infections.
PLoS Pathog 2013; 9(12):e1003756PP

Abstract

On May 8, 1980, the World Health Assembly at its 33(rd) session solemnly declared that the world and all its peoples had won freedom from smallpox and recommended ceasing the vaccination of the population against smallpox. Currently, a larger part of the world population has no immunity not only against smallpox but also against other zoonotic orthopoxvirus infections. Recently, recorded outbreaks of orthopoxvirus diseases not only of domestic animals but also of humans have become more frequent. All this indicates a new situation in the ecology and evolution of zoonotic orthopoxviruses. Analysis of state-of-the-art data on the phylogenetic relationships, ecology, and host range of orthopoxviruses--etiological agents of smallpox (variola virus, VARV), monkeypox (MPXV), cowpox (CPXV), vaccinia (VACV), and camelpox (CMLV)--as well as the patterns of their evolution suggests that a VARV-like virus could emerge in the course of natural evolution of modern zoonotic orthopoxviruses. Thus, there is an insistent need for organization of the international control over the outbreaks of zoonotic orthopoxvirus infections in various countries to provide a rapid response and prevent them from developing into epidemics.

Authors+Show Affiliations

State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk Oblast, Russia ; Novosibirsk State University, Novosibirsk, Russia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24339772

Citation

Shchelkunov, Sergei N.. "An Increasing Danger of Zoonotic Orthopoxvirus Infections." PLoS Pathogens, vol. 9, no. 12, 2013, pp. e1003756.
Shchelkunov SN. An increasing danger of zoonotic orthopoxvirus infections. PLoS Pathog. 2013;9(12):e1003756.
Shchelkunov, S. N. (2013). An increasing danger of zoonotic orthopoxvirus infections. PLoS Pathogens, 9(12), pp. e1003756. doi:10.1371/journal.ppat.1003756.
Shchelkunov SN. An Increasing Danger of Zoonotic Orthopoxvirus Infections. PLoS Pathog. 2013;9(12):e1003756. PubMed PMID: 24339772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An increasing danger of zoonotic orthopoxvirus infections. A1 - Shchelkunov,Sergei N, Y1 - 2013/12/05/ PY - 2013/12/17/entrez PY - 2013/12/18/pubmed PY - 2014/9/4/medline SP - e1003756 EP - e1003756 JF - PLoS pathogens JO - PLoS Pathog. VL - 9 IS - 12 N2 - On May 8, 1980, the World Health Assembly at its 33(rd) session solemnly declared that the world and all its peoples had won freedom from smallpox and recommended ceasing the vaccination of the population against smallpox. Currently, a larger part of the world population has no immunity not only against smallpox but also against other zoonotic orthopoxvirus infections. Recently, recorded outbreaks of orthopoxvirus diseases not only of domestic animals but also of humans have become more frequent. All this indicates a new situation in the ecology and evolution of zoonotic orthopoxviruses. Analysis of state-of-the-art data on the phylogenetic relationships, ecology, and host range of orthopoxviruses--etiological agents of smallpox (variola virus, VARV), monkeypox (MPXV), cowpox (CPXV), vaccinia (VACV), and camelpox (CMLV)--as well as the patterns of their evolution suggests that a VARV-like virus could emerge in the course of natural evolution of modern zoonotic orthopoxviruses. Thus, there is an insistent need for organization of the international control over the outbreaks of zoonotic orthopoxvirus infections in various countries to provide a rapid response and prevent them from developing into epidemics. SN - 1553-7374 UR - https://www.unboundmedicine.com/medline/citation/24339772/An_increasing_danger_of_zoonotic_orthopoxvirus_infections_ L2 - http://dx.plos.org/10.1371/journal.ppat.1003756 DB - PRIME DP - Unbound Medicine ER -