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Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium.
Pharm Dev Technol. 2015 Jun; 20(4):507-12.PD

Abstract

The preparation of lipophilic matrix tablets for the sustained release of water soluble drugs via direct compression is not always feasible due to poor flow and rapid drug release. The aim was to evaluate the potential for developing sustained-release diclofenac sodium tablets, using Compritol® 888 ATO as a lipid matrix, by a wet granulation technique. The effects of wet granulation method (planetary mixer and fluid-bed) and liquid binder type (HPMC Metolose® 603, 606 or 615) on weight uniformity, tensile strength and release rates were investigated. The influence of compression force and speed during tablet manufacture under simulated rotary press production conditions were also evaluated. Rapid release of diclofenac sodium from directly compressed matrices was observed. A wet granulation technique using different HPMC binders produced free-flowing granules and matrices which released diclofenac sodium in a sustained manner over several hours. When the formulation comprising the lowest viscosity grade HPMC (Metolose® 603) was further evaluated using a laboratory scale fluid-bed system, consistently sized granules with good flowability and matrices with good weight uniformity and tensile strengths were produced. Release rates were consistent over a range of compression speeds and forces indicating the suitability of the formulation for production on a rotary tablet press.

Authors+Show Affiliations

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University , Liverpool , UK .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24354893

Citation

Roberts, Matthew, et al. "Preparation and Characterization of Compritol 888 ATO Matrix Tablets for the Sustained Release of Diclofenac Sodium." Pharmaceutical Development and Technology, vol. 20, no. 4, 2015, pp. 507-12.
Roberts M, Pulcini L, Mostafa S, et al. Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium. Pharm Dev Technol. 2015;20(4):507-12.
Roberts, M., Pulcini, L., Mostafa, S., Cuppok-Rosiaux, Y., & Marchaud, D. (2015). Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium. Pharmaceutical Development and Technology, 20(4), 507-12. https://doi.org/10.3109/10837450.2013.871035
Roberts M, et al. Preparation and Characterization of Compritol 888 ATO Matrix Tablets for the Sustained Release of Diclofenac Sodium. Pharm Dev Technol. 2015;20(4):507-12. PubMed PMID: 24354893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium. AU - Roberts,Matthew, AU - Pulcini,Lia, AU - Mostafa,Shabbir, AU - Cuppok-Rosiaux,Yvonne, AU - Marchaud,Delphine, Y1 - 2013/12/20/ PY - 2013/12/21/entrez PY - 2013/12/21/pubmed PY - 2016/2/5/medline KW - Fluid bed KW - glyceryl behenate KW - lipophilic matrix KW - rotary press simulator KW - wet granulation SP - 507 EP - 12 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 20 IS - 4 N2 - The preparation of lipophilic matrix tablets for the sustained release of water soluble drugs via direct compression is not always feasible due to poor flow and rapid drug release. The aim was to evaluate the potential for developing sustained-release diclofenac sodium tablets, using Compritol® 888 ATO as a lipid matrix, by a wet granulation technique. The effects of wet granulation method (planetary mixer and fluid-bed) and liquid binder type (HPMC Metolose® 603, 606 or 615) on weight uniformity, tensile strength and release rates were investigated. The influence of compression force and speed during tablet manufacture under simulated rotary press production conditions were also evaluated. Rapid release of diclofenac sodium from directly compressed matrices was observed. A wet granulation technique using different HPMC binders produced free-flowing granules and matrices which released diclofenac sodium in a sustained manner over several hours. When the formulation comprising the lowest viscosity grade HPMC (Metolose® 603) was further evaluated using a laboratory scale fluid-bed system, consistently sized granules with good flowability and matrices with good weight uniformity and tensile strengths were produced. Release rates were consistent over a range of compression speeds and forces indicating the suitability of the formulation for production on a rotary tablet press. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/24354893/Preparation_and_characterization_of_Compritol_888_ATO_matrix_tablets_for_the_sustained_release_of_diclofenac_sodium_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2013.871035 DB - PRIME DP - Unbound Medicine ER -