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Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans.
Eur J Clin Nutr. 2014 Feb; 68(2):178-83.EJ

Abstract

BACKGROUND/OBJECTIVES

The objective of this study was to describe serum lipid concentrations, including apolipoproteins A-I and B, in different diet groups.

SUBJECTS/METHODS

A cross-sectional analysis of a sample of 424 meat-eaters, 425 fish-eaters, 423 vegetarians and 422 vegans, matched on sex and age, from the European Prospective Investigation into Cancer and Nutrition-Oxford cohort. Serum concentrations of total, and high-density lipoprotein (HDL) cholesterol, as well as apolipoproteins A-I and B were measured, and serum non-HDL cholesterol was calculated.

RESULTS

Vegans had the lowest body mass index (BMI) and the highest and lowest intakes of polyunsaturated and saturated fat, respectively. After adjustment for age, alcohol and physical activity, compared with meat-eaters, fish-eaters and vegetarians, serum concentrations of total and non-HDL cholesterol and apolipoprotein B were significantly lower in vegans. Serum apolipoprotein A-I concentrations did not differ between the diet groups. In males, the mean serum total cholesterol concentration was 0.87 mmol/l lower in vegans than in meat-eaters; after further adjustment for BMI this difference was 0.76 mmol/l. In females, the difference in total cholesterol between these two groups was 0.6 mmol/l, and after further adjustment for BMI was 0.55 mmol/l. [corrected].

CONCLUSIONS

In this study, which included a large number of vegans, serum total cholesterol and apolipoprotein B concentrations were lower in vegans compared with meat-eaters, fish-eaters and vegetarians. A small proportion of the observed differences in serum lipid concentrations was explained by differences in BMI, but a large proportion is most likely due to diet.

Authors+Show Affiliations

Cancer Epidemiology Unit, Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Department of Population Health, University of Oxford, Oxford, UK.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24346473

Citation

Bradbury, K E., et al. "Serum Concentrations of Cholesterol, Apolipoprotein A-I and Apolipoprotein B in a Total of 1694 Meat-eaters, Fish-eaters, Vegetarians and Vegans." European Journal of Clinical Nutrition, vol. 68, no. 2, 2014, pp. 178-83.
Bradbury KE, Crowe FL, Appleby PN, et al. Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans. Eur J Clin Nutr. 2014;68(2):178-83.
Bradbury, K. E., Crowe, F. L., Appleby, P. N., Schmidt, J. A., Travis, R. C., & Key, T. J. (2014). Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans. European Journal of Clinical Nutrition, 68(2), 178-83. https://doi.org/10.1038/ejcn.2013.248
Bradbury KE, et al. Serum Concentrations of Cholesterol, Apolipoprotein A-I and Apolipoprotein B in a Total of 1694 Meat-eaters, Fish-eaters, Vegetarians and Vegans. Eur J Clin Nutr. 2014;68(2):178-83. PubMed PMID: 24346473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans. AU - Bradbury,K E, AU - Crowe,F L, AU - Appleby,P N, AU - Schmidt,J A, AU - Travis,R C, AU - Key,T J, Y1 - 2013/12/18/ PY - 2013/04/24/received PY - 2013/09/03/revised PY - 2013/10/29/accepted PY - 2013/12/19/entrez PY - 2013/12/19/pubmed PY - 2014/9/30/medline SP - 178 EP - 83 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 68 IS - 2 N2 - BACKGROUND/OBJECTIVES: The objective of this study was to describe serum lipid concentrations, including apolipoproteins A-I and B, in different diet groups. SUBJECTS/METHODS: A cross-sectional analysis of a sample of 424 meat-eaters, 425 fish-eaters, 423 vegetarians and 422 vegans, matched on sex and age, from the European Prospective Investigation into Cancer and Nutrition-Oxford cohort. Serum concentrations of total, and high-density lipoprotein (HDL) cholesterol, as well as apolipoproteins A-I and B were measured, and serum non-HDL cholesterol was calculated. RESULTS: Vegans had the lowest body mass index (BMI) and the highest and lowest intakes of polyunsaturated and saturated fat, respectively. After adjustment for age, alcohol and physical activity, compared with meat-eaters, fish-eaters and vegetarians, serum concentrations of total and non-HDL cholesterol and apolipoprotein B were significantly lower in vegans. Serum apolipoprotein A-I concentrations did not differ between the diet groups. In males, the mean serum total cholesterol concentration was 0.87 mmol/l lower in vegans than in meat-eaters; after further adjustment for BMI this difference was 0.76 mmol/l. In females, the difference in total cholesterol between these two groups was 0.6 mmol/l, and after further adjustment for BMI was 0.55 mmol/l. [corrected]. CONCLUSIONS: In this study, which included a large number of vegans, serum total cholesterol and apolipoprotein B concentrations were lower in vegans compared with meat-eaters, fish-eaters and vegetarians. A small proportion of the observed differences in serum lipid concentrations was explained by differences in BMI, but a large proportion is most likely due to diet. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/24346473/Serum_concentrations_of_cholesterol_apolipoprotein_A_I_and_apolipoprotein_B_in_a_total_of_1694_meat_eaters_fish_eaters_vegetarians_and_vegans_ L2 - https://doi.org/10.1038/ejcn.2013.248 DB - PRIME DP - Unbound Medicine ER -