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Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma.
An Bras Dermatol. 2013 Nov-Dec; 88(6 Suppl 1):32-5.AB

Abstract

A 57-year-old woman presented with periorbital ecchymoses, laxity in skin folds, polyneuropathy and bilateral carpal tunnel syndrome. A skin biopsy of the axillary lesion demonstrated fragmentation of elastic fibers, but with a negative von Kossa stain, consistent with cutis laxa. The diagnosis of primary systemic amyloidosis was made by the presence of amyloid material in the eyelid using histopathological techniques, besides this, the patient was also diagnosed with purpura, polyneuropathy, bilateral carpal tunnel syndrome and monoclonal gammopathy. She was diagnosed as suffering from multiple myeloma based on the finding of 40% plasma cells in the bone marrow, component M in the urine and anemia. The patient developed blisters with a clear content, confirmed as mucinosis by the histopathological exam. The final diagnoses were: primary systemic amyloidosis, acquired cutis laxa and mucinosis, all related to multiple myeloma.

Authors+Show Affiliations

Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.Rio de Janeiro Federal University, Rio de JaneiroRJ, Brazil.Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.Rio de Janeiro State University, Pedro Ernesto University Hospital, Rio de JaneiroRJ, Brazil.Rio de Janeiro State University.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24346874

Citation

Lavorato, Fernanda Guedes, et al. "Primary Systemic Amyloidosis, Acquired Cutis Laxa and Cutaneous Mucinosis in a Patient With Multiple Myeloma." Anais Brasileiros De Dermatologia, vol. 88, no. 6 Suppl 1, 2013, pp. 32-5.
Lavorato FG, Alves Mde F, Maceira JM, et al. Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. An Bras Dermatol. 2013;88(6 Suppl 1):32-5.
Lavorato, F. G., Alves, M. d. e. . F., Maceira, J. M., Unterstell, N., Serpa, L. A., & Azulay-Abulafia, L. (2013). Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. Anais Brasileiros De Dermatologia, 88(6 Suppl 1), 32-5. https://doi.org/10.1590/abd1806-4841.20132531
Lavorato FG, et al. Primary Systemic Amyloidosis, Acquired Cutis Laxa and Cutaneous Mucinosis in a Patient With Multiple Myeloma. An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):32-5. PubMed PMID: 24346874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. AU - Lavorato,Fernanda Guedes, AU - Alves,Maria de Fátima Guimarães Scotelaro, AU - Maceira,Juan Manuel Piñeiro, AU - Unterstell,Natasha, AU - Serpa,Laura Araújo, AU - Azulay-Abulafia,Luna, PY - 2013/02/11/received PY - 2013/05/18/accepted PY - 2013/12/19/entrez PY - 2013/12/19/pubmed PY - 2014/5/17/medline SP - 32 EP - 5 JF - Anais brasileiros de dermatologia JO - An Bras Dermatol VL - 88 IS - 6 Suppl 1 N2 - A 57-year-old woman presented with periorbital ecchymoses, laxity in skin folds, polyneuropathy and bilateral carpal tunnel syndrome. A skin biopsy of the axillary lesion demonstrated fragmentation of elastic fibers, but with a negative von Kossa stain, consistent with cutis laxa. The diagnosis of primary systemic amyloidosis was made by the presence of amyloid material in the eyelid using histopathological techniques, besides this, the patient was also diagnosed with purpura, polyneuropathy, bilateral carpal tunnel syndrome and monoclonal gammopathy. She was diagnosed as suffering from multiple myeloma based on the finding of 40% plasma cells in the bone marrow, component M in the urine and anemia. The patient developed blisters with a clear content, confirmed as mucinosis by the histopathological exam. The final diagnoses were: primary systemic amyloidosis, acquired cutis laxa and mucinosis, all related to multiple myeloma. SN - 1806-4841 UR - https://www.unboundmedicine.com/medline/citation/24346874/Primary_systemic_amyloidosis_acquired_cutis_laxa_and_cutaneous_mucinosis_in_a_patient_with_multiple_myeloma_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24346874/ DB - PRIME DP - Unbound Medicine ER -