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Serum S100A12 concentrations are correlated with angiographic coronary lesion complexity in patients with coronary artery disease.
Scand J Clin Lab Invest. 2014 Mar; 74(2):149-54.SJ

Abstract

The neutrophil activation marker S100A12 is an important pro-inflammatory cytokine and a potential biomarker for a range of inflammatory diseases. This study aims to investigate whether serum S100A12 concentrations are associated with angiographic coronary lesion complexity in patients with coronary artery disease (CAD). We enrolled 240 CAD and 68 healthy controls. Coronary lesion complexity was assessed by coronary angiography (CAG). Serum S100A12 concentrations were detected by enzyme-linked immunosorbent assay (ELISA). We demonstrated that serum S100A12 concentrations were independently associated with the presence of complex lesion in patients with stable angina pectoris (SAP) (Odds ratio 1.02, 95% CI 1.01-1.04; p < 0.01). In addition, among patients with acute coronary syndrome (ACS) who had significantly higher serum S100A12 concentrations than SAP patients (140.8 [interval 109.4-208.6] vs. 120.8 [interval 96.1-145.9] μg/L, respectively, p < 0.01), those with multi-complex lesions had significantly higher serum S100A12 concentrations than those with no or one complex lesion (156.3 [interval 116.2-247.4] vs. 129.2 [interval 99.8-165.2] μg/L, respectively, p < 0.01). These findings suggest that S100A12 in serum might be a potential biomarker for providing valuable information regarding coronary plaque vulnerability in patients with CAD.

Authors+Show Affiliations

Department of Geriatrics, Tangdu Hospital, Fourth Military Medical University , Xian , P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24341566

Citation

Liu, Jun, et al. "Serum S100A12 Concentrations Are Correlated With Angiographic Coronary Lesion Complexity in Patients With Coronary Artery Disease." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 74, no. 2, 2014, pp. 149-54.
Liu J, Ren YG, Zhang LH, et al. Serum S100A12 concentrations are correlated with angiographic coronary lesion complexity in patients with coronary artery disease. Scand J Clin Lab Invest. 2014;74(2):149-54.
Liu, J., Ren, Y. G., Zhang, L. H., Tong, Y. W., & Kang, L. (2014). Serum S100A12 concentrations are correlated with angiographic coronary lesion complexity in patients with coronary artery disease. Scandinavian Journal of Clinical and Laboratory Investigation, 74(2), 149-54. https://doi.org/10.3109/00365513.2013.864786
Liu J, et al. Serum S100A12 Concentrations Are Correlated With Angiographic Coronary Lesion Complexity in Patients With Coronary Artery Disease. Scand J Clin Lab Invest. 2014;74(2):149-54. PubMed PMID: 24341566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum S100A12 concentrations are correlated with angiographic coronary lesion complexity in patients with coronary artery disease. AU - Liu,Jun, AU - Ren,Yin-Gang, AU - Zhang,Li-Hua, AU - Tong,Ya-Wen, AU - Kang,Li, Y1 - 2013/12/16/ PY - 2013/12/18/entrez PY - 2013/12/18/pubmed PY - 2014/11/5/medline SP - 149 EP - 54 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 74 IS - 2 N2 - The neutrophil activation marker S100A12 is an important pro-inflammatory cytokine and a potential biomarker for a range of inflammatory diseases. This study aims to investigate whether serum S100A12 concentrations are associated with angiographic coronary lesion complexity in patients with coronary artery disease (CAD). We enrolled 240 CAD and 68 healthy controls. Coronary lesion complexity was assessed by coronary angiography (CAG). Serum S100A12 concentrations were detected by enzyme-linked immunosorbent assay (ELISA). We demonstrated that serum S100A12 concentrations were independently associated with the presence of complex lesion in patients with stable angina pectoris (SAP) (Odds ratio 1.02, 95% CI 1.01-1.04; p < 0.01). In addition, among patients with acute coronary syndrome (ACS) who had significantly higher serum S100A12 concentrations than SAP patients (140.8 [interval 109.4-208.6] vs. 120.8 [interval 96.1-145.9] μg/L, respectively, p < 0.01), those with multi-complex lesions had significantly higher serum S100A12 concentrations than those with no or one complex lesion (156.3 [interval 116.2-247.4] vs. 129.2 [interval 99.8-165.2] μg/L, respectively, p < 0.01). These findings suggest that S100A12 in serum might be a potential biomarker for providing valuable information regarding coronary plaque vulnerability in patients with CAD. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/24341566/Serum_S100A12_concentrations_are_correlated_with_angiographic_coronary_lesion_complexity_in_patients_with_coronary_artery_disease_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365513.2013.864786 DB - PRIME DP - Unbound Medicine ER -