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Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS.
Gynecol Endocrinol 2014; 30(3):205-8GE

Abstract

Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients. The aim of this work is to compare the effects of myo-inositol and D-chiro-inositol in PCOS. We enrolled 50 patients, with homogeneous bio-physical features, affected by PCOS and menstrual irregularities, and we randomly divided them into two groups: 25 were treated with 4 g of myo-inositol/die plus 400 mcg of folic acid/die orally for six months, 25 with 1 g of D-chiro-inositol/die plus 400 mcg of folic acid/die orally for six months. We analyzed in both groups pre-treatment and post-treatment BMI, systolic and diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, dehydroepiandrosterone sulfate (DHEA-S), Δ-4-androstenedione, SHBG, prolactin, glucose/immunoreactive insulin (IRI) ratio, homeostatic model assessment (HOMA) index, and the resumption of regular menstrual cycles. Both the isoforms of inositol were effective in improving ovarian function and metabolism in patients with PCOS, although myo-inositol showed the most marked effect on the metabolic profile, whereas D-chiro-inositol reduced hyperandrogenism better.

Authors+Show Affiliations

Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina , Messina , Italy and.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24351072

Citation

Pizzo, Alfonsa, et al. "Comparison Between Effects of Myo-inositol and D-chiro-inositol On Ovarian Function and Metabolic Factors in Women With PCOS." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 30, no. 3, 2014, pp. 205-8.
Pizzo A, Laganà AS, Barbaro L. Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS. Gynecol Endocrinol. 2014;30(3):205-8.
Pizzo, A., Laganà, A. S., & Barbaro, L. (2014). Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 30(3), pp. 205-8. doi:10.3109/09513590.2013.860120.
Pizzo A, Laganà AS, Barbaro L. Comparison Between Effects of Myo-inositol and D-chiro-inositol On Ovarian Function and Metabolic Factors in Women With PCOS. Gynecol Endocrinol. 2014;30(3):205-8. PubMed PMID: 24351072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison between effects of myo-inositol and D-chiro-inositol on ovarian function and metabolic factors in women with PCOS. AU - Pizzo,Alfonsa, AU - Laganà,Antonio Simone, AU - Barbaro,Luisa, Y1 - 2013/12/19/ PY - 2013/12/20/entrez PY - 2013/12/20/pubmed PY - 2014/11/11/medline SP - 205 EP - 8 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 30 IS - 3 N2 - Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients. The aim of this work is to compare the effects of myo-inositol and D-chiro-inositol in PCOS. We enrolled 50 patients, with homogeneous bio-physical features, affected by PCOS and menstrual irregularities, and we randomly divided them into two groups: 25 were treated with 4 g of myo-inositol/die plus 400 mcg of folic acid/die orally for six months, 25 with 1 g of D-chiro-inositol/die plus 400 mcg of folic acid/die orally for six months. We analyzed in both groups pre-treatment and post-treatment BMI, systolic and diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, dehydroepiandrosterone sulfate (DHEA-S), Δ-4-androstenedione, SHBG, prolactin, glucose/immunoreactive insulin (IRI) ratio, homeostatic model assessment (HOMA) index, and the resumption of regular menstrual cycles. Both the isoforms of inositol were effective in improving ovarian function and metabolism in patients with PCOS, although myo-inositol showed the most marked effect on the metabolic profile, whereas D-chiro-inositol reduced hyperandrogenism better. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/24351072/Comparison_between_effects_of_myo_inositol_and_D_chiro_inositol_on_ovarian_function_and_metabolic_factors_in_women_with_PCOS_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2013.860120 DB - PRIME DP - Unbound Medicine ER -