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Pepper seed extract suppresses invasion and migration of human breast cancer cells.
Nutr Cancer. 2014; 66(1):159-65.NC

Abstract

This study was performed to determine the antimetastatic activities of chili pepper seed on human breast cancer cells. The water extract of chili pepper seeds was prepared and it contained a substantial amount of phenols (131.12 mg%) and no capsaicinoids. Pepper seed extract (PSE) suppressed the proliferation of MDA-MB-231 and MCF-7 cells at the concentration of 10, 25, and 50 μg/ml (MDA-MB-231: IC50 = 20.1 μg/ml, MCF-7: IC50 = 14.7 μg/ml). PSE increased the expression level of E-cadherin up to 1.2-fold of the control in MCF-7 cells. PSE also decreased the secretion of matrix metalloproteinase (MMP)-2 and MMP-9 in MDA-MB-231 and MCF-7 cells at the concentration of 25 and 50 μg/ml. PSE treatment significantly suppressed the invasion of MDA-MB-231 and MCF-7 cells in a dose-dependent manner. The motility of cancer cells was apparently retarded in the wound healing assay by the PSE treatment. Although our data collectively demonstrate that PSE inhibits invasion and migration of breast cancer cells, further study is needed to identify specific mechanisms and bioactive components contributing to antimetastatic effects of chili pepper seed.

Authors+Show Affiliations

a Department of Food & Nutrition , Mokpo National University , Jeonnam , Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24341783

Citation

Kim, Hyeon-A, et al. "Pepper Seed Extract Suppresses Invasion and Migration of Human Breast Cancer Cells." Nutrition and Cancer, vol. 66, no. 1, 2014, pp. 159-65.
Kim HA, Kim MS, Kim SH, et al. Pepper seed extract suppresses invasion and migration of human breast cancer cells. Nutr Cancer. 2014;66(1):159-65.
Kim, H. A., Kim, M. S., Kim, S. H., & Kim, Y. K. (2014). Pepper seed extract suppresses invasion and migration of human breast cancer cells. Nutrition and Cancer, 66(1), 159-65. https://doi.org/10.1080/01635581.2014.853814
Kim HA, et al. Pepper Seed Extract Suppresses Invasion and Migration of Human Breast Cancer Cells. Nutr Cancer. 2014;66(1):159-65. PubMed PMID: 24341783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pepper seed extract suppresses invasion and migration of human breast cancer cells. AU - Kim,Hyeon-A, AU - Kim,Min-Sook, AU - Kim,Sang-Hyun, AU - Kim,Yoo Kyeong, Y1 - 2013/12/16/ PY - 2013/12/18/entrez PY - 2013/12/18/pubmed PY - 2014/9/4/medline SP - 159 EP - 65 JF - Nutrition and cancer JO - Nutr Cancer VL - 66 IS - 1 N2 - This study was performed to determine the antimetastatic activities of chili pepper seed on human breast cancer cells. The water extract of chili pepper seeds was prepared and it contained a substantial amount of phenols (131.12 mg%) and no capsaicinoids. Pepper seed extract (PSE) suppressed the proliferation of MDA-MB-231 and MCF-7 cells at the concentration of 10, 25, and 50 μg/ml (MDA-MB-231: IC50 = 20.1 μg/ml, MCF-7: IC50 = 14.7 μg/ml). PSE increased the expression level of E-cadherin up to 1.2-fold of the control in MCF-7 cells. PSE also decreased the secretion of matrix metalloproteinase (MMP)-2 and MMP-9 in MDA-MB-231 and MCF-7 cells at the concentration of 25 and 50 μg/ml. PSE treatment significantly suppressed the invasion of MDA-MB-231 and MCF-7 cells in a dose-dependent manner. The motility of cancer cells was apparently retarded in the wound healing assay by the PSE treatment. Although our data collectively demonstrate that PSE inhibits invasion and migration of breast cancer cells, further study is needed to identify specific mechanisms and bioactive components contributing to antimetastatic effects of chili pepper seed. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/24341783/Pepper_seed_extract_suppresses_invasion_and_migration_of_human_breast_cancer_cells_ L2 - https://www.tandfonline.com/doi/full/10.1080/01635581.2014.853814 DB - PRIME DP - Unbound Medicine ER -