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[Immunomorphological characteristics of experimental allergic encephalomyelitis induced by an encephalitogenic polypeptide].
Biull Eksp Biol Med. 1987 Mar; 103(3):343-6.BE

Abstract

Encephalitogenic, immunogenic properties of the polypeptide fraction of myelin basic protein (FBP) and CNS lesions have been examined in animals with experimental allergic encephalomyelitis (EAE). FBP was isolated from bovine spinal cord using column chromatography. Administration of 1.0 or 0.1 microgram FBP mixed with complete Freund adjuvant caused neurological and histological EAE manifestations in 76% and 26% of guinea-pigs, respectively. Circulating anti-FBP antibodies were not found in sensitized animals, whereas the incidence and intensity of skin reaction of delayed type hypersensitivity to FBP correlated with the development of EAE and the onset of the disease. Perivascular cell infiltration and demyelination noted in the spinal cord and brain of guinea-pigs were similar to those observed after inoculation of the brain white matter or brain tissue homogenate.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

2435338

Citation

Zhitnukhin, Iu L., and M G. Khizhniak. "[Immunomorphological Characteristics of Experimental Allergic Encephalomyelitis Induced By an Encephalitogenic Polypeptide]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 103, no. 3, 1987, pp. 343-6.
Zhitnukhin IuL, Khizhniak MG. [Immunomorphological characteristics of experimental allergic encephalomyelitis induced by an encephalitogenic polypeptide]. Biull Eksp Biol Med. 1987;103(3):343-6.
Zhitnukhin, I. u. L., & Khizhniak, M. G. (1987). [Immunomorphological characteristics of experimental allergic encephalomyelitis induced by an encephalitogenic polypeptide]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 103(3), 343-6.
Zhitnukhin IuL, Khizhniak MG. [Immunomorphological Characteristics of Experimental Allergic Encephalomyelitis Induced By an Encephalitogenic Polypeptide]. Biull Eksp Biol Med. 1987;103(3):343-6. PubMed PMID: 2435338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunomorphological characteristics of experimental allergic encephalomyelitis induced by an encephalitogenic polypeptide]. AU - Zhitnukhin,Iu L, AU - Khizhniak,M G, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez SP - 343 EP - 6 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 103 IS - 3 N2 - Encephalitogenic, immunogenic properties of the polypeptide fraction of myelin basic protein (FBP) and CNS lesions have been examined in animals with experimental allergic encephalomyelitis (EAE). FBP was isolated from bovine spinal cord using column chromatography. Administration of 1.0 or 0.1 microgram FBP mixed with complete Freund adjuvant caused neurological and histological EAE manifestations in 76% and 26% of guinea-pigs, respectively. Circulating anti-FBP antibodies were not found in sensitized animals, whereas the incidence and intensity of skin reaction of delayed type hypersensitivity to FBP correlated with the development of EAE and the onset of the disease. Perivascular cell infiltration and demyelination noted in the spinal cord and brain of guinea-pigs were similar to those observed after inoculation of the brain white matter or brain tissue homogenate. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/2435338/[Immunomorphological_characteristics_of_experimental_allergic_encephalomyelitis_induced_by_an_encephalitogenic_polypeptide]_ DB - PRIME DP - Unbound Medicine ER -