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Dyslipidemia, malnutrition, inflammation, cardiovascular disease and mortality in chronic kidney disease.
Curr Opin Lipidol. 2014 Feb; 25(1):54-60.CO

Abstract

PURPOSE OF REVIEW

Dyslipidemia, malnutrition and inflammation are common in patients with chronic kidney disease (CKD) and are strongly associated with cardiovascular disease (CVD) and increased mortality. The epidemiology of dyslipidemia and its interactions with malnutrition and inflammation in CKD patients have been the subject of much interest in the past decade. Recent clinical trials have explored the effects of statins on CVD specifically in CKD patients.

RECENT FINDINGS

Whereas the risk relationship between total cholesterol level and CVD morbidity and mortality is direct, strong and progressive in CKD patients without malnutrition and inflammation, it is inconsistent and often paradoxical in those with malnutrition and inflammation. Accumulating evidence demonstrates that statins reduce significantly the risk of CVD in CKD patients before the initiation of dialysis. However, the beneficial effect of statins in CKD patients on dialysis is uncertain. In CKD patients on dialysis, malnutrition and inflammation pose a higher risk for CVD than dyslipidemia.

SUMMARY

In CKD patients, the risk of CVD associated to dyslipidemia is complex and is modified by malnutrition and inflammation.

Authors+Show Affiliations

University of Miami Miller School of Medicine, Miami, Florida, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24345987

Citation

Peev, Vasil, et al. "Dyslipidemia, Malnutrition, Inflammation, Cardiovascular Disease and Mortality in Chronic Kidney Disease." Current Opinion in Lipidology, vol. 25, no. 1, 2014, pp. 54-60.
Peev V, Nayer A, Contreras G. Dyslipidemia, malnutrition, inflammation, cardiovascular disease and mortality in chronic kidney disease. Curr Opin Lipidol. 2014;25(1):54-60.
Peev, V., Nayer, A., & Contreras, G. (2014). Dyslipidemia, malnutrition, inflammation, cardiovascular disease and mortality in chronic kidney disease. Current Opinion in Lipidology, 25(1), 54-60. https://doi.org/10.1097/MOL.0000000000000045
Peev V, Nayer A, Contreras G. Dyslipidemia, Malnutrition, Inflammation, Cardiovascular Disease and Mortality in Chronic Kidney Disease. Curr Opin Lipidol. 2014;25(1):54-60. PubMed PMID: 24345987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyslipidemia, malnutrition, inflammation, cardiovascular disease and mortality in chronic kidney disease. AU - Peev,Vasil, AU - Nayer,Ali, AU - Contreras,Gabriel, PY - 2013/12/19/entrez PY - 2013/12/19/pubmed PY - 2014/9/5/medline SP - 54 EP - 60 JF - Current opinion in lipidology JO - Curr Opin Lipidol VL - 25 IS - 1 N2 - PURPOSE OF REVIEW: Dyslipidemia, malnutrition and inflammation are common in patients with chronic kidney disease (CKD) and are strongly associated with cardiovascular disease (CVD) and increased mortality. The epidemiology of dyslipidemia and its interactions with malnutrition and inflammation in CKD patients have been the subject of much interest in the past decade. Recent clinical trials have explored the effects of statins on CVD specifically in CKD patients. RECENT FINDINGS: Whereas the risk relationship between total cholesterol level and CVD morbidity and mortality is direct, strong and progressive in CKD patients without malnutrition and inflammation, it is inconsistent and often paradoxical in those with malnutrition and inflammation. Accumulating evidence demonstrates that statins reduce significantly the risk of CVD in CKD patients before the initiation of dialysis. However, the beneficial effect of statins in CKD patients on dialysis is uncertain. In CKD patients on dialysis, malnutrition and inflammation pose a higher risk for CVD than dyslipidemia. SUMMARY: In CKD patients, the risk of CVD associated to dyslipidemia is complex and is modified by malnutrition and inflammation. SN - 1473-6535 UR - https://www.unboundmedicine.com/medline/citation/24345987/Dyslipidemia_malnutrition_inflammation_cardiovascular_disease_and_mortality_in_chronic_kidney_disease_ DB - PRIME DP - Unbound Medicine ER -