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Serum levels of trace elements and heavy metals in patients with acute hemorrhagic stroke.
J Membr Biol 2014; 247(2):175-80JM

Abstract

Trace elements are essential components of biological structures, but alternatively, they can be toxic at concentrations beyond those necessary for their biological functions. Changes in the concentration of essential trace elements and heavy metals may affect acute hemorrhagic stroke. The aim of this study was to measure serum levels of essential trace elements [iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), and magnesium (Mg)] and heavy metals [cobalt (Co), cadmium (Cd), and lead (Pb)] in patients with acute hemorrhagic stroke. Twenty-six patients with acute hemorrhagic stroke and 29 healthy controls were enrolled. Atomic absorption spectrophotometry (UNICAM-929) was used to measure serum Fe, Cu, Pb, Cd, Zn, Co, Mn and Mg concentrations. Serum Cd, Pb and Fe levels were significantly higher in patients with acute hemorrhagic stroke than controls (p < 0.001), while serum Cu, Zn, Mg and Mn levels were significantly lower (all p < 0.001). However, there was no significant difference between the groups with respect to serum Co levels (p > 0.05). We first demonstrate increased Cd, Pb, and Fe levels; and decreased Cu, Zn, Mg, and Mn levels in patients with acute hemorrhagic stroke. These findings may have diagnostic and prognostic value for acute hemorrhagic stroke. Further studies are required to elucidate the roles of trace elements and heavy metals in patients with acute hemorrhagic stroke.

Authors+Show Affiliations

Department of Emergency Medicine, Medical Faculty, Yuzuncu Yıl University, Van, Turkey, sevdegulkaradas@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24346187

Citation

Karadas, Sevdegul, et al. "Serum Levels of Trace Elements and Heavy Metals in Patients With Acute Hemorrhagic Stroke." The Journal of Membrane Biology, vol. 247, no. 2, 2014, pp. 175-80.
Karadas S, Sayın R, Aslan M, et al. Serum levels of trace elements and heavy metals in patients with acute hemorrhagic stroke. J Membr Biol. 2014;247(2):175-80.
Karadas, S., Sayın, R., Aslan, M., Gonullu, H., Katı, C., Dursun, R., ... Demir, H. (2014). Serum levels of trace elements and heavy metals in patients with acute hemorrhagic stroke. The Journal of Membrane Biology, 247(2), pp. 175-80. doi:10.1007/s00232-013-9621-0.
Karadas S, et al. Serum Levels of Trace Elements and Heavy Metals in Patients With Acute Hemorrhagic Stroke. J Membr Biol. 2014;247(2):175-80. PubMed PMID: 24346187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of trace elements and heavy metals in patients with acute hemorrhagic stroke. AU - Karadas,Sevdegul, AU - Sayın,Refah, AU - Aslan,Mehmet, AU - Gonullu,Hayriye, AU - Katı,Celal, AU - Dursun,Recep, AU - Duran,Latif, AU - Gonullu,Edip, AU - Demir,Halit, Y1 - 2013/12/18/ PY - 2013/07/24/received PY - 2013/12/05/accepted PY - 2013/12/19/entrez PY - 2013/12/19/pubmed PY - 2014/10/10/medline SP - 175 EP - 80 JF - The Journal of membrane biology JO - J. Membr. Biol. VL - 247 IS - 2 N2 - Trace elements are essential components of biological structures, but alternatively, they can be toxic at concentrations beyond those necessary for their biological functions. Changes in the concentration of essential trace elements and heavy metals may affect acute hemorrhagic stroke. The aim of this study was to measure serum levels of essential trace elements [iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), and magnesium (Mg)] and heavy metals [cobalt (Co), cadmium (Cd), and lead (Pb)] in patients with acute hemorrhagic stroke. Twenty-six patients with acute hemorrhagic stroke and 29 healthy controls were enrolled. Atomic absorption spectrophotometry (UNICAM-929) was used to measure serum Fe, Cu, Pb, Cd, Zn, Co, Mn and Mg concentrations. Serum Cd, Pb and Fe levels were significantly higher in patients with acute hemorrhagic stroke than controls (p < 0.001), while serum Cu, Zn, Mg and Mn levels were significantly lower (all p < 0.001). However, there was no significant difference between the groups with respect to serum Co levels (p > 0.05). We first demonstrate increased Cd, Pb, and Fe levels; and decreased Cu, Zn, Mg, and Mn levels in patients with acute hemorrhagic stroke. These findings may have diagnostic and prognostic value for acute hemorrhagic stroke. Further studies are required to elucidate the roles of trace elements and heavy metals in patients with acute hemorrhagic stroke. SN - 1432-1424 UR - https://www.unboundmedicine.com/medline/citation/24346187/Serum_levels_of_trace_elements_and_heavy_metals_in_patients_with_acute_hemorrhagic_stroke_ L2 - https://dx.doi.org/10.1007/s00232-013-9621-0 DB - PRIME DP - Unbound Medicine ER -