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Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia.
J Ethnopharmacol. 2014 Feb 03; 151(2):970-4.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Cydonia oblonga Mill. leaves are traditionally used in Uyghur medicine to treat or prevent cardiovascular disease. Beyond a demonstrated effect on thrombosis, we tested it for an effect on dyslipidemia, in a rat model of hyperlipidemia.

METHODS

Seventy healthy Sprague Dawley rats were randomly divided into 6 groups: normal controls, model controls, simvastatin, and low-, medium- and high-dose Cydonia oblonga Mill. leaf extracts (COM), orally for 56 days. The normal controls were fed a normal diet, all other groups a high fat diet. Rat weights were recorded over time. Total cholesterol (TC), triglycerides (TG), low and high-density lipoproteins (LDL, HDL), as well as AST, ALT and total protein (TP) were measured in serum at the end of the study. The antioxidant capacity of glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), malondialdehyde (MDA) was measured in liver samples, along with lipoprotein lipase (LPL), and hepatic lipase (HL). Liver pathology was described.

RESULTS

COM dose-dependently reduced TC, TG, LDL-C and MDA, inhibited the activity of ALT, AST and LPS, increased HDL-C content, increased the activity of SOD, GSH-PX, LPL and HL, and reduced liver steatosis in hyperlipidaemia rats, which was significant at medium and high doses. The effect of COM was similar to that of simvastatin except for increased LPL and HL which were reduced by COM but not by simvastatin.

CONCLUSION

Cydonia oblonga Mill. leaf extracts have hypolipidaemic and hepatoprotective effects, probably related to increasing antioxidant capacity and lipoprotein metabolism in the liver, and inhibition of lipogenesis.

Authors+Show Affiliations

Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China.Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China.Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China.Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China.Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China.Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China.Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China; Department of Pharmacology, University Bordeaux Segalen, 146 rue Leo Saignat, 33076 Bordeaux, France. Electronic address: nicholas.moore@pharmaco.u-bordeaux2.fr.Department of Pharmacology, Xinjiang Medical University, 393 Xinyi Road, 830011 Urumqi, PR China; Department of Pharmacology, University Bordeaux Segalen, 146 rue Leo Saignat, 33076 Bordeaux, France. Electronic address: anwar.umar@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24342780

Citation

Abliz, Ablat, et al. "Effect of Cydonia Oblonga Mill. Leaf Extract On Serum Lipids and Liver Function in a Rat Model of Hyperlipidaemia." Journal of Ethnopharmacology, vol. 151, no. 2, 2014, pp. 970-4.
Abliz A, Aji Q, Abdusalam E, et al. Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia. J Ethnopharmacol. 2014;151(2):970-4.
Abliz, A., Aji, Q., Abdusalam, E., Sun, X., Abdurahman, A., Zhou, W., Moore, N., & Umar, A. (2014). Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia. Journal of Ethnopharmacology, 151(2), 970-4. https://doi.org/10.1016/j.jep.2013.12.010
Abliz A, et al. Effect of Cydonia Oblonga Mill. Leaf Extract On Serum Lipids and Liver Function in a Rat Model of Hyperlipidaemia. J Ethnopharmacol. 2014 Feb 3;151(2):970-4. PubMed PMID: 24342780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia. AU - Abliz,Ablat, AU - Aji,Qimangul, AU - Abdusalam,Elzira, AU - Sun,Xiaowei, AU - Abdurahman,Adil, AU - Zhou,Wenting, AU - Moore,Nicholas, AU - Umar,Anwar, Y1 - 2013/12/14/ PY - 2013/09/23/received PY - 2013/11/22/revised PY - 2013/12/06/accepted PY - 2013/12/18/entrez PY - 2013/12/18/pubmed PY - 2014/9/18/medline KW - ALT KW - AST KW - Antioxidant KW - COM KW - Cydonia oblonga Mill. KW - Cydonia oblonga Mill. leaf extract KW - GSH-PX KW - HDL-C KW - HL KW - Hypercholesterolemia KW - Hyperlipidaemia KW - Hypolipidemic effect KW - LDL-C KW - LPL KW - LPS KW - MDA KW - SOD KW - TC KW - TG KW - TP KW - Traditional Uyghur medicine KW - alanine transaminase KW - aspartate transaminase KW - glutathione peroxidase KW - hepatic lipase KW - high density lipoprotein cholesterol KW - lipase KW - lipoprotein lipase KW - low-density lipoprotein cholesterol KW - malondialdehyde KW - superoxide dismutase KW - total cholesterol KW - total protein KW - triglycerides SP - 970 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 151 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Cydonia oblonga Mill. leaves are traditionally used in Uyghur medicine to treat or prevent cardiovascular disease. Beyond a demonstrated effect on thrombosis, we tested it for an effect on dyslipidemia, in a rat model of hyperlipidemia. METHODS: Seventy healthy Sprague Dawley rats were randomly divided into 6 groups: normal controls, model controls, simvastatin, and low-, medium- and high-dose Cydonia oblonga Mill. leaf extracts (COM), orally for 56 days. The normal controls were fed a normal diet, all other groups a high fat diet. Rat weights were recorded over time. Total cholesterol (TC), triglycerides (TG), low and high-density lipoproteins (LDL, HDL), as well as AST, ALT and total protein (TP) were measured in serum at the end of the study. The antioxidant capacity of glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), malondialdehyde (MDA) was measured in liver samples, along with lipoprotein lipase (LPL), and hepatic lipase (HL). Liver pathology was described. RESULTS: COM dose-dependently reduced TC, TG, LDL-C and MDA, inhibited the activity of ALT, AST and LPS, increased HDL-C content, increased the activity of SOD, GSH-PX, LPL and HL, and reduced liver steatosis in hyperlipidaemia rats, which was significant at medium and high doses. The effect of COM was similar to that of simvastatin except for increased LPL and HL which were reduced by COM but not by simvastatin. CONCLUSION: Cydonia oblonga Mill. leaf extracts have hypolipidaemic and hepatoprotective effects, probably related to increasing antioxidant capacity and lipoprotein metabolism in the liver, and inhibition of lipogenesis. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/24342780/Effect_of_Cydonia_oblonga_Mill__leaf_extract_on_serum_lipids_and_liver_function_in_a_rat_model_of_hyperlipidaemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00873-8 DB - PRIME DP - Unbound Medicine ER -