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Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: A meta-analysis of case-control studies.
Pak J Med Sci 2013; 29(2):693-8PJ

Abstract

OBJECTIVES

Genetic factors and environmental factors play a role in pathogenesis of esophageal squamous cell carcinoma (ESCC). Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting. We conducted a meta-analysis to investigate the association of MTHFR C677T and folate intake with esophageal cancer risk.

METHODOLOGY

MEDLINE, EMBASE and the Chinese Biomedical Database were searched in our study. The quality of studies were evaluated by predefined scale, and The association of polymorphisms of MTHFR C677T and folate intake and ESCC risk was estimated by Odds ratio (ORs) with 95% confidence intervals (CIs).

RESULTS

Nineteen studies (4239 cases and 5575 controls) were included for meta-analysis. A significant association was seen between individuals with MTHFR 677 CT [OR(95%)=1.47(1.32-1.63)] and TT [OR(95%)=1.69(1.49-1.91)] genotypes and ESCC risk (p<0.05). Low intake of folate had significantly higher risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.65(1.1-2.49)], while high intake of folate did not find significant high risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.64 (0.82-3.26)].

CONCLUSIONS

Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T.

Authors+Show Affiliations

Yang Shujuan, West China School of Public Heath, Sichuan University, Chengdu, China.Zhang Jianxing, West China School of Public Heath, Sichuan University, Chengdu, China.Chen Xin-yue, West China School of Public Heath, Sichuan University, Chengdu, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24353609

Citation

Shujuan, Yang, et al. "Methylenetetrahydrofolate Reductase Genetic Polymorphisms and Esophageal Squamous Cell Carcinoma Susceptibility: a Meta-analysis of Case-control Studies." Pakistan Journal of Medical Sciences, vol. 29, no. 2, 2013, pp. 693-8.
Shujuan Y, Jianxing Z, Xin-Yue C. Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: A meta-analysis of case-control studies. Pak J Med Sci. 2013;29(2):693-8.
Shujuan, Y., Jianxing, Z., & Xin-Yue, C. (2013). Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: A meta-analysis of case-control studies. Pakistan Journal of Medical Sciences, 29(2), pp. 693-8.
Shujuan Y, Jianxing Z, Xin-Yue C. Methylenetetrahydrofolate Reductase Genetic Polymorphisms and Esophageal Squamous Cell Carcinoma Susceptibility: a Meta-analysis of Case-control Studies. Pak J Med Sci. 2013;29(2):693-8. PubMed PMID: 24353609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: A meta-analysis of case-control studies. AU - Shujuan,Yang, AU - Jianxing,Zhang, AU - Xin-Yue,Chen, PY - 2012/09/05/received PY - 2012/09/13/revised PY - 2013/01/03/accepted PY - 2013/12/20/entrez PY - 2013/12/20/pubmed PY - 2013/12/20/medline KW - Esophageal cancer KW - Folate intake KW - Meta-analysis KW - Methylenetetrahydrofolate reductase C677T KW - Polymorphism SP - 693 EP - 8 JF - Pakistan journal of medical sciences JO - Pak J Med Sci VL - 29 IS - 2 N2 - OBJECTIVES: Genetic factors and environmental factors play a role in pathogenesis of esophageal squamous cell carcinoma (ESCC). Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting. We conducted a meta-analysis to investigate the association of MTHFR C677T and folate intake with esophageal cancer risk. METHODOLOGY: MEDLINE, EMBASE and the Chinese Biomedical Database were searched in our study. The quality of studies were evaluated by predefined scale, and The association of polymorphisms of MTHFR C677T and folate intake and ESCC risk was estimated by Odds ratio (ORs) with 95% confidence intervals (CIs). RESULTS: Nineteen studies (4239 cases and 5575 controls) were included for meta-analysis. A significant association was seen between individuals with MTHFR 677 CT [OR(95%)=1.47(1.32-1.63)] and TT [OR(95%)=1.69(1.49-1.91)] genotypes and ESCC risk (p<0.05). Low intake of folate had significantly higher risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.65(1.1-2.49)], while high intake of folate did not find significant high risk of esophageal cancer among individuals with CT/TT genotype [OR(95%)=1.64 (0.82-3.26)]. CONCLUSIONS: Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T. SN - 1682-024X UR - https://www.unboundmedicine.com/medline/citation/24353609/Methylenetetrahydrofolate_reductase_genetic_polymorphisms_and_esophageal_squamous_cell_carcinoma_susceptibility:_A_meta_analysis_of_case_control_studies_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24353609/ DB - PRIME DP - Unbound Medicine ER -