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Vitamin D levels and bone metabolism in Chinese adult patients with inflammatory bowel disease.
J Dig Dis 2014; 15(3):116-23JD

Abstract

OBJECTIVE

We aimed to investigate the serum 25-hydroxyvitamin D3 (25[OH]D3) levels and bone metabolism in adult Chinese patients with inflammatory bowel disease (IBD) and to evaluate the correlation between vitamin D levels and the disease activity as well as the potential risk factors.

METHODS

Age- and gender-matched cohort of IBD patients (124 with ulcerative colitis [UC] and 107 with Crohn's disease [CD]) and 122 healthy controls were enrolled in this study. Serum levels of 25(OH)D3 and bone mineral density (BMD) were measured, and the correlation between the two parameters and the severity of the disease as well as the clinical risk factors were analyzed.

RESULTS

Serum 25(OH)D3 levels were lower in UC (10.32 ± 4.46 ng/mL, P < 0.001) and CD patients (11.57 ± 5.02 ng/mL, P = 0.029) than that in healthy controls (12.87 ± 4.40 ng/mL). 25(OH)D3 levels were negatively correlated with the disease severity of both UC (r = -0.371, P < 0.001) and CD (r = -0.285, P = 0.030). The incidences of osteopenia and osteoporosis were high in the IBD patients (37.9% and 3.2% in UC and 30.8% and 4.7% in CD, respectively). Cumulative quantity of glucocorticoids use was significantly associated with osteopenia and osteoporosis in both UC (odds ratio [OR] 1.219, 95% confidence interval [CI] 1.054-1.410, P = 0.008) and CD patients (OR 1.288, 95% CI 1.033-1.606, P = 0.025).

CONCLUSIONS

Vitamin D deficiency is likely to occur in Chinese patients with IBD and is closely associated with the severity of the disease. Glucocorticoids accumulation is a risk factor for osteopenia and osteoporosis.

Authors+Show Affiliations

Department of Gastroenterology, Key Laboratory of Chinese Health Ministry, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24354597

Citation

Tan, Bei, et al. "Vitamin D Levels and Bone Metabolism in Chinese Adult Patients With Inflammatory Bowel Disease." Journal of Digestive Diseases, vol. 15, no. 3, 2014, pp. 116-23.
Tan B, Li P, Lv H, et al. Vitamin D levels and bone metabolism in Chinese adult patients with inflammatory bowel disease. J Dig Dis. 2014;15(3):116-23.
Tan, B., Li, P., Lv, H., Li, Y., Wang, O., Xing, X. P., & Qian, J. M. (2014). Vitamin D levels and bone metabolism in Chinese adult patients with inflammatory bowel disease. Journal of Digestive Diseases, 15(3), pp. 116-23. doi:10.1111/1751-2980.12118.
Tan B, et al. Vitamin D Levels and Bone Metabolism in Chinese Adult Patients With Inflammatory Bowel Disease. J Dig Dis. 2014;15(3):116-23. PubMed PMID: 24354597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D levels and bone metabolism in Chinese adult patients with inflammatory bowel disease. AU - Tan,Bei, AU - Li,Pan, AU - Lv,Hong, AU - Li,Yue, AU - Wang,Ou, AU - Xing,Xiao Ping, AU - Qian,Jia Ming, PY - 2013/12/21/entrez PY - 2013/12/21/pubmed PY - 2014/10/21/medline KW - Crohn's disease KW - bone mineral density KW - inflammatory bowel disease KW - ulcerative colitis KW - vitamin D SP - 116 EP - 23 JF - Journal of digestive diseases JO - J Dig Dis VL - 15 IS - 3 N2 - OBJECTIVE: We aimed to investigate the serum 25-hydroxyvitamin D3 (25[OH]D3) levels and bone metabolism in adult Chinese patients with inflammatory bowel disease (IBD) and to evaluate the correlation between vitamin D levels and the disease activity as well as the potential risk factors. METHODS: Age- and gender-matched cohort of IBD patients (124 with ulcerative colitis [UC] and 107 with Crohn's disease [CD]) and 122 healthy controls were enrolled in this study. Serum levels of 25(OH)D3 and bone mineral density (BMD) were measured, and the correlation between the two parameters and the severity of the disease as well as the clinical risk factors were analyzed. RESULTS: Serum 25(OH)D3 levels were lower in UC (10.32 ± 4.46 ng/mL, P < 0.001) and CD patients (11.57 ± 5.02 ng/mL, P = 0.029) than that in healthy controls (12.87 ± 4.40 ng/mL). 25(OH)D3 levels were negatively correlated with the disease severity of both UC (r = -0.371, P < 0.001) and CD (r = -0.285, P = 0.030). The incidences of osteopenia and osteoporosis were high in the IBD patients (37.9% and 3.2% in UC and 30.8% and 4.7% in CD, respectively). Cumulative quantity of glucocorticoids use was significantly associated with osteopenia and osteoporosis in both UC (odds ratio [OR] 1.219, 95% confidence interval [CI] 1.054-1.410, P = 0.008) and CD patients (OR 1.288, 95% CI 1.033-1.606, P = 0.025). CONCLUSIONS: Vitamin D deficiency is likely to occur in Chinese patients with IBD and is closely associated with the severity of the disease. Glucocorticoids accumulation is a risk factor for osteopenia and osteoporosis. SN - 1751-2980 UR - https://www.unboundmedicine.com/medline/citation/24354597/Vitamin_D_levels_and_bone_metabolism_in_Chinese_adult_patients_with_inflammatory_bowel_disease_ L2 - https://doi.org/10.1111/1751-2980.12118 DB - PRIME DP - Unbound Medicine ER -