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Flavonol intake and stroke risk: a meta-analysis of cohort studies.
Nutrition 2014; 30(5):518-23N

Abstract

OBJECTIVE

Epidemiologic findings are inconsistent regarding the association between flavonol intake and the risk for stroke. The aim of this study was to determine whether an association exists between them in observational studies.

METHODS

We searched the PubMed and EMBASE databases for studies conducted from 1966 to August 2013. Prospective cohort studies that provided relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between flavonol intake and risk for stroke were included. A random effects model was used to combine study-specific risk estimates.

RESULTS

The meta-analysis included eight studies, with 5228 stroke cases among 280 174 participants. The summary RR indicated a significant association between highest flavonol intake and reduced risk for stroke (summary RR, 0.86; 95% CI, 0.75-0.99). Furthermore, an increase in flavonol intake of 20 mg/d was associated with a 14% decrease in the risk for developing stroke (summary RR, 0.86; 95% CI, 0.77-0.96). Subgroup analyses suggested a significant inverse association between highest flavonol intake and stroke risk among men (summary RR, 0.74; 95% CI, 0.56-0.97) but not women (summary RR, 0.99; 95% CI, 0.85-1.16).

CONCLUSIONS

Higher dietary flavonol intake is associated with a reduced risk for stroke, especially among men. Our results support recommendations for higher consumption of flavonol-rich foods to prevent stroke.

Authors+Show Affiliations

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Jiangsu Center of Safety Evaluation for Drugs, Nanjing University of Technology, Nanjing, China.Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: Drlswang@njmu.edu.cn.Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: zhijianyangnj@njmu.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24342529

Citation

Wang, Ze-Mu, et al. "Flavonol Intake and Stroke Risk: a Meta-analysis of Cohort Studies." Nutrition (Burbank, Los Angeles County, Calif.), vol. 30, no. 5, 2014, pp. 518-23.
Wang ZM, Zhao D, Nie ZL, et al. Flavonol intake and stroke risk: a meta-analysis of cohort studies. Nutrition. 2014;30(5):518-23.
Wang, Z. M., Zhao, D., Nie, Z. L., Zhao, H., Zhou, B., Gao, W., ... Yang, Z. J. (2014). Flavonol intake and stroke risk: a meta-analysis of cohort studies. Nutrition (Burbank, Los Angeles County, Calif.), 30(5), pp. 518-23. doi:10.1016/j.nut.2013.10.009.
Wang ZM, et al. Flavonol Intake and Stroke Risk: a Meta-analysis of Cohort Studies. Nutrition. 2014;30(5):518-23. PubMed PMID: 24342529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonol intake and stroke risk: a meta-analysis of cohort studies. AU - Wang,Ze-Mu, AU - Zhao,Di, AU - Nie,Zhen-Lin, AU - Zhao,Huan, AU - Zhou,Bo, AU - Gao,Wei, AU - Wang,Lian-Sheng, AU - Yang,Zhi-Jian, Y1 - 2013/10/19/ PY - 2013/06/01/received PY - 2013/09/14/revised PY - 2013/10/15/accepted PY - 2013/12/18/entrez PY - 2013/12/18/pubmed PY - 2014/12/15/medline KW - Dose-response KW - Flavonol KW - Meta-analysis KW - Prospective studies KW - Stroke SP - 518 EP - 23 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 30 IS - 5 N2 - OBJECTIVE: Epidemiologic findings are inconsistent regarding the association between flavonol intake and the risk for stroke. The aim of this study was to determine whether an association exists between them in observational studies. METHODS: We searched the PubMed and EMBASE databases for studies conducted from 1966 to August 2013. Prospective cohort studies that provided relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between flavonol intake and risk for stroke were included. A random effects model was used to combine study-specific risk estimates. RESULTS: The meta-analysis included eight studies, with 5228 stroke cases among 280 174 participants. The summary RR indicated a significant association between highest flavonol intake and reduced risk for stroke (summary RR, 0.86; 95% CI, 0.75-0.99). Furthermore, an increase in flavonol intake of 20 mg/d was associated with a 14% decrease in the risk for developing stroke (summary RR, 0.86; 95% CI, 0.77-0.96). Subgroup analyses suggested a significant inverse association between highest flavonol intake and stroke risk among men (summary RR, 0.74; 95% CI, 0.56-0.97) but not women (summary RR, 0.99; 95% CI, 0.85-1.16). CONCLUSIONS: Higher dietary flavonol intake is associated with a reduced risk for stroke, especially among men. Our results support recommendations for higher consumption of flavonol-rich foods to prevent stroke. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/24342529/Flavonol_intake_and_stroke_risk:_a_meta_analysis_of_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(13)00457-7 DB - PRIME DP - Unbound Medicine ER -