Tags

Type your tag names separated by a space and hit enter

[The importance of folic acid deficiency in the pathogenesis of vascular, mixed and Alzheimer's disease dementia].
Pol Merkur Lekarski 2013; 35(208):205-9PM

Abstract

Alzheimer's disease (AD), vascular dementia (VaD) and mixed dementia (MD) are the most common dementia diseases among the elderly. Currently, there is no effective treatment of these diseases and, therefore, it seems justified to develop the principles of prevention, taking into account the elimination of risk factors. Among them folic acid deficiency may play an important role.

THE AIM OF THE STUDY

To evaluate possible relationship of folate deficiency with the development of selected dementia diseases: vascular dementia (VaD), Alzheimer's disease (AD), mixed dementia (MD).

MATERIAL AND METHODS

The study involved 166 people, including 47 people with the diagnosis of AD, 41 with VaD and 36 with MD. The control group consisted of 42 persons without cognitive impairment. All patients underwent a general physical, neurological, psychiatric and extensive neuropsychological examination, as well as routine blood and biochemical screening tests and neuroimaging. The level of serum folate (Fol) was measured by electrochemiluminescence immunoassay. To assess the correlation of Fol level with the cognitive impairment neuropsychometric scales: Mini Mental State Examination (MMSE) and Clinical Dementia Rating (CDR) were used.

RESULTS

In patients with dementia, compared with the control group, there were significantly lower levels of folic acid (p = 0.04). There was no difference in the concentration of Fol in groups of patients (p = 0.0889). In people without cognitive impairment (CDR 0) levels of folic acid were significantly higher compared to the group with moderate dementia (CDR 2, p = 0.0475).

CONCLUSIONS

The results may suggest that folic acid deficiency is one of the possible causes of dementia, but does not determine its type. Determination of serum Fol in the elderly and supplementation of this vitamin deficiency may play an important role in the prevention of the most common dementias.

Authors+Show Affiliations

Research-Scientific-Didactic Centre of Dementia-Related Diseases in Scinawa, Medical University of Wroclaw, Poland. zbochm@poczta.onet.plDepartment of Psychiatry, Medical University of Wroclaw, Poland.

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

24340890

Citation

Marzena, Zboch, and Leszek Jerzy. "[The Importance of Folic Acid Deficiency in the Pathogenesis of Vascular, Mixed and Alzheimer's Disease Dementia]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 35, no. 208, 2013, pp. 205-9.
Marzena Z, Jerzy L. [The importance of folic acid deficiency in the pathogenesis of vascular, mixed and Alzheimer's disease dementia]. Pol Merkur Lekarski. 2013;35(208):205-9.
Marzena, Z., & Jerzy, L. (2013). [The importance of folic acid deficiency in the pathogenesis of vascular, mixed and Alzheimer's disease dementia]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 35(208), pp. 205-9.
Marzena Z, Jerzy L. [The Importance of Folic Acid Deficiency in the Pathogenesis of Vascular, Mixed and Alzheimer's Disease Dementia]. Pol Merkur Lekarski. 2013;35(208):205-9. PubMed PMID: 24340890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The importance of folic acid deficiency in the pathogenesis of vascular, mixed and Alzheimer's disease dementia]. AU - Marzena,Zboch, AU - Jerzy,Leszek, PY - 2013/12/18/entrez PY - 2013/12/18/pubmed PY - 2014/1/18/medline SP - 205 EP - 9 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 35 IS - 208 N2 - UNLABELLED: Alzheimer's disease (AD), vascular dementia (VaD) and mixed dementia (MD) are the most common dementia diseases among the elderly. Currently, there is no effective treatment of these diseases and, therefore, it seems justified to develop the principles of prevention, taking into account the elimination of risk factors. Among them folic acid deficiency may play an important role. THE AIM OF THE STUDY: To evaluate possible relationship of folate deficiency with the development of selected dementia diseases: vascular dementia (VaD), Alzheimer's disease (AD), mixed dementia (MD). MATERIAL AND METHODS: The study involved 166 people, including 47 people with the diagnosis of AD, 41 with VaD and 36 with MD. The control group consisted of 42 persons without cognitive impairment. All patients underwent a general physical, neurological, psychiatric and extensive neuropsychological examination, as well as routine blood and biochemical screening tests and neuroimaging. The level of serum folate (Fol) was measured by electrochemiluminescence immunoassay. To assess the correlation of Fol level with the cognitive impairment neuropsychometric scales: Mini Mental State Examination (MMSE) and Clinical Dementia Rating (CDR) were used. RESULTS: In patients with dementia, compared with the control group, there were significantly lower levels of folic acid (p = 0.04). There was no difference in the concentration of Fol in groups of patients (p = 0.0889). In people without cognitive impairment (CDR 0) levels of folic acid were significantly higher compared to the group with moderate dementia (CDR 2, p = 0.0475). CONCLUSIONS: The results may suggest that folic acid deficiency is one of the possible causes of dementia, but does not determine its type. Determination of serum Fol in the elderly and supplementation of this vitamin deficiency may play an important role in the prevention of the most common dementias. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/24340890/[The_importance_of_folic_acid_deficiency_in_the_pathogenesis_of_vascular_mixed_and_Alzheimer's_disease_dementia]_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -