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Impact of six rounds of mass drug administration on Brugian filariasis and soil-transmitted helminth infections in eastern Indonesia.
PLoS Negl Trop Dis. 2013; 7(12):e2586.PN

Abstract

BACKGROUND

The lymphatic filarial parasite Brugia timori occurs only in eastern Indonesia where it causes high morbidity. The absence of an animal reservoir, the inefficient transmission by Anopheles mosquitoes and the high sensitivity to DEC/albendazole treatment make this species a prime candidate for elimination by mass drug administration (MDA).

METHODOLOGY/PRINCIPAL FINDINGS

We evaluated the effect of MDA using DEC and albendazole on B. timori and soil transmitted helminths (STH) in a cross-sectional study of a sentinel village on Alor Island annually over a period of 10 years. Pre-MDA the microfilaria (MF) prevalence was 26% and 80% of the residents had filaria-specific IgG4 antibodies. In 2010, 34 months after the 6(th) round of MDA, MF and antibody rates were only 0.17% and 6.4%, respectively. The MDA campaign had also a beneficial effect on STH. Baseline prevalence rates for Ascaris, hookworm and Trichuris were 34%, 28%, and 11%, respectively; these rates were reduced to 27%, 4%, and 2% one year after the 5(th) round of MDA. Unfortunately, STH rates rebounded 34 months after cessation of MDA and approached pre-MDA rates. However, the intensity of STH infection in 2009 was still reduced, and no heavy infections were detected.

CONCLUSIONS/SIGNIFICANCE

MDA with DEC/albendazole has had a major impact on B. timori MF and IgG4 antibody rates, providing a proof of principle that elimination is feasible. We also documented the value of annual DEC/albendazole as a mass de-worming intervention and the importance of continuing some form of STH control after cessation of MDA for filariasis.

Authors+Show Affiliations

Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.Global Health Programs, GlaxoSmithKline, Brentford, Middlesex, United Kingdom.Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia.German International Co-operation (GIZ), Kupang, Indonesia.Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24349595

Citation

Supali, Taniawati, et al. "Impact of Six Rounds of Mass Drug Administration On Brugian Filariasis and Soil-transmitted Helminth Infections in Eastern Indonesia." PLoS Neglected Tropical Diseases, vol. 7, no. 12, 2013, pp. e2586.
Supali T, Djuardi Y, Bradley M, et al. Impact of six rounds of mass drug administration on Brugian filariasis and soil-transmitted helminth infections in eastern Indonesia. PLoS Negl Trop Dis. 2013;7(12):e2586.
Supali, T., Djuardi, Y., Bradley, M., Noordin, R., Rückert, P., & Fischer, P. U. (2013). Impact of six rounds of mass drug administration on Brugian filariasis and soil-transmitted helminth infections in eastern Indonesia. PLoS Neglected Tropical Diseases, 7(12), e2586. https://doi.org/10.1371/journal.pntd.0002586
Supali T, et al. Impact of Six Rounds of Mass Drug Administration On Brugian Filariasis and Soil-transmitted Helminth Infections in Eastern Indonesia. PLoS Negl Trop Dis. 2013;7(12):e2586. PubMed PMID: 24349595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of six rounds of mass drug administration on Brugian filariasis and soil-transmitted helminth infections in eastern Indonesia. AU - Supali,Taniawati, AU - Djuardi,Yenny, AU - Bradley,Mark, AU - Noordin,Rahmah, AU - Rückert,Paul, AU - Fischer,Peter U, Y1 - 2013/12/12/ PY - 2013/07/10/received PY - 2013/10/30/accepted PY - 2013/12/19/entrez PY - 2013/12/19/pubmed PY - 2014/7/30/medline SP - e2586 EP - e2586 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 7 IS - 12 N2 - BACKGROUND: The lymphatic filarial parasite Brugia timori occurs only in eastern Indonesia where it causes high morbidity. The absence of an animal reservoir, the inefficient transmission by Anopheles mosquitoes and the high sensitivity to DEC/albendazole treatment make this species a prime candidate for elimination by mass drug administration (MDA). METHODOLOGY/PRINCIPAL FINDINGS: We evaluated the effect of MDA using DEC and albendazole on B. timori and soil transmitted helminths (STH) in a cross-sectional study of a sentinel village on Alor Island annually over a period of 10 years. Pre-MDA the microfilaria (MF) prevalence was 26% and 80% of the residents had filaria-specific IgG4 antibodies. In 2010, 34 months after the 6(th) round of MDA, MF and antibody rates were only 0.17% and 6.4%, respectively. The MDA campaign had also a beneficial effect on STH. Baseline prevalence rates for Ascaris, hookworm and Trichuris were 34%, 28%, and 11%, respectively; these rates were reduced to 27%, 4%, and 2% one year after the 5(th) round of MDA. Unfortunately, STH rates rebounded 34 months after cessation of MDA and approached pre-MDA rates. However, the intensity of STH infection in 2009 was still reduced, and no heavy infections were detected. CONCLUSIONS/SIGNIFICANCE: MDA with DEC/albendazole has had a major impact on B. timori MF and IgG4 antibody rates, providing a proof of principle that elimination is feasible. We also documented the value of annual DEC/albendazole as a mass de-worming intervention and the importance of continuing some form of STH control after cessation of MDA for filariasis. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/24349595/Impact_of_six_rounds_of_mass_drug_administration_on_Brugian_filariasis_and_soil_transmitted_helminth_infections_in_eastern_Indonesia_ L2 - http://dx.plos.org/10.1371/journal.pntd.0002586 DB - PRIME DP - Unbound Medicine ER -