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Motor effects of broad beans (Vicia faba) in Parkinson's disease: single dose studies.

Abstract

Broad beans (Vicia faba) are a natural source of L-dopa. To investigate a possible role for this substance in the treatment of Parkinsonian motor oscillations, we carried out single dose studies of Vicia faba pod mixture plus carbidopa in six patients. Motor responses of equivalent magnitude to those of conventional L-dopa medication occurred in five cases with mean onset of 39 min and mean duration of 104 min. Vicia faba meals produced comparable L-dopa blood levels to fasting standard tablet doses and recovery studies yielded 0.25% L-dopa per weight of bean pod mixture. Vicia faba contains sufficient L-dopa to be pharmacologically active in patients with Parkinson's disease and can potentially be incorporated into dietary strategies to manage Parkinsonian motor oscillations.

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  • Authors+Show Affiliations

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    Monash Medical Centre, Melbourne, Australia.

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    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    24352104

    Citation

    Kempster, P A., et al. "Motor Effects of Broad Beans (Vicia Faba) in Parkinson's Disease: Single Dose Studies." Asia Pacific Journal of Clinical Nutrition, vol. 2, no. 2, 1993, pp. 85-9.
    Kempster PA, Bogetic Z, Secombei JW, et al. Motor effects of broad beans (Vicia faba) in Parkinson's disease: single dose studies. Asia Pac J Clin Nutr. 1993;2(2):85-9.
    Kempster, P. A., Bogetic, Z., Secombei, J. W., Martin, H. D., Balazs, N. D., & Wahlqvist, M. L. (1993). Motor effects of broad beans (Vicia faba) in Parkinson's disease: single dose studies. Asia Pacific Journal of Clinical Nutrition, 2(2), pp. 85-9.
    Kempster PA, et al. Motor Effects of Broad Beans (Vicia Faba) in Parkinson's Disease: Single Dose Studies. Asia Pac J Clin Nutr. 1993;2(2):85-9. PubMed PMID: 24352104.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Motor effects of broad beans (Vicia faba) in Parkinson's disease: single dose studies. AU - Kempster,P A, AU - Bogetic,Z, AU - Secombei,J W, AU - Martin,H D, AU - Balazs,N D, AU - Wahlqvist,M L, PY - 2013/12/20/entrez PY - 1993/6/1/pubmed PY - 1993/6/1/medline SP - 85 EP - 9 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 2 IS - 2 N2 - Broad beans (Vicia faba) are a natural source of L-dopa. To investigate a possible role for this substance in the treatment of Parkinsonian motor oscillations, we carried out single dose studies of Vicia faba pod mixture plus carbidopa in six patients. Motor responses of equivalent magnitude to those of conventional L-dopa medication occurred in five cases with mean onset of 39 min and mean duration of 104 min. Vicia faba meals produced comparable L-dopa blood levels to fasting standard tablet doses and recovery studies yielded 0.25% L-dopa per weight of bean pod mixture. Vicia faba contains sufficient L-dopa to be pharmacologically active in patients with Parkinson's disease and can potentially be incorporated into dietary strategies to manage Parkinsonian motor oscillations. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/24352104/Motor_effects_of_broad_beans__Vicia_faba__in_Parkinson's_disease:_single_dose_studies L2 - http://apjcn.nhri.org.tw/server/APJCN/2/2/85.pdf DB - PRIME DP - Unbound Medicine ER -